Regorafenib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Regorafenib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Regorafenib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 0.152213
UBC ubiquitin C 0.141659
TSC22D2 TSC22 domain family, member 2 0.13725
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.128196
IGFBP3 insulin-like growth factor binding protein 3 0.101387
FAM13A family with sequence similarity 13, member A 0.0978868
FNDC3B fibronectin type III domain containing 3B 0.0849773
TOP1 topoisomerase (DNA) I 0.0833481
BHLHE40 basic helix-loop-helix family, member e40 0.0778005
NPEPPS aminopeptidase puromycin sensitive 0.0769083
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0720437
KMT2E lysine (K)-specific methyltransferase 2E 0.0662458
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0605911
S100A6 S100 calcium binding protein A6 0.0601656
PTMA prothymosin, alpha 0.0585814
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0580595
LAMB3 laminin, beta 3 0.0562499
RPL4 ribosomal protein L4 0.0523534
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0521719
KDM5B lysine (K)-specific demethylase 5B 0.0496141
SDC4 syndecan 4 0.04848
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0484031
MXD1 MAX dimerization protein 1 0.0483594
COPA coatomer protein complex, subunit alpha 0.0472774
RNF145 ring finger protein 145 0.0461833
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0454469
PGK1 phosphoglycerate kinase 1 0.0441173
G0S2 G0/G1 switch 2 0.0439984
UBA6 ubiquitin-like modifier activating enzyme 6 0.043865
PLAU plasminogen activator, urokinase 0.0428329
GNAS GNAS complex locus 0.0424337
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0415068
CD109 CD109 molecule 0.0411637
TMEM165 transmembrane protein 165 0.039398
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0382007
MSI2 musashi RNA-binding protein 2 0.0369705
CANX calnexin 0.0368983
LIMCH1 LIM and calponin homology domains 1 0.035155
RAB1A RAB1A, member RAS oncogene family 0.0344341
STRN3 striatin, calmodulin binding protein 3 0.0330737
HILPDA hypoxia inducible lipid droplet-associated 0.0329764
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0328389
SEC23A Sec23 homolog A (S. cerevisiae) 0.032734
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0312588
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0312318
VEGFA vascular endothelial growth factor A 0.0311904
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0311085
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0303838
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0299643
TM4SF1 transmembrane 4 L six family member 1 0.0297171
BASP1 brain abundant, membrane attached signal protein 1 0.0296364
OGA O-GlcNAcase 0.0289286
FOSL1 FOS-like antigen 1 0.0288911
GARS1 glycyl-tRNA synthetase 1 0.0287354
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0286701
FAM162A family with sequence similarity 162, member A 0.0286282
AHNAK AHNAK nucleoprotein 0.0282354
QKI QKI, KH domain containing, RNA binding 0.0274425
SAMD4A sterile alpha motif domain containing 4A 0.0274311
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0271374
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0270218
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0267064
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0262307
ADAM9 ADAM metallopeptidase domain 9 0.0256526
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.025573
WASF2 WAS protein family, member 2 0.0252456
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0247359
SOX4 SRY (sex determining region Y)-box 4 0.024444
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0243824
FAM168A family with sequence similarity 168, member A 0.0242034
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0241952
CERT1 ceramide transporter 1 0.024015
F3 coagulation factor III (thromboplastin, tissue factor) 0.0239668
USP3 ubiquitin specific peptidase 3 0.0239026
RNASE3 ribonuclease, RNase A family, 3 0.0237848
PRRC1 proline-rich coiled-coil 1 0.0237783
CALR calreticulin 0.0237213
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0237087
RAD21 RAD21 homolog (S. pombe) 0.0236216
TMEM263 transmembrane protein 263 0.0234711
CD2AP CD2-associated protein 0.0233976
IRF6 interferon regulatory factor 6 0.0232079
PDIA4 protein disulfide isomerase family A, member 4 0.0231747
WAC WW domain containing adaptor with coiled-coil 0.0225448
ANKRD11 ankyrin repeat domain 11 0.0224468
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0222663
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0219678
TFG TRK-fused gene 0.0219095
ATOSA atos homolog A 0.0217615
ENO1 enolase 1, (alpha) 0.0212824
HLA-A major histocompatibility complex, class I, A 0.0211902
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0208552
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0208008
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0206611
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0206462
PUM1 pumilio RNA-binding family member 1 0.0204125
