Regorafenib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Regorafenib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Regorafenib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.102074
EFNA5 ephrin-A5 0.081496
PCBP3 poly(rC) binding protein 3 0.0694717
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0561456
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.055458
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0543764
PTMA prothymosin, alpha 0.0522575
NRCAM neuronal cell adhesion molecule 0.0521483
PTGR1 prostaglandin reductase 1 0.0513062
NAMPT nicotinamide phosphoribosyltransferase 0.0507174
FAM13A family with sequence similarity 13, member A 0.0492518
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0477851
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0442612
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0404645
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0391263
TMX4 thioredoxin-related transmembrane protein 4 0.0388923
OGA O-GlcNAcase 0.037688
KMT2E lysine (K)-specific methyltransferase 2E 0.0353842
IGFBP3 insulin-like growth factor binding protein 3 0.0353403
PYGL phosphorylase, glycogen, liver 0.0342651
LIMCH1 LIM and calponin homology domains 1 0.0341193
TGFBI transforming growth factor, beta-induced, 68kDa 0.0336903
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0327589
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0325087
COL5A2 collagen, type V, alpha 2 0.0324475
CENPF centromere protein F, 350/400kDa 0.0310638
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0306899
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0305294
DGKD diacylglycerol kinase, delta 130kDa 0.029407
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0289518
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0285326
ESYT2 extended synaptotagmin-like protein 2 0.0283401
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0264122
PNISR PNN-interacting serine/arginine-rich protein 0.0243032
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0242616
COL4A5 collagen, type IV, alpha 5 0.0238555
PDE10A phosphodiesterase 10A 0.023786
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0234399
RPL4 ribosomal protein L4 0.0228988
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.0228248
CHD1L chromodomain helicase DNA binding protein 1-like 0.0226588
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.022606
DDIT4 DNA-damage-inducible transcript 4 0.0220193
TNIP1 TNFAIP3 interacting protein 1 0.0218096
DYNC2I1 dynein 2 intermediate chain 1 0.0214128
TPM3 tropomyosin 3 0.0210133
MFF mitochondrial fission factor 0.0209895
AGFG1 ArfGAP with FG repeats 1 0.0209666
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0208887
SET SET nuclear proto-oncogene 0.0205444
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0200102
MKI67 marker of proliferation Ki-67 0.0198921
SLC16A6 solute carrier family 16, member 6 0.0196272
ZNF292 zinc finger protein 292 0.0192533
SLF1 SMC5-SMC6 complex localization factor 1 0.0192442
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0185379
GPRIN3 GPRIN family member 3 0.0181
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0180351
PGK1 phosphoglycerate kinase 1 0.0178649
ANKRD36 ankyrin repeat domain 36 0.0178113
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0174532
NFE2L1 nuclear factor, erythroid 2-like 1 0.0174316
BHLHE40 basic helix-loop-helix family, member e40 0.0173403
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.0171854
ANKRD12 ankyrin repeat domain 12 0.017124
INSIG2 insulin induced gene 2 0.0171008
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0170025
BRWD3 bromodomain and WD repeat domain containing 3 0.0169737
NGLY1 N-glycanase 1 0.0169573
PHF21A PHD finger protein 21A 0.0168706
MYOF myoferlin 0.0168232
RNF24 ring finger protein 24 0.0168182
BCAS3 breast carcinoma amplified sequence 3 0.016578
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0165757
WDFY2 WD repeat and FYVE domain containing 2 0.0165207
HDGF hepatoma-derived growth factor 0.0165178
AVL9 AVL9 homolog (S. cerevisiase) 0.0164793
KTN1 kinectin 1 (kinesin receptor) 0.0160738
MAP2K1 mitogen-activated protein kinase kinase 1 0.0160018
CTNND2 catenin (cadherin-associated protein), delta 2 0.0159504
CDCP1 CUB domain containing protein 1 0.0159359
YEATS2 YEATS domain containing 2 0.0159109
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0157265
METTL15 methyltransferase like 15 0.0156395
BCLAF1 BCL2-associated transcription factor 1 0.0155523
WARS1 tryptophanyl-tRNA synthetase 1 0.0155384
GREM2 gremlin 2, DAN family BMP antagonist 0.01539
S100A6 S100 calcium binding protein A6 0.0152802
ZMYND8 zinc finger, MYND-type containing 8 0.0152446
ANKRD11 ankyrin repeat domain 11 0.0152296
PDPK1 3-phosphoinositide dependent protein kinase 1 0.015166
NEMF nuclear export mediator factor 0.0151091
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0150305
PDGFA platelet-derived growth factor alpha polypeptide 0.0149941
MLKL mixed lineage kinase domain-like 0.0149525
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0149165
