| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Regorafenib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Regorafenib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.205344 |
| RAD51B | RAD51 paralog B | 0.108679 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0916173 |
| MCL1 | myeloid cell leukemia 1 | 0.0697291 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0683108 |
| KRT18 | keratin 18, type I | 0.0675136 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0657843 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0635609 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0591986 |
| PRELID2 | PRELI domain containing 2 | 0.0573911 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0540599 |
| HDGF | hepatoma-derived growth factor | 0.0503241 |
| ATXN1 | ataxin 1 | 0.048828 |
| LDHA | lactate dehydrogenase A | 0.0488256 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0480266 |
| PFKP | phosphofructokinase, platelet | 0.0465958 |
| NUP58 | nucleoporin 58 | 0.0431388 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0429585 |
| CCNL1 | cyclin L1 | 0.0414925 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0414862 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.041432 |
| IGF2 | insulin-like growth factor 2 | 0.0410695 |
| FMNL2 | formin-like 2 | 0.0388142 |
| VIM | vimentin | 0.0385392 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0374916 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0372476 |
| PTMA | prothymosin, alpha | 0.0370243 |
| POTEF | POTE ankyrin domain family, member F | 0.0355292 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0354329 |
| EGR1 | early growth response 1 | 0.0348536 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0342545 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0341501 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0340836 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0327247 |
| PCBP2 | poly(rC) binding protein 2 | 0.0326848 |
| PNN | pinin, desmosome associated protein | 0.0322263 |
| CENPF | centromere protein F, 350/400kDa | 0.0321834 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0320944 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0301852 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0296668 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0296032 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0295687 |
| TPM3 | tropomyosin 3 | 0.0293408 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0291304 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0291191 |
| NDRG1 | N-myc downstream regulated 1 | 0.0291106 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0290171 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0288662 |
| RYR3 | ryanodine receptor 3 | 0.0288553 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0285716 |
| DST | dystonin | 0.0284121 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0282228 |
| FAM120A | family with sequence similarity 120A | 0.0274242 |
| DENND1A | DENN/MADD domain containing 1A | 0.0268459 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0260655 |
| PFN1 | profilin 1 | 0.0260459 |
| MSH2 | mutS homolog 2 | 0.0258989 |
| SET | SET nuclear proto-oncogene | 0.0255969 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0255453 |
| TPM4 | tropomyosin 4 | 0.025503 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0254945 |
| WWOX | WW domain containing oxidoreductase | 0.0248277 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0241413 |
| CEP250 | centrosomal protein 250kDa | 0.0241099 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.023651 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0234946 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0234819 |
| EXOC4 | exocyst complex component 4 | 0.0232201 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | 0.0230785 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | 0.0230461 |
| BAG6 | BCL2-associated athanogene 6 | 0.0230385 |
| HCFC1 | host cell factor C1 | 0.0228892 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0226898 |
| SBF2 | SET binding factor 2 | 0.0222337 |
| CDCP1 | CUB domain containing protein 1 | 0.0220803 |
| TUBA1B | tubulin, alpha 1b | 0.0219774 |
| DSPP | dentin sialophosphoprotein | 0.0217076 |
| HMGB1 | high mobility group box 1 | 0.0216923 |
| SRSF3 | serine/arginine-rich splicing factor 3 | 0.0216819 |
| ANO6 | anoctamin 6 | 0.0216787 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0216337 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0216104 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.021571 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0213723 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0212747 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0212622 |
| SMAP1 | small ArfGAP 1 | 0.0212605 |
| BBX | bobby sox homolog (Drosophila) | 0.0211771 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0211369 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0208586 |
| MSN | moesin | 0.0208003 |
| TRIM9 | tripartite motif containing 9 | 0.0207304 |
| FAM168A | family with sequence similarity 168, member A | 0.020685 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0206207 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.020474 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0204651 |
| DIAPH1 | diaphanous-related formin 1 | 0.0201828 |
| PKN2 | protein kinase N2 | 0.02006 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0199005 |
