| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Regorafenib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Regorafenib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.16293 |
| VEGFA | vascular endothelial growth factor A | 0.106681 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0974211 |
| FN1 | fibronectin 1 | 0.0902375 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0886881 |
| PTK2 | protein tyrosine kinase 2 | 0.0823796 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0779736 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0655287 |
| ATP13A3 | ATPase type 13A3 | 0.0640373 |
| CD44 | CD44 molecule (Indian blood group) | 0.0530257 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0487622 |
| CDH13 | cadherin 13 | 0.0479516 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0467118 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0460632 |
| LDHA | lactate dehydrogenase A | 0.0447235 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0445787 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0444237 |
| EFNA5 | ephrin-A5 | 0.0412575 |
| FNDC3B | fibronectin type III domain containing 3B | 0.039999 |
| COL5A1 | collagen, type V, alpha 1 | 0.0396433 |
| RASA2 | RAS p21 protein activator 2 | 0.038589 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0381068 |
| PDE10A | phosphodiesterase 10A | 0.0380078 |
| VMP1 | vacuole membrane protein 1 | 0.0375125 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0361346 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0358462 |
| GOLGA4 | golgin A4 | 0.0358137 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0346343 |
| MRTFA | myocardin related transcription factor A | 0.0345712 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0344187 |
| TFG | TRK-fused gene | 0.0343844 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0343087 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0329045 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0317643 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0310226 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0310211 |
| TMEM39A | transmembrane protein 39A | 0.0302595 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.030168 |
| RPL3 | ribosomal protein L3 | 0.0300541 |
| COL1A2 | collagen, type I, alpha 2 | 0.0299925 |
| ANXA1 | annexin A1 | 0.0297328 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0292312 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0291664 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0290888 |
| COPA | coatomer protein complex, subunit alpha | 0.0285476 |
| RPS3 | ribosomal protein S3 | 0.028484 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0284112 |
| FMNL2 | formin-like 2 | 0.0283067 |
| TPM4 | tropomyosin 4 | 0.0279865 |
| COL3A1 | collagen, type III, alpha 1 | 0.0271961 |
| MTSS1 | metastasis suppressor 1 | 0.0270801 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0269391 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0268348 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0268329 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0268144 |
| TMF1 | TATA element modulatory factor 1 | 0.0267833 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0267353 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0261177 |
| CD47 | CD47 molecule | 0.0260329 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0259201 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0253355 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0246691 |
| MED13L | mediator complex subunit 13-like | 0.0246346 |
| AGO3 | argonaute RISC catalytic component 3 | 0.024483 |
| NOTCH2 | notch 2 | 0.0243876 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0242157 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0241728 |
| SDC4 | syndecan 4 | 0.0238949 |
| TNS1 | tensin 1 | 0.0238844 |
| CLINT1 | clathrin interactor 1 | 0.0238387 |
| RPL26 | ribosomal protein L26 | 0.0238137 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0235991 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0234079 |
| CASC3 | cancer susceptibility candidate 3 | 0.023331 |
| MATR3 | matrin 3 | 0.0229711 |
| SQLE | squalene epoxidase | 0.0229218 |
| NBAS | neuroblastoma amplified sequence | 0.0227726 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0223711 |
| MSN | moesin | 0.022369 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0223618 |
| RPS25 | ribosomal protein S25 | 0.0222315 |
| RPL11 | ribosomal protein L11 | 0.0221955 |
| FTO | fat mass and obesity associated | 0.0221843 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0219857 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0219625 |
| LOXL2 | lysyl oxidase-like 2 | 0.0219317 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0218648 |
| ARRDC3 | arrestin domain containing 3 | 0.0218456 |
| FLNB | filamin B, beta | 0.0216993 |
| FAM219A | family with sequence similarity 219, member A | 0.0216037 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0215252 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0215119 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0212825 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0209275 |
| STT3A | STT3A, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0208676 |
| NUP58 | nucleoporin 58 | 0.0208468 |
| CTSB | cathepsin B | 0.0206804 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0206322 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0206216 |
