| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Regorafenib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Regorafenib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.20584 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.115987 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.110494 |
| TXNRD1 | thioredoxin reductase 1 | 0.10396 |
| IGF2 | insulin-like growth factor 2 | 0.0989545 |
| GRAMD1B | GRAM domain containing 1B | 0.0874646 |
| SLC38A2 | solute carrier family 38, member 2 | 0.079195 |
| FGB | fibrinogen beta chain | 0.0625817 |
| CCNL1 | cyclin L1 | 0.0625535 |
| WDR43 | WD repeat domain 43 | 0.0574148 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0538535 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0513195 |
| PTK2 | protein tyrosine kinase 2 | 0.0507921 |
| YBX3 | Y box binding protein 3 | 0.0494167 |
| LDHA | lactate dehydrogenase A | 0.0485032 |
| PTMA | prothymosin, alpha | 0.0483372 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0440705 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0418432 |
| HDAC9 | histone deacetylase 9 | 0.0416914 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0416861 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0415783 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0410331 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0405051 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0404698 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0403785 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0395386 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0392839 |
| STC1 | stanniocalcin 1 | 0.0388469 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.038602 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0382671 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.037183 |
| UTRN | utrophin | 0.036994 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0361326 |
| TPD52 | tumor protein D52 | 0.0358408 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.03527 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0348966 |
| USP3 | ubiquitin specific peptidase 3 | 0.034754 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0346377 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0346299 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0340928 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0339438 |
| ACACA | acetyl-CoA carboxylase alpha | 0.0337353 |
| RASAL2 | RAS protein activator like 2 | 0.0334866 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0332704 |
| ACTG1 | actin gamma 1 | 0.0319306 |
| KLF6 | Kruppel-like factor 6 | 0.0318119 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0311431 |
| NUP58 | nucleoporin 58 | 0.0309301 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0307388 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0305517 |
| YME1L1 | YME1-like 1 ATPase | 0.0303156 |
| FLNB | filamin B, beta | 0.0303125 |
| ANXA1 | annexin A1 | 0.029636 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0292598 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0287979 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0283554 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0281392 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0281318 |
| NOL10 | nucleolar protein 10 | 0.0280781 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0280669 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.027963 |
| ENO1 | enolase 1, (alpha) | 0.027397 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.027064 |
| RNF145 | ring finger protein 145 | 0.0265027 |
| DST | dystonin | 0.0264153 |
| RPL4 | ribosomal protein L4 | 0.0263948 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.026177 |
| WBP11 | WW domain binding protein 11 | 0.0256902 |
| THBS1 | thrombospondin 1 | 0.0256003 |
| ERBIN | erbb2 interacting protein | 0.0255953 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.025405 |
| RBM25 | RNA binding motif protein 25 | 0.0253389 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0251544 |
| MCL1 | myeloid cell leukemia 1 | 0.0251441 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0250379 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0245727 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0244801 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0244586 |
| VMP1 | vacuole membrane protein 1 | 0.0244168 |
| ANLN | anillin, actin binding protein | 0.0243445 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0241588 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0240769 |
| CHN1 | chimerin 1 | 0.0240637 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0238903 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0238824 |
| RBM8A | RNA binding motif protein 8A | 0.0237629 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0236811 |
| BICC1 | BicC family RNA binding protein 1 | 0.0234077 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0232157 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0231641 |
| MKI67 | marker of proliferation Ki-67 | 0.0229681 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0229157 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0228969 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0227968 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0227494 |
| CASC3 | cancer susceptibility candidate 3 | 0.0224723 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0222335 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0220682 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0219105 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0218787 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.217341 |
| TMSB10 | thymosin beta 10 | -0.148612 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0782508 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0747216 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0726246 |
| RPLP1 | ribosomal protein, large, P1 | -0.0689515 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0625848 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0567956 |
| VIM | vimentin | -0.0561744 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0550884 |
| RPL35A | ribosomal protein L35a | -0.0464613 |
| RPS12 | ribosomal protein S12 | -0.045735 |
| PCBP2 | poly(rC) binding protein 2 | -0.0444239 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0440932 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0420178 |
| RPL37 | ribosomal protein L37 | -0.0405513 |
| RPS20 | ribosomal protein S20 | -0.0397997 |
| VCL | vinculin | -0.0392738 |
| RPL30 | ribosomal protein L30 | -0.0390486 |
| FTL | ferritin, light polypeptide | -0.0380288 |
| RPL31 | ribosomal protein L31 | -0.0359655 |
| RPS8 | ribosomal protein S8 | -0.0352828 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0352284 |
| RPL23 | ribosomal protein L23 | -0.0348839 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0338254 |
| RPL37A | ribosomal protein L37a | -0.0336801 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0335107 |
| RPL28 | ribosomal protein L28 | -0.0332698 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.033133 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0328536 |
| MORF4L2 | mortality factor 4 like 2 | -0.032786 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0323858 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0322833 |
| RPS17 | ribosomal protein S17 | -0.0321597 |
| TPM3 | tropomyosin 3 | -0.0319645 |
| MYOF | myoferlin | -0.0316577 |
| RPL36 | ribosomal protein L36 | -0.0312316 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0308837 |
| HLA-A | major histocompatibility complex, class I, A | -0.0300923 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0291571 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0290904 |
| CUL3 | cullin 3 | -0.0285538 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0284082 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0283825 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0283246 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0282869 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0282531 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0280999 |
| ACTN1 | actinin, alpha 1 | -0.0279332 |
| RPS24 | ribosomal protein S24 | -0.0277564 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0277245 |
| PCNX4 | pecanex 4 | -0.0276779 |
| RPL13A | ribosomal protein L13a | -0.0274911 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0273852 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0273807 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0271057 |
| HLA-B | major histocompatibility complex, class I, B | -0.0266737 |
| HM13 | histocompatibility (minor) 13 | -0.0259612 |
| RPS19 | ribosomal protein S19 | -0.0255124 |
| RPL11 | ribosomal protein L11 | -0.0254673 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0253063 |
| RPL26 | ribosomal protein L26 | -0.0251899 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0251663 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0246922 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0245921 |
| RPL34 | ribosomal protein L34 | -0.0243599 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0242141 |
| ATF4 | activating transcription factor 4 | -0.0241813 |
| RPL9 | ribosomal protein L9 | -0.0241496 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0240542 |
| RUNX1 | runt-related transcription factor 1 | -0.0240491 |
| RPS21 | ribosomal protein S21 | -0.0236828 |
| MT1X | metallothionein 1X | -0.023511 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.023426 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0232703 |
| CDK13 | cyclin-dependent kinase 13 | -0.0231538 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0231467 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0231343 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0227702 |
| FBXO11 | F-box protein 11 | -0.0223842 |
| JMJD1C | jumonji domain containing 1C | -0.0223259 |
| RPS27 | ribosomal protein S27 | -0.0221967 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.02195 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -0.0218683 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0215549 |
| RAB22A | RAB22A, member RAS oncogene family | -0.0214767 |
| RPS16 | ribosomal protein S16 | -0.0214609 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | -0.0214288 |
| NNMT | nicotinamide N-methyltransferase | -0.0214169 |
| FLNA | filamin A, alpha | -0.0213924 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0213072 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0208062 |
| RPL36A | ribosomal protein L36a | -0.0208018 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0206105 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0206104 |
| S100A10 | S100 calcium binding protein A10 | -0.020605 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0204459 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0203913 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.0203739 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0203693 |
