| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Regorafenib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Regorafenib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.127672 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.113404 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0938531 |
| USP34 | ubiquitin specific peptidase 34 | 0.0822141 |
| FAM13A | family with sequence similarity 13, member A | 0.0770505 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0562826 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0491828 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0489558 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0475255 |
| UBC | ubiquitin C | 0.046734 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0462937 |
| SETD5 | SET domain containing 5 | 0.0453311 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0447195 |
| VEGFA | vascular endothelial growth factor A | 0.0443113 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0429289 |
| CA12 | carbonic anhydrase XII | 0.0413046 |
| SMAD3 | SMAD family member 3 | 0.0401495 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0394864 |
| ZNF292 | zinc finger protein 292 | 0.0385269 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0382977 |
| NGLY1 | N-glycanase 1 | 0.0378423 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0375484 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0371873 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0367932 |
| LRRC8C | leucine rich repeat containing 8 family, member C | 0.0357669 |
| OPTN | optineurin | 0.0355427 |
| VMP1 | vacuole membrane protein 1 | 0.034806 |
| TMEM165 | transmembrane protein 165 | 0.0343009 |
| GRB10 | growth factor receptor-bound protein 10 | 0.033565 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0333726 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0332153 |
| NDRG1 | N-myc downstream regulated 1 | 0.0330773 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0328809 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.032765 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0326547 |
| MYO1B | myosin IB | 0.0317454 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0313739 |
| MEF2A | myocyte enhancer factor 2A | 0.0312283 |
| PHF21A | PHD finger protein 21A | 0.0311139 |
| RUNX2 | runt-related transcription factor 2 | 0.0306169 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0305887 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0301214 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0298751 |
| PFKP | phosphofructokinase, platelet | 0.0293292 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.028983 |
| YEATS2 | YEATS domain containing 2 | 0.0289033 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0287981 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0281479 |
| RNF24 | ring finger protein 24 | 0.0281065 |
| ADAM28 | ADAM metallopeptidase domain 28 | 0.0274375 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0273262 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.02719 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0270981 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0270831 |
| PRELID2 | PRELI domain containing 2 | 0.0270583 |
| PLIN2 | perilipin 2 | 0.0266496 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0258694 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0257478 |
| GPC6 | glypican 6 | 0.0257151 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0256601 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | 0.025553 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0255273 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0254029 |
| PTEN | phosphatase and tensin homolog | 0.0252693 |
| CDK19 | cyclin-dependent kinase 19 | 0.024998 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0249318 |
| FN1 | fibronectin 1 | 0.0247989 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0247197 |
| ETV6 | ets variant 6 | 0.0246933 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0246577 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.024637 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.024629 |
| ATP13A3 | ATPase type 13A3 | 0.0242375 |
| SRP54 | signal recognition particle 54kDa | 0.0238819 |
| DST | dystonin | 0.0235403 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0233735 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0232759 |
| PRKAR1B | protein kinase, cAMP-dependent, regulatory, type I, beta | 0.023207 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0231855 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0230456 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0229078 |
| MLPH | melanophilin | 0.0223783 |
| C1R | complement component 1, r subcomponent | 0.0222574 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0222251 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0219809 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0219477 |
| TP53BP1 | tumor protein p53 binding protein 1 | 0.0217686 |
| FLNB | filamin B, beta | 0.0216226 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.0214058 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0212477 |
| RAD51B | RAD51 paralog B | 0.0212283 |
| ANO6 | anoctamin 6 | 0.0211891 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0211674 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0211519 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0210812 |
| THOC2 | THO complex 2 | 0.0207919 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0207338 |
