| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Regorafenib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Regorafenib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.118759 |
| FAM13A | family with sequence similarity 13, member A | 0.105449 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0924924 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0861372 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0822769 |
| UBC | ubiquitin C | 0.0812495 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0732257 |
| NDRG1 | N-myc downstream regulated 1 | 0.0731674 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0694501 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0686386 |
| H1-0 | H1.0 linker histone | 0.0667201 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0664277 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0661988 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0591236 |
| GRAMD1B | GRAM domain containing 1B | 0.0580515 |
| TMSB10 | thymosin beta 10 | 0.0575922 |
| STC1 | stanniocalcin 1 | 0.0551086 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0541432 |
| SEC61G | Sec61 gamma subunit | 0.0527795 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.052051 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0498616 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0470275 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0451516 |
| TMEM165 | transmembrane protein 165 | 0.0424127 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.04163 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0411854 |
| PKM | pyruvate kinase, muscle | 0.0390952 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0389639 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0386406 |
| RPL4 | ribosomal protein L4 | 0.0382689 |
| MT2A | metallothionein 2A | 0.0380899 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.037809 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0370925 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.037087 |
| RNF145 | ring finger protein 145 | 0.0359542 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0352816 |
| SMAD3 | SMAD family member 3 | 0.0347872 |
| CST3 | cystatin C | 0.0343326 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0338785 |
| CDCP1 | CUB domain containing protein 1 | 0.032906 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0324901 |
| AREG | amphiregulin | 0.0323466 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0322872 |
| CES1 | carboxylesterase 1 | 0.0322825 |
| SDC4 | syndecan 4 | 0.030792 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0303477 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0296678 |
| CPE | carboxypeptidase E | 0.0294827 |
| SLMAP | sarcolemma associated protein | 0.0294666 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0290444 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0290336 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.028686 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0284533 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0279381 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0278805 |
| MSN | moesin | 0.0276114 |
| PDE8A | phosphodiesterase 8A | 0.0274291 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.027003 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0265309 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0263177 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0254403 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0251921 |
| TPD52 | tumor protein D52 | 0.0249694 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.024921 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0248948 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0246411 |
| CTSL | cathepsin L | 0.0245128 |
| NGLY1 | N-glycanase 1 | 0.0244616 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0242356 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0240041 |
| CD163L1 | CD163 molecule-like 1 | 0.0238976 |
| USP34 | ubiquitin specific peptidase 34 | 0.0231541 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.023037 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0228789 |
| RNF149 | ring finger protein 149 | 0.0227326 |
| TMEM45B | transmembrane protein 45B | 0.022695 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0223987 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0222637 |
| ZNF292 | zinc finger protein 292 | 0.02218 |
| RREB1 | ras responsive element binding protein 1 | 0.0221038 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.0220175 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0219523 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0217883 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0216358 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0216045 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0215925 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0215321 |
| EFNA5 | ephrin-A5 | 0.0214389 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0214283 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0213347 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0213055 |
| ATG7 | autophagy related 7 | 0.0210753 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0209863 |
| PTMA | prothymosin, alpha | 0.0206184 |
| RNF24 | ring finger protein 24 | 0.020444 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0201381 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.020009 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0199558 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0192802 |
| S100A9 | S100 calcium binding protein A9 | 0.0192302 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.242949 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.21224 |
| HDLBP | high density lipoprotein binding protein | -0.0726283 |
| TES | testin LIM domain protein | -0.0720463 |
| TXNRD1 | thioredoxin reductase 1 | -0.071304 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0643631 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0586474 |
| ANXA2 | annexin A2 | -0.0578938 |
| PCBP2 | poly(rC) binding protein 2 | -0.0568982 |
| MYOF | myoferlin | -0.0552232 |
| RPS3 | ribosomal protein S3 | -0.0544511 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0527057 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0514371 |
| CANX | calnexin | -0.0484323 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0481634 |
| LDHA | lactate dehydrogenase A | -0.0447669 |
| VCL | vinculin | -0.0440896 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0423123 |
| ASPH | aspartate beta-hydroxylase | -0.0420081 |
| GOLGB1 | golgin B1 | -0.0418424 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0416502 |
| EXT1 | exostosin glycosyltransferase 1 | -0.041438 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0372674 |
| HYOU1 | hypoxia up-regulated 1 | -0.0357138 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.035264 |
| MORF4L2 | mortality factor 4 like 2 | -0.035208 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0348671 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0325699 |
| JAK1 | Janus kinase 1 | -0.0308994 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0294975 |
| RPL35A | ribosomal protein L35a | -0.0294901 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0284096 |
| NABP1 | nucleic acid binding protein 1 | -0.0283535 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0279982 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0274379 |
| PLEC | plectin | -0.0273057 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0269895 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0268143 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0266041 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0265099 |
| RPS12 | ribosomal protein S12 | -0.0255422 |
| SMYD3 | SET and MYND domain containing 3 | -0.0254464 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0253321 |
| MGAT4C | MGAT4 family, member C | -0.0251332 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0251323 |
| MKI67 | marker of proliferation Ki-67 | -0.0250373 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.024797 |
| RPL8 | ribosomal protein L8 | -0.0245296 |
| CEP350 | centrosomal protein 350kDa | -0.0243818 |
| RPL11 | ribosomal protein L11 | -0.0243276 |
| RPLP0 | ribosomal protein, large, P0 | -0.0242754 |
| RPL7 | ribosomal protein L7 | -0.0242344 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0241725 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0241509 |
| LRP12 | low density lipoprotein receptor-related protein 12 | -0.0237038 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0236206 |
| TMCO3 | transmembrane and coiled-coil domains 3 | -0.0233024 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0231071 |
| ARCN1 | archain 1 | -0.0227079 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0224595 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0223042 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0221389 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0219466 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0217988 |
| RPL31 | ribosomal protein L31 | -0.0215814 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0215295 |
| RACK1 | receptor for activated C kinase 1 | -0.0213895 |
| DSPP | dentin sialophosphoprotein | -0.0213344 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0212976 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0210925 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0210717 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0209799 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0208447 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0207663 |
| GM2A | GM2 ganglioside activator | -0.020721 |
| MLEC | malectin | -0.0205642 |
| INTS6 | integrator complex subunit 6 | -0.0205509 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.0204999 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0204628 |
| RPL12 | ribosomal protein L12 | -0.0202905 |
| JMJD1C | jumonji domain containing 1C | -0.0201612 |
| SEPTIN2 | septin 2 | -0.0201392 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0200861 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.019987 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.0199566 |
| ARGLU1 | arginine and glutamate rich 1 | -0.0198302 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0198257 |
| SLTM | SAFB-like, transcription modulator | -0.0198241 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0198173 |
| KIAA1328 | KIAA1328 | -0.0193311 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0190513 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0189087 |
| KIAA0232 | KIAA0232 | -0.0187816 |
| PRELID2 | PRELI domain containing 2 | -0.0185539 |
| MYO9A | myosin IXA | -0.0185137 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0184539 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0184417 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | -0.0183472 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0182505 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0179898 |
