Regorafenib_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Regorafenib perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Regorafenib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.203036
TRIO trio Rho guanine nucleotide exchange factor 0.128606
NDRG1 N-myc downstream regulated 1 0.106439
UBC ubiquitin C 0.0875545
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0734288
COL5A1 collagen, type V, alpha 1 0.0639382
IGFBP3 insulin-like growth factor binding protein 3 0.0624555
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0620093
FLNB filamin B, beta 0.0560421
DLG1 discs, large homolog 1 (Drosophila) 0.0526008
SEPTIN9 septin 9 0.0468647
ANKRD11 ankyrin repeat domain 11 0.0442444
SHB Src homology 2 domain containing adaptor protein B 0.042853
SLC22A23 solute carrier family 22, member 23 0.0420177
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0406332
NFE2L1 nuclear factor, erythroid 2-like 1 0.0402489
SP3 Sp3 transcription factor 0.0363684
PKM pyruvate kinase, muscle 0.0362859
NAV1 neuron navigator 1 0.0349704
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0338211
BHLHE40 basic helix-loop-helix family, member e40 0.0329782
B2M beta-2-microglobulin 0.0327687
SRRM2 serine/arginine repetitive matrix 2 0.0313893
VEGFA vascular endothelial growth factor A 0.0307558
ENO1 enolase 1, (alpha) 0.0302704
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0297458
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0294853
RPS8 ribosomal protein S8 0.0292126
LAMB1 laminin, beta 1 0.028785
SLC39A11 solute carrier family 39, member 11 0.0284249
SYTL3 synaptotagmin-like 3 0.028156
ERRFI1 ERBB receptor feedback inhibitor 1 0.0270347
MYH9 myosin, heavy chain 9, non-muscle 0.0269445
SAMD4A sterile alpha motif domain containing 4A 0.0267448
SPNS2 spinster homolog 2 (Drosophila) 0.0266516
H2AC6 H2A clustered histone 6 0.0261297
EFNA5 ephrin-A5 0.0254554
MT2A metallothionein 2A 0.025033
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0248074
PDGFB platelet-derived growth factor beta polypeptide 0.0245545
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0242884
RPL28 ribosomal protein L28 0.0241729
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0236517
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0232672
RPS12 ribosomal protein S12 0.0229989
MPRIP myosin phosphatase Rho interacting protein 0.0228852
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0226024
RNF24 ring finger protein 24 0.0220788
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0216555
YEATS2 YEATS domain containing 2 0.0213544
TPM3 tropomyosin 3 0.0213211
MED15 mediator complex subunit 15 0.0213117
PODXL podocalyxin-like 0.0210519
TGFB1 transforming growth factor, beta 1 0.0207777
NCOR2 nuclear receptor corepressor 2 0.0207371
MSN moesin 0.0203275
ZBTB7C zinc finger and BTB domain containing 7C 0.0201444
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.0198638
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.0195011
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.019457
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0190656
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.019041
SDC4 syndecan 4 0.0189896
RPS3 ribosomal protein S3 0.01885
FTH1 ferritin, heavy polypeptide 1 0.0187747
STEAP3 STEAP family member 3, metalloreductase 0.018641
SEC61G Sec61 gamma subunit 0.0184295
SET SET nuclear proto-oncogene 0.0182713
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0182147
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0181997
FOSL1 FOS-like antigen 1 0.0181548
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0179722
PCDH10 protocadherin 10 0.0178467
AXL AXL receptor tyrosine kinase 0.0176767
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0174549
RPS27A ribosomal protein S27a 0.0174188
EZR ezrin 0.0173709
HILPDA hypoxia inducible lipid droplet-associated 0.0171623
FAM114A1 family with sequence similarity 114, member A1 0.0170156
PGM3 phosphoglucomutase 3 0.0169172
RPS2 ribosomal protein S2 0.016899
NACA nascent polypeptide-associated complex alpha subunit 0.0167993
CD109 CD109 molecule 0.0167117
RPS17 ribosomal protein S17 0.0165517
FOSL2 FOS-like antigen 2 0.0164456
CALR calreticulin 0.0163576
RRM2 ribonucleotide reductase M2 0.0163189
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0163124
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0162715
OPTN optineurin 0.0161907
TNNT1 troponin T type 1 (skeletal, slow) 0.0158797
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0156661
LATS2 large tumor suppressor kinase 2 0.0155728
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 0.0154837
ZFP36 ZFP36 ring finger protein 0.0153757
ZMIZ1 zinc finger, MIZ-type containing 1 0.01535
TPM1 tropomyosin 1 (alpha) 0.0153002
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 0.0152432
ANKRD33B ankyrin repeat domain 33B 0.0151913
PFKP phosphofructokinase, platelet 0.0151858

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.22861
