Regorafenib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Regorafenib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Regorafenib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.175782
TIMP3 TIMP metallopeptidase inhibitor 3 0.159958
MEF2A myocyte enhancer factor 2A 0.124223
MTSS1 metastasis suppressor 1 0.114801
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0982877
ESYT2 extended synaptotagmin-like protein 2 0.0808562
RAI14 retinoic acid induced 14 0.069491
SLC35F3 solute carrier family 35, member F3 0.0658001
NAV2 neuron navigator 2 0.0637058
ABI3BP ABI family, member 3 (NESH) binding protein 0.0531874
LMO7 LIM domain 7 0.0522472
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0509891
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0493952
GRB10 growth factor receptor-bound protein 10 0.0473363
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.046829
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0452196
TRIO trio Rho guanine nucleotide exchange factor 0.0445938
SQLE squalene epoxidase 0.0443426
GOLGA4 golgin A4 0.0438258
PPARG peroxisome proliferator-activated receptor gamma 0.0437683
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0435614
CALB1 calbindin 1, 28kDa 0.0428851
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0421865
ITCH itchy E3 ubiquitin protein ligase 0.0413649
PDGFB platelet-derived growth factor beta polypeptide 0.0403867
PTK2 protein tyrosine kinase 2 0.0396019
BHLHE40 basic helix-loop-helix family, member e40 0.0393466
INSIG2 insulin induced gene 2 0.0381064
KMT2E lysine (K)-specific methyltransferase 2E 0.0380421
RICTOR RPTOR independent companion of MTOR, complex 2 0.0377972
ZCCHC7 zinc finger, CCHC domain containing 7 0.037358
UBA6 ubiquitin-like modifier activating enzyme 6 0.0366158
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0360825
NCOR2 nuclear receptor corepressor 2 0.0352089
FNIP1 folliculin interacting protein 1 0.0346524
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0343648
RNF217 ring finger protein 217 0.0342249
MEGF6 multiple EGF-like-domains 6 0.0338449
STC1 stanniocalcin 1 0.0333046
MYO10 myosin X 0.033095
PTMA prothymosin, alpha 0.0321532
CSNK1E casein kinase 1, epsilon 0.0320785
FOSL1 FOS-like antigen 1 0.032016
SUCO SUN domain containing ossification factor 0.031961
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0315105
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0311985
VEGFA vascular endothelial growth factor A 0.0309342
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0301678
OGA O-GlcNAcase 0.0301137
PLS3 plastin 3 0.0300836
KDM6A lysine (K)-specific demethylase 6A 0.0299493
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0298312
UBC ubiquitin C 0.0296924
NPEPPS aminopeptidase puromycin sensitive 0.0290039
ANO1 anoctamin 1, calcium activated chloride channel 0.0289291
RPS6 ribosomal protein S6 0.0283429
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0279577
PSD3 pleckstrin and Sec7 domain containing 3 0.0278194
ANGPTL4 angiopoietin-like 4 0.027816
RAI1 retinoic acid induced 1 0.0278055
COL17A1 collagen, type XVII, alpha 1 0.0276952
AKAP13 A kinase (PRKA) anchor protein 13 0.0275921
FRMD6 FERM domain containing 6 0.0274418
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0270034
MXI1 MAX interactor 1, dimerization protein 0.0266461
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0266372
ABLIM3 actin binding LIM protein family, member 3 0.0265416
SRP54 signal recognition particle 54kDa 0.026387
ZNF292 zinc finger protein 292 0.0261342
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0258471
MSN moesin 0.0256822
RASA3 RAS p21 protein activator 3 0.0255916
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0255166
BAIAP2L1 BAI1-associated protein 2-like 1 0.0253074
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0248514
TMEM165 transmembrane protein 165 0.0248143
FAM13A family with sequence similarity 13, member A 0.024653
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0245828
DYNC2I1 dynein 2 intermediate chain 1 0.0242952
DLG1 discs, large homolog 1 (Drosophila) 0.0241668
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0238398
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0236071
XPO1 exportin 1 0.0232635
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0231518
HSPG2 heparan sulfate proteoglycan 2 0.0225159
ENO1 enolase 1, (alpha) 0.0224865
ZNF395 zinc finger protein 395 0.0224551
KDM7A lysine (K)-specific demethylase 7A 0.0223875
SPAG9 sperm associated antigen 9 0.0220532
RNF145 ring finger protein 145 0.0216319
F3 coagulation factor III (thromboplastin, tissue factor) 0.0214172
BACE2 beta-site APP-cleaving enzyme 2 0.0213853
SLK STE20-like kinase 0.0213067
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0211868
ZMYM2 zinc finger, MYM-type 2 0.0211706
