Regorafenib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Regorafenib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Regorafenib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MMP12 matrix metallopeptidase 12 0.120359
DST dystonin 0.100301
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0889618
CELF2 CUGBP, Elav-like family member 2 0.0825891
DPYD dihydropyrimidine dehydrogenase 0.0734328
AREG amphiregulin 0.0690569
BIRC3 baculoviral IAP repeat containing 3 0.0659416
SPATS2 spermatogenesis associated, serine-rich 2 0.0646733
CCN2 cellular communication network factor 2 0.0576887
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.056266
ATP11A ATPase, class VI, type 11A 0.0562638
MARCHF4 membrane associated ring-CH-type finger 4 0.0562162
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0551227
ZBTB20 zinc finger and BTB domain containing 20 0.0541565
NRXN3 neurexin 3 0.0532579
ANXA1 annexin A1 0.0532319
PCDH7 protocadherin 7 0.0526059
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0514429
NLGN1 neuroligin 1 0.0503349
RABGAP1L RAB GTPase activating protein 1-like 0.048276
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0481979
MGAT4C MGAT4 family, member C 0.047667
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0466817
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0458204
NEBL nebulette 0.0451761
TENM3 teneurin transmembrane protein 3 0.0451062
CCSER1 coiled-coil serine-rich protein 1 0.0440699
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0435086
SFPQ splicing factor proline/glutamine-rich 0.0434294
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0431499
NECTIN3 nectin cell adhesion molecule 3 0.0426788
USP34 ubiquitin specific peptidase 34 0.0421866
BIRC2 baculoviral IAP repeat containing 2 0.0419329
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0417921
YEATS2 YEATS domain containing 2 0.0392717
YAP1 Yes-associated protein 1 0.0388696
PDGFC platelet derived growth factor C 0.038173
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0374063
SBF2 SET binding factor 2 0.037232
POTEF POTE ankyrin domain family, member F 0.0353898
TMEM41B transmembrane protein 41B 0.0351666
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.034861
SRRM2 serine/arginine repetitive matrix 2 0.0343609
RPL21 ribosomal protein L21 0.0340188
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0338644
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0330099
NHSL1 NHS-like 1 0.0328354
AXIN2 axin 2 0.0327685
NCOR2 nuclear receptor corepressor 2 0.0322696
NCOA6 nuclear receptor coactivator 6 0.0318967
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0314044
RPS23 ribosomal protein S23 0.0305317
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0303978
RPL4 ribosomal protein L4 0.0297788
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0297351
KLC1 kinesin light chain 1 0.0294386
ANKRD36 ankyrin repeat domain 36 0.0293198
EPHA6 EPH receptor A6 0.0289095
SON SON DNA binding protein 0.0286723
CASC3 cancer susceptibility candidate 3 0.0286134
FER fer (fps/fes related) tyrosine kinase 0.0285513
GABARAPL1 GABA(A) receptor-associated protein like 1 0.0280382
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0274888
TUBA1B tubulin, alpha 1b 0.0272576
RPS29 ribosomal protein S29 0.0269422
EXOC4 exocyst complex component 4 0.0269049
RPL3 ribosomal protein L3 0.0263948
BRD2 bromodomain containing 2 0.0257884
ARF3 ADP-ribosylation factor 3 0.0257208
ZFYVE16 zinc finger, FYVE domain containing 16 0.0255899
ZNF519 zinc finger protein 519 0.0255475
XRN1 5'-3' exoribonuclease 1 0.0255034
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0253884
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0253792
MKI67 marker of proliferation Ki-67 0.0253707
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0249384
GSE1 Gse1 coiled-coil protein 0.0247224
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0244894
CCNL1 cyclin L1 0.0244435
PRRC2A proline-rich coiled-coil 2A 0.0244339
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0244314
ANKRD12 ankyrin repeat domain 12 0.0243292
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0239971
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0239439
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 0.0238049
ZSWIM6 zinc finger, SWIM-type containing 6 0.023292
LRP6 low density lipoprotein receptor-related protein 6 0.0231001
ZNF292 zinc finger protein 292 0.0226625
TCERG1 transcription elongation regulator 1 0.0225945
NUP98 nucleoporin 98kDa 0.0225647
KMT2D lysine (K)-specific methyltransferase 2D 0.0225036
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0223596
AAK1 AP2 associated kinase 1 0.0221901
CBX5 chromobox homolog 5 0.0221272
SMYD3 SET and MYND domain containing 3 0.021791
PATJ PATJ crumbs cell polarity complex component 0.0217249
SRPK2 SRSF protein kinase 2 0.0217198
PHF21A PHD finger protein 21A 0.021568
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0214178
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0213441

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.109042