VIM vimentin -0.148231
TMSB10 thymosin beta 10 -0.141411
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.13726
FBN1 fibrillin 1 -0.137142
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.135863
LOX lysyl oxidase -0.106131
SOD2 superoxide dismutase 2, mitochondrial -0.0850515
ZBTB20 zinc finger and BTB domain containing 20 -0.0837777
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.08029
CCND1 cyclin D1 -0.0794238
COL8A1 collagen, type VIII, alpha 1 -0.0707416
MEIS2 Meis homeobox 2 -0.0691589
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0656865
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0614639
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0569771
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0546648
TMSB4X thymosin beta 4, X-linked -0.0530329
FNDC3A fibronectin type III domain containing 3A -0.0514365
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0512221
COL5A2 collagen, type V, alpha 2 -0.0510083
TPT1 tumor protein, translationally-controlled 1 -0.0509999
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0486497
CANX calnexin -0.0484584
FRMD5 FERM domain containing 5 -0.0484021
RTN4 reticulon 4 -0.0483912
AHNAK AHNAK nucleoprotein -0.0477342
HLA-B major histocompatibility complex, class I, B -0.0475449
GARS1 glycyl-tRNA synthetase 1 -0.0467528
PTMA prothymosin, alpha -0.0458803
BIRC6 baculoviral IAP repeat containing 6 -0.0443898
DST dystonin -0.0437275
ZNFX1 zinc finger, NFX1-type containing 1 -0.0433787
SLC38A1 solute carrier family 38, member 1 -0.0431299
IFI16 interferon, gamma-inducible protein 16 -0.0429293
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.04268
JAZF1 JAZF zinc finger 1 -0.0426622
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0424974
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0416235
SRPK2 SRSF protein kinase 2 -0.0408889
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0401786
ANKRD10 ankyrin repeat domain 10 -0.0398251
ZEB1 zinc finger E-box binding homeobox 1 -0.0388714
HDLBP high density lipoprotein binding protein -0.0387956
AUTS2 autism susceptibility candidate 2 -0.0387866
NAV2 neuron navigator 2 -0.0380438
COL3A1 collagen, type III, alpha 1 -0.0380422
CDH13 cadherin 13 -0.0374536
AFF4 AF4/FMR2 family, member 4 -0.0374256
APP amyloid beta (A4) precursor protein -0.0371718
VCL vinculin -0.036707
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0356172
NT5C2 5'-nucleotidase, cytosolic II -0.0355043
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0352342
ARF1 ADP-ribosylation factor 1 -0.0347496
FBXL7 F-box and leucine-rich repeat protein 7 -0.0343205
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0339764
TUBB tubulin, beta class I -0.0339115
PGK1 phosphoglycerate kinase 1 -0.033833
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.033488
DPYSL2 dihydropyrimidinase-like 2 -0.0334065
NIPBL Nipped-B homolog (Drosophila) -0.0332943
USP34 ubiquitin specific peptidase 34 -0.0328417
HLA-E major histocompatibility complex, class I, E -0.0327999
WARS1 tryptophanyl-tRNA synthetase 1 -0.0326963
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0326598
TM4SF1 transmembrane 4 L six family member 1 -0.032333
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0320611
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0320148
CAVIN1 caveolae associated protein 1 -0.0318436
NUMB numb homolog (Drosophila) -0.0317916
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0317672
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0313019
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0311109
SAMD9 sterile alpha motif domain containing 9 -0.0311046
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0308345
THBS2 thrombospondin 2 -0.0308114
KMT2C lysine (K)-specific methyltransferase 2C -0.0307532
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0307083
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0306898
PRRC2C proline-rich coiled-coil 2C -0.0302978
SLC38A2 solute carrier family 38, member 2 -0.0300908
S100A6 S100 calcium binding protein A6 -0.0295153
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0294861
SH3KBP1 SH3-domain kinase binding protein 1 -0.0294607
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0289714
SPAG9 sperm associated antigen 9 -0.0289405
IFIH1 interferon induced with helicase C domain 1 -0.0286545
SCARB2 scavenger receptor class B, member 2 -0.02815
MYL12B myosin, light chain 12B, regulatory -0.0280467
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0279932
SBF2 SET binding factor 2 -0.0279619
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0279523
MRPS6 mitochondrial ribosomal protein S6 -0.027946
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0278872
CSNK1A1 casein kinase 1, alpha 1 -0.027776
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0276376
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0276275
MAP1B microtubule-associated protein 1B -0.0276007
RPL35A ribosomal protein L35a -0.0273544