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.0211635
PYGL phosphorylase, glycogen, liver 0.020738
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0206748
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0206513
FKBP15 FK506 binding protein 15, 133kDa 0.0204317

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.151025
CLU clusterin -0.110177
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0964809
FOXO1 forkhead box O1 -0.0945662
TPT1 tumor protein, translationally-controlled 1 -0.093523
CD44 CD44 molecule (Indian blood group) -0.086669
MBNL1 muscleblind-like splicing regulator 1 -0.0838099
FOXP1 forkhead box P1 -0.0791725
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0786594
SULF1 sulfatase 1 -0.0761803
VCL vinculin -0.0739333
TMSB10 thymosin beta 10 -0.0665137
PLAT plasminogen activator, tissue -0.0616017
MECOM MDS1 and EVI1 complex locus -0.0614971
PALLD palladin, cytoskeletal associated protein -0.0592051
EXT1 exostosin glycosyltransferase 1 -0.0590313
NEK7 NIMA-related kinase 7 -0.0585533
NRG1 neuregulin 1 -0.0580461
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0578681
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0574335
AOPEP aminopeptidase O (putative) -0.0562271
OSMR oncostatin M receptor -0.0533814
BCL2L1 BCL2-like 1 -0.0526378
TXNRD1 thioredoxin reductase 1 -0.0508093
DPYD dihydropyrimidine dehydrogenase -0.0505574
FN1 fibronectin 1 -0.0502885
LOC112694756 uncharaterized LOC112694756 -0.0494476
ARHGAP29 Rho GTPase activating protein 29 -0.0487064
IFITM1 interferon induced transmembrane protein 1 -0.0475183
ITGA6 integrin, alpha 6 -0.0471361
PLEC plectin -0.0469046
AHNAK AHNAK nucleoprotein -0.0468124
PRELID2 PRELI domain containing 2 -0.0461513
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0457063
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0449522
ASPH aspartate beta-hydroxylase -0.044889
RIN2 Ras and Rab interactor 2 -0.0442841
B2M beta-2-microglobulin -0.0438055
ANKRD33B ankyrin repeat domain 33B -0.0430487
SAMD9 sterile alpha motif domain containing 9 -0.0429755
PDLIM5 PDZ and LIM domain 5 -0.0416696
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0414546
MT2A metallothionein 2A -0.0409098
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.040748
EXOC6B exocyst complex component 6B -0.0399321
KRT6A keratin 6A, type II -0.0395615
MYOF myoferlin -0.0392664
CAV1 caveolin 1, caveolae protein, 22kDa -0.0390389
NCOA3 nuclear receptor coactivator 3 -0.0390174
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0388193
IFITM3 interferon induced transmembrane protein 3 -0.0385997
CEMIP cell migration inducing protein, hyaluronan binding -0.0384965
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0368439
FLNA filamin A, alpha -0.0367458
RPLP2 ribosomal protein, large, P2 -0.0365171
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0361094
DST dystonin -0.0360482
ZNFX1 zinc finger, NFX1-type containing 1 -0.0356506
RPL12 ribosomal protein L12 -0.0353287
RPS3 ribosomal protein S3 -0.0345236
RPL11 ribosomal protein L11 -0.0344063
ANXA2 annexin A2 -0.0339718
CLIC4 chloride intracellular channel 4 -0.0339146
HLA-B major histocompatibility complex, class I, B -0.0333224
HDLBP high density lipoprotein binding protein -0.032869
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0325517
SFTPA2 surfactant protein A2 -0.0323851
OSBPL3 oxysterol binding protein-like 3 -0.0322953
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0321087
RPS19 ribosomal protein S19 -0.0314172
SERINC3 serine incorporator 3 -0.0313386
ADAR adenosine deaminase, RNA-specific -0.0306686
ARF1 ADP-ribosylation factor 1 -0.0304871
KRT17 keratin 17, type I -0.0304636
PPIA peptidylprolyl isomerase A (cyclophilin A) -0.030428
EFNA5 ephrin-A5 -0.0302228
RIGI RNA sensor RIG-I -0.0298274
SP100 SP100 nuclear antigen -0.0293461
APP amyloid beta (A4) precursor protein -0.0287775
SEPTIN11 septin 11 -0.0284914
TKT transketolase -0.0284301
RPS21 ribosomal protein S21 -0.0283779
MYH9 myosin, heavy chain 9, non-muscle -0.0283296
RPL7 ribosomal protein L7 -0.028133
TMSB4X thymosin beta 4, X-linked -0.0278244
SMAD3 SMAD family member 3 -0.027633
RPL28 ribosomal protein L28 -0.0275727
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0273017
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0272578
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0272523
EEF2 eukaryotic translation elongation factor 2 -0.0272487
SEPTIN9 septin 9 -0.0271025
EGFR epidermal growth factor receptor -0.0270728
TJP1 tight junction protein 1 -0.0269667
SMYD3 SET and MYND domain containing 3 -0.0267213
ARCN1 archain 1 -0.0266204
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0264095
DOCK5 dedicator of cytokinesis 5 -0.0262319
MTAP methylthioadenosine phosphorylase -0.0261637
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.026083