| FOSL1 | FOS-like antigen 1 | 0.0203603 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.348192 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.193859 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.14949 |
| IER3 | immediate early response 3 | -0.101349 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0888265 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0849824 |
| CANX | calnexin | -0.075792 |
| AHNAK | AHNAK nucleoprotein | -0.0693933 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0600975 |
| TMSB10 | thymosin beta 10 | -0.0579376 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0520233 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0520209 |
| ACTG1 | actin gamma 1 | -0.0477439 |
| VCL | vinculin | -0.0468109 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0453469 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0434281 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0413689 |
| TMSB4X | thymosin beta 4, X-linked | -0.0409601 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0406266 |
| ENO1 | enolase 1, (alpha) | -0.0406171 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0403547 |
| HDAC9 | histone deacetylase 9 | -0.0403448 |
| CALD1 | caldesmon 1 | -0.0387154 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.038517 |
| VIM | vimentin | -0.0382445 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0379013 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0376693 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0365498 |
| MAP1B | microtubule-associated protein 1B | -0.0361077 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0359986 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0356502 |
| FBN1 | fibrillin 1 | -0.0353603 |
| PALLD | palladin, cytoskeletal associated protein | -0.0340009 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0334459 |
| LOX | lysyl oxidase | -0.0330838 |
| PGK1 | phosphoglycerate kinase 1 | -0.0330561 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0330254 |
| SDC2 | syndecan 2 | -0.0323071 |
| AHR | aryl hydrocarbon receptor | -0.031686 |
| COL1A1 | collagen, type I, alpha 1 | -0.0312108 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0311885 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0309913 |
| H1-0 | H1.0 linker histone | -0.030961 |
| SQSTM1 | sequestosome 1 | -0.0303444 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0300379 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0299557 |
| NABP1 | nucleic acid binding protein 1 | -0.0295582 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0293357 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0292806 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0291483 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0291176 |
| DST | dystonin | -0.0289694 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0289664 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0284445 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0284098 |
| HMGA1 | high mobility group AT-hook 1 | -0.0280485 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0277462 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0274239 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.027174 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0269857 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0267705 |
| PXDN | peroxidasin | -0.0262776 |
| FTL | ferritin, light polypeptide | -0.0255114 |
| CAVIN1 | caveolae associated protein 1 | -0.0251827 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0251655 |
| FOXP1 | forkhead box P1 | -0.0251221 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0249832 |
| FRMD4A | FERM domain containing 4A | -0.0249759 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0248463 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.023448 |
| STC1 | stanniocalcin 1 | -0.0232098 |
| HLA-B | major histocompatibility complex, class I, B | -0.023139 |
| NREP | neuronal regeneration related protein | -0.0229896 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0229332 |
| PRELID2 | PRELI domain containing 2 | -0.0225931 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0224143 |
| MORF4L2 | mortality factor 4 like 2 | -0.0220514 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0220513 |
| PRSS23 | protease, serine, 23 | -0.0216438 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0214978 |
| JAK1 | Janus kinase 1 | -0.0210964 |
| TUBB | tubulin, beta class I | -0.0205722 |
| BCAP29 | B-cell receptor-associated protein 29 | -0.0204294 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.020213 |
| RRBP1 | ribosome binding protein 1 | -0.0200262 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0200225 |
| SEPTIN7 | septin 7 | -0.0199574 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0198591 |
| FBXO32 | F-box protein 32 | -0.019839 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0197718 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0197575 |
| TMED7 | transmembrane emp24 protein transport domain containing 7 | -0.019753 |
| CD82 | CD82 molecule | -0.0195963 |
| HDLBP | high density lipoprotein binding protein | -0.0195127 |
| IL6ST | interleukin 6 signal transducer | -0.0194374 |
| CMIP | c-Maf inducing protein | -0.0193402 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0191887 |
| TBX3 | T-box 3 | -0.0189273 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.018843 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0187833 |