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.100724
TMSB10 thymosin beta 10 -0.0908557
PCBP2 poly(rC) binding protein 2 -0.0795415
JMJD1C jumonji domain containing 1C -0.0723175
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0625489
HSPB1 heat shock 27kDa protein 1 -0.0620132
RPL35A ribosomal protein L35a -0.0614003
CANX calnexin -0.0594914
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0555551
MYL12B myosin, light chain 12B, regulatory -0.0553551
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0551964
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0503092
IFIH1 interferon induced with helicase C domain 1 -0.049546
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0490233
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0482951
RAD21 RAD21 homolog (S. pombe) -0.0477204
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.047003
HMGA1 high mobility group AT-hook 1 -0.0469839
FBXO11 F-box protein 11 -0.0459376
VIM vimentin -0.0458852
CLTC clathrin, heavy chain (Hc) -0.0457612
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0454249
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0446482
PDE4D phosphodiesterase 4D, cAMP-specific -0.0436776
STAG2 stromal antigen 2 -0.0432121
INTS6 integrator complex subunit 6 -0.0427591
NAP1L1 nucleosome assembly protein 1-like 1 -0.0425817
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0423884
PCNP PEST proteolytic signal containing nuclear protein -0.0421211
S100A6 S100 calcium binding protein A6 -0.0418005
SLC38A1 solute carrier family 38, member 1 -0.0407997
FTL ferritin, light polypeptide -0.0396984
RPL12 ribosomal protein L12 -0.039324
MORF4L2 mortality factor 4 like 2 -0.0392219
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0391621
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0383246
CCDC47 coiled-coil domain containing 47 -0.036805
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0363685
HMGB2 high mobility group box 2 -0.0363145
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0361978
HMGB1 high mobility group box 1 -0.0358142
AHNAK AHNAK nucleoprotein -0.035637
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0349567
SMC4 structural maintenance of chromosomes 4 -0.0348202
GARS1 glycyl-tRNA synthetase 1 -0.0347126
NIPBL Nipped-B homolog (Drosophila) -0.0346324
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0344296
RLF rearranged L-myc fusion -0.0339233
ADGRG6 adhesion G protein-coupled receptor G6 -0.0324009
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0319101
CXADR coxsackie virus and adenovirus receptor -0.0312954
SPAG9 sperm associated antigen 9 -0.030975
ZNF217 zinc finger protein 217 -0.0308949
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0306606
CALR calreticulin -0.0304995
LOC112694756 uncharaterized LOC112694756 -0.0302538
S100A10 S100 calcium binding protein A10 -0.0296209
SPTSSA serine palmitoyltransferase, small subunit A -0.0292601
VDAC1 voltage-dependent anion channel 1 -0.0291979
RPS24 ribosomal protein S24 -0.0291555
RPL34 ribosomal protein L34 -0.0291159
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0282396
RPLP0 ribosomal protein, large, P0 -0.0282306
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0280506
NPEPPS aminopeptidase puromycin sensitive -0.0279156
EEF2 eukaryotic translation elongation factor 2 -0.0277473
YBX3 Y box binding protein 3 -0.0274531
USP15 ubiquitin specific peptidase 15 -0.0274516
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0270763
RTN3 reticulon 3 -0.0269144
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0268724
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0266802
PCDH9 protocadherin 9 -0.0266175
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0265504
CPNE1 copine I -0.0264675
HBP1 HMG-box transcription factor 1 -0.0261311
ADIPOR2 adiponectin receptor 2 -0.0257963
ECT2 epithelial cell transforming 2 -0.0256916
HSPA8 heat shock 70kDa protein 8 -0.0256688
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0256036
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0254451
CDK12 cyclin-dependent kinase 12 -0.0252386
GJA1 gap junction protein, alpha 1, 43kDa -0.025145
DNAH14 dynein, axonemal, heavy chain 14 -0.0251165
TPI1 triosephosphate isomerase 1 -0.0250558
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0249015
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0243917
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme -0.0243849
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0242324
WTAP Wilms tumor 1 associated protein -0.0242075
ARF1 ADP-ribosylation factor 1 -0.0240537
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0239587
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0238215
NAMPT nicotinamide phosphoribosyltransferase -0.0232564
TM9SF3 transmembrane 9 superfamily member 3 -0.0231974
OAZ1 ornithine decarboxylase antizyme 1 -0.0231188
NSD2 nuclear receptor binding SET domain protein 2 -0.0230253
TUBB tubulin, beta class I -0.0228816
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0228562