RAI1 retinoic acid induced 1 0.0148225
SBF2 SET binding factor 2 0.0145342
RNF145 ring finger protein 145 0.0144987
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0143914

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.355615
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.218696
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.193656
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.150618
FN1 fibronectin 1 -0.117451
TPT1 tumor protein, translationally-controlled 1 -0.107263
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.104745
FTL ferritin, light polypeptide -0.0906683
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0742074
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0738961
CDH13 cadherin 13 -0.0670216
VCL vinculin -0.0634744
TXNRD1 thioredoxin reductase 1 -0.0633313
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0610559
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0603763
FTH1 ferritin, heavy polypeptide 1 -0.0601055
TMSB10 thymosin beta 10 -0.0595224
FMNL2 formin-like 2 -0.056965
EIF1 eukaryotic translation initiation factor 1 -0.0555547
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0534876
VIM vimentin -0.0527715
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0527385
EXT1 exostosin glycosyltransferase 1 -0.0522435
LDHA lactate dehydrogenase A -0.0520332
JMJD1C jumonji domain containing 1C -0.0517414
AKAP13 A kinase (PRKA) anchor protein 13 -0.0515203
RPL31 ribosomal protein L31 -0.0502375
PM20D1 peptidase M20 domain containing 1 -0.0499196
DOCK4 dedicator of cytokinesis 4 -0.0496768
SMAD2 SMAD family member 2 -0.0492292
FNDC3A fibronectin type III domain containing 3A -0.0489528
SLC38A2 solute carrier family 38, member 2 -0.0470433
EZR ezrin -0.0449071
COL8A1 collagen, type VIII, alpha 1 -0.0449
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0439117
RPLP0 ribosomal protein, large, P0 -0.0429814
DST dystonin -0.042495
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0423412
RPS24 ribosomal protein S24 -0.0423038
PDIA3 protein disulfide isomerase family A, member 3 -0.0411548
RPL12 ribosomal protein L12 -0.0403382
BASP1 brain abundant, membrane attached signal protein 1 -0.0396738
INTS6 integrator complex subunit 6 -0.0390499
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0387758
RAB7A RAB7A, member RAS oncogene family -0.0386349
TM4SF1 transmembrane 4 L six family member 1 -0.0383047
MAP1B microtubule-associated protein 1B -0.0379883
CD44 CD44 molecule (Indian blood group) -0.0379567
ANXA2 annexin A2 -0.0374833
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0369117
PDLIM5 PDZ and LIM domain 5 -0.0366884
IARS1 isoleucyl-tRNA synthetase 1 -0.0364137
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0363551
TGFBR1 transforming growth factor, beta receptor 1 -0.0354799
KYNU kynureninase -0.0352866
TNPO1 transportin 1 -0.034953
ELL2 elongation factor, RNA polymerase II, 2 -0.0346935
RACK1 receptor for activated C kinase 1 -0.0346876
SH3KBP1 SH3-domain kinase binding protein 1 -0.0345941
LOC112694756 uncharaterized LOC112694756 -0.0344119
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0340123
AGTPBP1 ATP/GTP binding protein 1 -0.0325126
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0324923
SFTPA2 surfactant protein A2 -0.0324538
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0322664
RPS23 ribosomal protein S23 -0.0317969
RPL7A ribosomal protein L7a -0.0313182
SMOC1 SPARC related modular calcium binding 1 -0.0311723
CREB5 cAMP responsive element binding protein 5 -0.0311203
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0305249
MORF4L2 mortality factor 4 like 2 -0.0302882
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0302068
RPS14 ribosomal protein S14 -0.0296307
RPL7 ribosomal protein L7 -0.0294783
PPIA peptidylprolyl isomerase A (cyclophilin A) -0.029446
RPL23 ribosomal protein L23 -0.0294296
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0294009
OXSR1 oxidative stress responsive 1 -0.0293359
NT5C2 5'-nucleotidase, cytosolic II -0.0293077
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0292723
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0290991
POTEF POTE ankyrin domain family, member F -0.0289533
COPA coatomer protein complex, subunit alpha -0.0286857
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0286673
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0285684
HDLBP high density lipoprotein binding protein -0.0285474
RPLP1 ribosomal protein, large, P1 -0.0281535
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0280351
RPS25 ribosomal protein S25 -0.0278806
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0273911
SQSTM1 sequestosome 1 -0.0269202
EGR1 early growth response 1 -0.0268661
MAP7 microtubule-associated protein 7 -0.0265802
ZEB2 zinc finger E-box binding homeobox 2 -0.0265625
GLRX glutaredoxin (thioltransferase) -0.0264723
PRRC2C proline-rich coiled-coil 2C -0.0263872
ANXA1 annexin A1 -0.0261821
USP53 ubiquitin specific peptidase 53 -0.0258003
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0255583
RPL28 ribosomal protein L28 -0.0255064