| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Regorafenib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Regorafenib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.180436 |
| SDC4 | syndecan 4 | 0.136041 |
| FNDC3B | fibronectin type III domain containing 3B | 0.102907 |
| FN1 | fibronectin 1 | 0.095907 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0923856 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0909806 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0908728 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0908197 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0900393 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0856807 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0765324 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0753448 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0752274 |
| PDGFB | platelet-derived growth factor beta polypeptide | 0.0709543 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0694434 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0684507 |
| TNS1 | tensin 1 | 0.0670198 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.063023 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0621042 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0612551 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0562887 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0558006 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0556582 |
| ENO1 | enolase 1, (alpha) | 0.0550966 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.051226 |
| APOA2 | apolipoprotein A-II | 0.0504501 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0496716 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0470217 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.0466397 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0453208 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.044329 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0429937 |
| VEGFA | vascular endothelial growth factor A | 0.0428371 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0421255 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.04149 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0403774 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0384409 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0379519 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0375473 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.036526 |
| STK17A | serine/threonine kinase 17a | 0.0364522 |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.0355532 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0354783 |
| HLF | hepatic leukemia factor | 0.0354025 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0342996 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0341467 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0337774 |
| PEG3 | paternally expressed 3 | 0.0336173 |
| LDHA | lactate dehydrogenase A | 0.0335756 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0332466 |
| CFB | complement factor B | 0.0322281 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0317721 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0317496 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0315967 |
| OGA | O-GlcNAcase | 0.0300899 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0297464 |
| H1-0 | H1.0 linker histone | 0.0293499 |
| OSMR | oncostatin M receptor | 0.0292207 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.029173 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0290589 |
| RPL4 | ribosomal protein L4 | 0.0285037 |
| PHF21A | PHD finger protein 21A | 0.0282794 |
| TMEM51 | transmembrane protein 51 | 0.0282349 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0276076 |
| HLA-A | major histocompatibility complex, class I, A | 0.0275125 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0273985 |
| CRLS1 | cardiolipin synthase 1 | 0.0271712 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | 0.0268677 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.026756 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0267006 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0265107 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | 0.0264297 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.0261097 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0260298 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0254564 |
| NDRG1 | N-myc downstream regulated 1 | 0.0254217 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0254127 |
| RNF149 | ring finger protein 149 | 0.0251461 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0250496 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0248331 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0248178 |
| RPS27A | ribosomal protein S27a | 0.0248113 |
| AHR | aryl hydrocarbon receptor | 0.0247275 |
| CLTB | clathrin, light chain B | 0.0246564 |
| AFDN | afadin, adherens junction formation factor | 0.0242343 |
| UBC | ubiquitin C | 0.0242255 |
| LARP1 | La ribonucleoprotein domain family, member 1 | 0.0241894 |
| PHF3 | PHD finger protein 3 | 0.024178 |
| ARFGEF3 | ARFGEF family member 3 | 0.023993 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0239071 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | 0.0238709 |
| CENPF | centromere protein F, 350/400kDa | 0.0237612 |
| PDE8A | phosphodiesterase 8A | 0.0236469 |
| RBM6 | RNA binding motif protein 6 | 0.0235559 |
| MATN3 | matrilin 3 | 0.0234539 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0234206 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0233477 |
| DENND4A | DENN/MADD domain containing 4A | 0.0230824 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0229815 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.0229681 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.172874 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.131991 |
| GPC6 | glypican 6 | -0.128146 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.115806 |
| VCL | vinculin | -0.0898044 |
| RPL11 | ribosomal protein L11 | -0.0747539 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0720697 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0699512 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0673167 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0661108 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0653032 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0642366 |
| PCBP2 | poly(rC) binding protein 2 | -0.0604986 |
| INTS6 | integrator complex subunit 6 | -0.0596141 |
| ASPH | aspartate beta-hydroxylase | -0.0594514 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0588635 |
| RPS2 | ribosomal protein S2 | -0.0585683 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0560508 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0550628 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0545914 |
| RPS6 | ribosomal protein S6 | -0.0541544 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0535985 |
| RPS24 | ribosomal protein S24 | -0.0531051 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0510675 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0493385 |
| HPCAL1 | hippocalcin-like 1 | -0.0483351 |
| RPS8 | ribosomal protein S8 | -0.0475676 |
| SVIL | supervillin | -0.0475384 |
| RPLP0 | ribosomal protein, large, P0 | -0.046291 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0461017 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0449426 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0440443 |
| CLTC | clathrin, heavy chain (Hc) | -0.0439367 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0423724 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0416463 |
| DTNA | dystrobrevin, alpha | -0.0409999 |
| CANX | calnexin | -0.040837 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0405331 |
| RPL35A | ribosomal protein L35a | -0.0401822 |
| RPL9 | ribosomal protein L9 | -0.0399643 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0395933 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | -0.0395536 |
| RIGI | RNA sensor RIG-I | -0.0391388 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0383087 |
| JAK1 | Janus kinase 1 | -0.03816 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.037737 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0375767 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0374607 |
| RPL38 | ribosomal protein L38 | -0.0373403 |
| CLIC4 | chloride intracellular channel 4 | -0.0371727 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0369626 |
| EXOC6B | exocyst complex component 6B | -0.0368381 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.036823 |
| RNF213 | ring finger protein 213 | -0.0366238 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0363048 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0359819 |
| HDLBP | high density lipoprotein binding protein | -0.0356208 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0350562 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0348806 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0348661 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0348063 |
| MCU | mitochondrial calcium uniporter | -0.0346883 |
| TLE4 | transducin-like enhancer of split 4 | -0.0343543 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0341431 |
| RPL12 | ribosomal protein L12 | -0.0338436 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.033722 |
| A2M | alpha-2-macroglobulin | -0.0336862 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0332083 |
| RPL7 | ribosomal protein L7 | -0.0332006 |
| CP | ceruloplasmin (ferroxidase) | -0.0325515 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0320664 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0314207 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0312864 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0304863 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0303053 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0302127 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0301882 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.030141 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0300085 |
| KYNU | kynureninase | -0.0299437 |
| GPHN | gephyrin | -0.0298414 |
| SERTAD2 | SERTA domain containing 2 | -0.0297572 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0294268 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.02938 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0293707 |
| KIF21A | kinesin family member 21A | -0.0292817 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.029256 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0289864 |
| SH3GLB1 | SH3-domain GRB2-like endophilin B1 | -0.0288504 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0288275 |
| FAM107B | family with sequence similarity 107, member B | -0.028772 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.028615 |
| RPLP1 | ribosomal protein, large, P1 | -0.0284353 |
| MORF4L2 | mortality factor 4 like 2 | -0.0283834 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0281362 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0280661 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0279407 |
| FOXO3 | forkhead box O3 | -0.0274703 |
| RPLP2 | ribosomal protein, large, P2 | -0.0274698 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | -0.0273899 |