| DNER | delta/notch-like EGF repeat containing | 0.0206 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0203634 |
| FAM120A | family with sequence similarity 120A | 0.0202267 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.31307 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.204714 |
| CD44 | CD44 molecule (Indian blood group) | -0.171218 |
| TMSB10 | thymosin beta 10 | -0.143476 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.121436 |
| PCBP2 | poly(rC) binding protein 2 | -0.110343 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.097213 |
| FTL | ferritin, light polypeptide | -0.0899795 |
| CANX | calnexin | -0.0772977 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0767983 |
| CDH13 | cadherin 13 | -0.0749319 |
| RPLP0 | ribosomal protein, large, P0 | -0.0657709 |
| RPL35A | ribosomal protein L35a | -0.0637577 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0613665 |
| RPLP1 | ribosomal protein, large, P1 | -0.0600491 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0582786 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0571176 |
| GLCCI1 | glucocorticoid induced 1 | -0.0558605 |
| TMSB4X | thymosin beta 4, X-linked | -0.0513846 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0494353 |
| RPS24 | ribosomal protein S24 | -0.0483834 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0472184 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0462263 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0452937 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0452665 |
| HMGA1 | high mobility group AT-hook 1 | -0.0448311 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0442364 |
| VIM | vimentin | -0.0442287 |
| IER3 | immediate early response 3 | -0.0426483 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0415279 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0403625 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0402431 |
| LOX | lysyl oxidase | -0.0399473 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0397821 |
| MT2A | metallothionein 2A | -0.0391307 |
| RPL11 | ribosomal protein L11 | -0.038985 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0387094 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0381013 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0380959 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0380481 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0379079 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0378159 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0375601 |
| RPL23 | ribosomal protein L23 | -0.0375461 |
| RPL34 | ribosomal protein L34 | -0.0372877 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0366453 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0363329 |
| HDLBP | high density lipoprotein binding protein | -0.0362609 |
| RPL12 | ribosomal protein L12 | -0.0356896 |
| YBX1 | Y box binding protein 1 | -0.0349765 |
| PTMA | prothymosin, alpha | -0.0344752 |
| ARF1 | ADP-ribosylation factor 1 | -0.0344448 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0341615 |
| EXT1 | exostosin glycosyltransferase 1 | -0.033397 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0332332 |
| EIF4H | eukaryotic translation initiation factor 4H | -0.0328957 |
| TXNRD1 | thioredoxin reductase 1 | -0.0327885 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0326034 |
| ASPH | aspartate beta-hydroxylase | -0.0325862 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0325365 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0322613 |
| AHNAK | AHNAK nucleoprotein | -0.0320651 |
| NRP1 | neuropilin 1 | -0.031572 |
| RPL37 | ribosomal protein L37 | -0.0309962 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0308806 |
| VCL | vinculin | -0.0306078 |
| HBP1 | HMG-box transcription factor 1 | -0.030582 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0304707 |
| CALU | calumenin | -0.0299739 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0296466 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0295741 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0295653 |
| MORF4L2 | mortality factor 4 like 2 | -0.0295622 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0295202 |
| RPL7 | ribosomal protein L7 | -0.029436 |
| S100A10 | S100 calcium binding protein A10 | -0.0293926 |
| FBXO11 | F-box protein 11 | -0.0293157 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.029298 |
| NRG1 | neuregulin 1 | -0.0290613 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0290571 |
| RPL32 | ribosomal protein L32 | -0.0289441 |
| RPS21 | ribosomal protein S21 | -0.0288236 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0288111 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.02826 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0280494 |
| TKT | transketolase | -0.0280285 |
| RPS11 | ribosomal protein S11 | -0.0278126 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0276594 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0275361 |
| TJP1 | tight junction protein 1 | -0.0274493 |
| RPS19 | ribosomal protein S19 | -0.0273404 |
| STC1 | stanniocalcin 1 | -0.0268983 |
| TMEM263 | transmembrane protein 263 | -0.0268801 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0266878 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0264431 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0261204 |
| DTNA | dystrobrevin, alpha | -0.0260986 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0260709 |
| MED13L | mediator complex subunit 13-like | -0.0260184 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0259709 |
