Regorafenib_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Regorafenib perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Regorafenib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.179946
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.13548
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.129865
PDE4D phosphodiesterase 4D, cAMP-specific 0.120607
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.12058
ELL2 elongation factor, RNA polymerase II, 2 0.120307
ERRFI1 ERBB receptor feedback inhibitor 1 0.10651
FNDC3B fibronectin type III domain containing 3B 0.101919
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0994686
DSCAM Down syndrome cell adhesion molecule 0.0918226
FN1 fibronectin 1 0.0849271
FAM13A family with sequence similarity 13, member A 0.0833619
HOOK2 hook microtubule-tethering protein 2 0.082495
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0807897
KDM6A lysine (K)-specific demethylase 6A 0.0719826
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0696324
TSC22D2 TSC22 domain family, member 2 0.068889
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0686651
OGA O-GlcNAcase 0.0631243
VEGFA vascular endothelial growth factor A 0.060645
ESYT2 extended synaptotagmin-like protein 2 0.0568981
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.056713
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0557154
RYBP RING1 and YY1 binding protein 0.0527544
NAMPT nicotinamide phosphoribosyltransferase 0.050878
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0508182
FNDC3A fibronectin type III domain containing 3A 0.0506412
H2AC6 H2A clustered histone 6 0.0497065
MATR3 matrin 3 0.0495602
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0487646
CD109 CD109 molecule 0.0483047
BHLHE40 basic helix-loop-helix family, member e40 0.0477565
SDC4 syndecan 4 0.0464117
MIMS1 mitochondrial inner membrane scaffold 1 0.0451841
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0444519
TFG TRK-fused gene 0.0441282
GRB10 growth factor receptor-bound protein 10 0.0436856
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0432551
STC1 stanniocalcin 1 0.0426214
PUM2 pumilio RNA-binding family member 2 0.0420292
ZMYND8 zinc finger, MYND-type containing 8 0.041849
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0416958
KMT2E lysine (K)-specific methyltransferase 2E 0.0413974
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0409639
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0409253
ZNF292 zinc finger protein 292 0.0405021
IL1A interleukin 1, alpha 0.040249
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0402245
SETD5 SET domain containing 5 0.0395781
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.039179
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0388472
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0386019
ITPRID2 ITPR interacting domain containing 2 0.0385965
BIRC6 baculoviral IAP repeat containing 6 0.038185
EFNA5 ephrin-A5 0.0381169
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0374638
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0368875
SND1 staphylococcal nuclease and tudor domain containing 1 0.0367337
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0366741
SLMAP sarcolemma associated protein 0.0365967
RORA RAR-related orphan receptor A 0.0357256
PHF3 PHD finger protein 3 0.0355716
SPAG9 sperm associated antigen 9 0.0353209
MCL1 myeloid cell leukemia 1 0.0352533
RSAD2 radical S-adenosyl methionine domain containing 2 0.0350778
SEC24D SEC24 family member D 0.0348822
SSBP2 single-stranded DNA binding protein 2 0.0343663
RBBP6 retinoblastoma binding protein 6 0.0343591
SEC63 SEC63 homolog (S. cerevisiae) 0.034326
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0342036
NCKAP1 NCK-associated protein 1 0.0339832
WDFY3 WD repeat and FYVE domain containing 3 0.033961
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.033566
FOXJ3 forkhead box J3 0.0332321
PDIA6 protein disulfide isomerase family A, member 6 0.0331931
MTUS1 microtubule associated tumor suppressor 1 0.0330494
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0329518
LOC102724023 ES1 protein homolog, mitochondrial 0.0327513
NALF1 NALCN channel auxiliary factor 1 0.0325924
SEC31A SEC31 homolog A (S. cerevisiae) 0.0325242
COPA coatomer protein complex, subunit alpha 0.032329
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0322644
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0322528
RICTOR RPTOR independent companion of MTOR, complex 2 0.0322259
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0319634
KDM3A lysine (K)-specific demethylase 3A 0.0318222
HLA-A major histocompatibility complex, class I, A 0.0316248
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.031548
FLNB filamin B, beta 0.0314549
SET SET nuclear proto-oncogene 0.0311345
CYTH1 cytohesin 1 0.0308696
MBNL2 muscleblind-like splicing regulator 2 0.0307357
GRAMD2B GRAM domain containing 2B 0.0306786
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0306233
FNIP1 folliculin interacting protein 1 0.0305727