PTPRJ protein tyrosine phosphatase, receptor type, J 0.020314
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0202247
LMAN1 lectin, mannose-binding, 1 0.0201307
SACK1A scaffolding CK1 anchoring protein A 0.0199624

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.273745
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.143042
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.125446
LAMC2 laminin, gamma 2 -0.104165
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0801568
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0798217
HSPA8 heat shock 70kDa protein 8 -0.0775981
TXNRD1 thioredoxin reductase 1 -0.0773049
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0742901
ASPH aspartate beta-hydroxylase -0.0672207
EXT1 exostosin glycosyltransferase 1 -0.0648603
NDRG1 N-myc downstream regulated 1 -0.0592604
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0591333
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0581361
TPT1 tumor protein, translationally-controlled 1 -0.0574342
MYH9 myosin, heavy chain 9, non-muscle -0.0541126
DSPP dentin sialophosphoprotein -0.0517673
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0506061
RPL7 ribosomal protein L7 -0.0504129
NAMPT nicotinamide phosphoribosyltransferase -0.0487259
STAT1 signal transducer and activator of transcription 1, 91kDa -0.047355
RPS2 ribosomal protein S2 -0.0470588
DSG2 desmoglein 2 -0.0448706
ELL2 elongation factor, RNA polymerase II, 2 -0.0442586
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0416902
MKI67 marker of proliferation Ki-67 -0.0386813
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0386798
FBXO32 F-box protein 32 -0.037926
RPLP2 ribosomal protein, large, P2 -0.0366978
CD44 CD44 molecule (Indian blood group) -0.0365943
POTEF POTE ankyrin domain family, member F -0.0362137
RPL11 ribosomal protein L11 -0.0355731
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.035055
CLTC clathrin, heavy chain (Hc) -0.0349099
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0345672
EIF1 eukaryotic translation initiation factor 1 -0.0342342
SGMS2 sphingomyelin synthase 2 -0.0340509
NAV2 neuron navigator 2 -0.0333884
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0333705
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0332747
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.033032
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.032376
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0319985
MSN moesin -0.031179
FHIT fragile histidine triad -0.0309849
GOLGA4 golgin A4 -0.0309841
HMGB2 high mobility group box 2 -0.0309696
TUBB4B tubulin, beta 4B class IVb -0.0306615
BRD2 bromodomain containing 2 -0.0304766
MBNL1 muscleblind-like splicing regulator 1 -0.0304402
SFPQ splicing factor proline/glutamine-rich -0.0304234
PRRC2C proline-rich coiled-coil 2C -0.0300626
RPL38 ribosomal protein L38 -0.0298738
RPL37A ribosomal protein L37a -0.0293332
EGFR epidermal growth factor receptor -0.0290135
TJP1 tight junction protein 1 -0.0285386
ARHGAP5 Rho GTPase activating protein 5 -0.0285364
ANO6 anoctamin 6 -0.0284594
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0280977
RPL9 ribosomal protein L9 -0.0277752
RPL12 ribosomal protein L12 -0.0276723
VMP1 vacuole membrane protein 1 -0.0276223
MACC1 metastasis associated in colon cancer 1 -0.0273093
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0271983
DST dystonin -0.0270948
RPL3 ribosomal protein L3 -0.027024
MYO5B myosin VB -0.0269079
RPS3 ribosomal protein S3 -0.0265667
OSMR oncostatin M receptor -0.0264267
IL6ST interleukin 6 signal transducer -0.0261664
PLEC plectin -0.0261203
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0258803
DTNA dystrobrevin, alpha -0.0258205
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides -0.0257416
CAPN2 calpain 2, (m/II) large subunit -0.0256596
RPS29 ribosomal protein S29 -0.0255502
SVIL supervillin -0.0253962
ADAR adenosine deaminase, RNA-specific -0.0253116
TXNIP thioredoxin interacting protein -0.0251497
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0250061
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0247726
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0247628
ANXA1 annexin A1 -0.0244386
SAMD12 sterile alpha motif domain containing 12 -0.0243749
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0241898
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0241077
CSNK1A1 casein kinase 1, alpha 1 -0.0241056
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0239791
PLSCR1 phospholipid scramblase 1 -0.0239755
RPL15 ribosomal protein L15 -0.0239088
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0237471
EZR ezrin -0.0234099
TRIO trio Rho guanine nucleotide exchange factor -0.0233924
TACSTD2 tumor-associated calcium signal transducer 2 -0.0233055
PAPOLA poly(A) polymerase alpha -0.0232137
VGLL3 vestigial-like family member 3 -0.0228336
CCNB1 cyclin B1 -0.0227421
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.0227051
SFTPA2 surfactant protein A2 -0.0226083
ATXN1 ataxin 1 -0.0224867