| RPL3 | ribosomal protein L3 | 0.0196365 |
| Symbol | Name | Standardized Value |
|---|---|---|
| UBC | ubiquitin C | -0.168374 |
| TXNRD1 | thioredoxin reductase 1 | -0.102676 |
| AHNAK | AHNAK nucleoprotein | -0.101612 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.092964 |
| RPS27A | ribosomal protein S27a | -0.0765802 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.076249 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0754801 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0674565 |
| RPS8 | ribosomal protein S8 | -0.0633836 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0629677 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0601519 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0581124 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0535593 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0532855 |
| RPL23 | ribosomal protein L23 | -0.0518208 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0515586 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0514587 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0490485 |
| TMSB10 | thymosin beta 10 | -0.0487674 |
| RPL4 | ribosomal protein L4 | -0.0486676 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0481141 |
| ENO1 | enolase 1, (alpha) | -0.047167 |
| RPS3 | ribosomal protein S3 | -0.0468103 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0458103 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0452083 |
| H1-0 | H1.0 linker histone | -0.0448563 |
| OSMR | oncostatin M receptor | -0.0440796 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0432118 |
| ATF6 | activating transcription factor 6 | -0.0429797 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0427422 |
| VCL | vinculin | -0.0423671 |
| ZFR | zinc finger RNA binding protein | -0.0420584 |
| CAVIN1 | caveolae associated protein 1 | -0.0411736 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0408618 |
| RPL12 | ribosomal protein L12 | -0.0403449 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0398323 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0393252 |
| GPATCH8 | G patch domain containing 8 | -0.0385369 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0383395 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0379939 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0378028 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0374102 |
| JMJD1C | jumonji domain containing 1C | -0.0367824 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0360435 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0359553 |
| NF1 | neurofibromin 1 | -0.0353066 |
| XPO1 | exportin 1 | -0.0351208 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0344403 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0344357 |
| IGF1R | insulin-like growth factor 1 receptor | -0.034343 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0340723 |
| RPS24 | ribosomal protein S24 | -0.0339518 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0338702 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0338101 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.0337538 |
| GOLT1B | golgi transport 1B | -0.0334133 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0332866 |
| LATS2 | large tumor suppressor kinase 2 | -0.0332305 |
| CANX | calnexin | -0.0329812 |
| ADAR | adenosine deaminase, RNA-specific | -0.0327878 |
| GOLGB1 | golgin B1 | -0.0327784 |
| RBM39 | RNA binding motif protein 39 | -0.0325321 |
| RPL37 | ribosomal protein L37 | -0.0324402 |
| RPL36A | ribosomal protein L36a | -0.0323622 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0321861 |
| FAM199X | family with sequence similarity 199, X-linked | -0.0319289 |
| RPS29 | ribosomal protein S29 | -0.0315207 |
| FBXO11 | F-box protein 11 | -0.0312626 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0311426 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0310862 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0310419 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0306965 |
| WDR70 | WD repeat domain 70 | -0.0306852 |
| CALU | calumenin | -0.030205 |
| RAB10 | RAB10, member RAS oncogene family | -0.030196 |
| RHEB | Ras homolog enriched in brain | -0.0301618 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0300179 |
| CCND2 | cyclin D2 | -0.0300076 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.029781 |
| STK4 | serine/threonine kinase 4 | -0.0297582 |
| IPO7 | importin 7 | -0.0296653 |
| GLG1 | golgi glycoprotein 1 | -0.0295907 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | -0.0294705 |
| SFTPA2 | surfactant protein A2 | -0.0293975 |
| CDK12 | cyclin-dependent kinase 12 | -0.0292207 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0289955 |
| H3-3B | H3.3 histone B | -0.0289343 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0289164 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0287816 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0286612 |
| TRIM56 | tripartite motif containing 56 | -0.0286403 |
| EIF2S1 | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa | -0.0281478 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0281046 |
| FTL | ferritin, light polypeptide | -0.0280673 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0280648 |
| RPL31 | ribosomal protein L31 | -0.0277905 |
| RAB22A | RAB22A, member RAS oncogene family | -0.0276856 |
| CDK17 | cyclin-dependent kinase 17 | -0.0275183 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0274639 |
| TOP1 | topoisomerase (DNA) I | -0.0274036 |