ZNF207 zinc finger protein 207 0.0302483
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0299949
TRA2A transformer 2 alpha homolog (Drosophila) 0.0299641
FAM162A family with sequence similarity 162, member A 0.0298795
CXCL8 chemokine (C-X-C motif) ligand 8 0.0296959

decreased expression

Symbol Name Standardized Value
MYO1E myosin IE -0.195988
LMO7 LIM domain 7 -0.124316
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.109781
LAMC2 laminin, gamma 2 -0.109096
SAMD4A sterile alpha motif domain containing 4A -0.100255
CEMIP cell migration inducing protein, hyaluronan binding -0.0932932
EXT1 exostosin glycosyltransferase 1 -0.0865889
IGF1R insulin-like growth factor 1 receptor -0.0813107
SMOC1 SPARC related modular calcium binding 1 -0.0783515
LAMB3 laminin, beta 3 -0.0737207
BACE2 beta-site APP-cleaving enzyme 2 -0.0736456
SVIL supervillin -0.0720908
VCL vinculin -0.0717482
CMIP c-Maf inducing protein -0.0714216
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0701264
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.069454
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0679661
BMAL2 basic helix-loop-helix ARNT like 2 -0.0674684
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.065069
RBM47 RNA binding motif protein 47 -0.0638322
TXNRD1 thioredoxin reductase 1 -0.0592882
PLAUR plasminogen activator, urokinase receptor -0.0586986
TPT1 tumor protein, translationally-controlled 1 -0.056924
LIMCH1 LIM and calponin homology domains 1 -0.0561461
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0552439
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0537798
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0537356
CATSPERB catsper channel auxiliary subunit beta -0.053596
EZR ezrin -0.0531768
SPDYA speedy/RINGO cell cycle regulator family member A -0.0522441
SSH2 slingshot protein phosphatase 2 -0.0499813
KTN1 kinectin 1 (kinesin receptor) -0.0497029
ANXA2 annexin A2 -0.047557
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0467083
ATOSA atos homolog A -0.0466731
PATJ PATJ crumbs cell polarity complex component -0.0466087
SGMS2 sphingomyelin synthase 2 -0.0460123
KRT17 keratin 17, type I -0.0458107
ACTG1 actin gamma 1 -0.0448261
SQSTM1 sequestosome 1 -0.0447551
LDHA lactate dehydrogenase A -0.0444639
VIM vimentin -0.0437371
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0434546
SMYD3 SET and MYND domain containing 3 -0.0425458
TJP1 tight junction protein 1 -0.0425236
INTS6 integrator complex subunit 6 -0.042502
OSBPL3 oxysterol binding protein-like 3 -0.0424888
WASL Wiskott-Aldrich syndrome-like -0.0421068
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0415261
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0413358
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0407947
KIF13B kinesin family member 13B -0.0406694
RESF1 retroelement silencing factor 1 -0.0404334
AK1 adenylate kinase 1 -0.0402966
EGFR epidermal growth factor receptor -0.0402195
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0391022
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0386611
SETX senataxin -0.0378401
ETV6 ets variant 6 -0.0377772
MRPS6 mitochondrial ribosomal protein S6 -0.0375685
ADAM10 ADAM metallopeptidase domain 10 -0.037384
ANTXR2 anthrax toxin receptor 2 -0.0367236
ARHGAP21 Rho GTPase activating protein 21 -0.0363073
MUC16 mucin 16, cell surface associated -0.0359192
IGFBP3 insulin-like growth factor binding protein 3 -0.0355054
GLUL glutamate-ammonia ligase -0.0354756
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0351923
CAMTA1 calmodulin binding transcription activator 1 -0.0351586
RAB10 RAB10, member RAS oncogene family -0.0350469
PARD6B par-6 family cell polarity regulator beta -0.0349519
STEAP4 STEAP family member 4 -0.034935
AKAP13 A kinase (PRKA) anchor protein 13 -0.0349071
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.0342035
FTL ferritin, light polypeptide -0.0341605
NLGN1 neuroligin 1 -0.0341459
FBXO34 F-box protein 34 -0.0338574
RAI14 retinoic acid induced 14 -0.0338314
ZFAND6 zinc finger, AN1-type domain 6 -0.033792
JUP junction plakoglobin -0.0337802
TMSB10 thymosin beta 10 -0.0337776
DLG1 discs, large homolog 1 (Drosophila) -0.0336076
FOXO3 forkhead box O3 -0.0335261
GLCCI1 glucocorticoid induced 1 -0.0335026
TPM4 tropomyosin 4 -0.033318
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0328581
ANKRD36C ankyrin repeat domain 36C -0.0327516
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0327044
AKAP9 A kinase (PRKA) anchor protein 9 -0.0313147
GPBP1L1 GC-rich promoter binding protein 1-like 1 -0.0312985
ANKRD17 ankyrin repeat domain 17 -0.0311226
EGR1 early growth response 1 -0.0311082
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0309393
AHNAK AHNAK nucleoprotein -0.0302235
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0301055
TUFT1 tuftelin 1 -0.0297732
DCAF7 DDB1 and CUL4 associated factor 7 -0.0297137
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0296998
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0296934
GOLGB1 golgin B1 -0.0296801
NCOR2 nuclear receptor corepressor 2 -0.0296144