| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Regorafenib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Regorafenib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.210163 |
| RTN4 | reticulon 4 | 0.138172 |
| SPAG9 | sperm associated antigen 9 | 0.135295 |
| GPC6 | glypican 6 | 0.131785 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.124145 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.112636 |
| APP | amyloid beta (A4) precursor protein | 0.111757 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.111604 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.107848 |
| FTL | ferritin, light polypeptide | 0.105141 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.104679 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.102194 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0927211 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0897126 |
| RUNX1 | runt-related transcription factor 1 | 0.0867567 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0846425 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0819054 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0807022 |
| TFG | TRK-fused gene | 0.0791336 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.077264 |
| INHBA | inhibin, beta A | 0.0758222 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0748578 |
| GNAS | GNAS complex locus | 0.0737097 |
| NBAS | neuroblastoma amplified sequence | 0.0735847 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0707625 |
| CANX | calnexin | 0.0701659 |
| COPA | coatomer protein complex, subunit alpha | 0.0665452 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0662699 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0647083 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0629075 |
| SMAD3 | SMAD family member 3 | 0.0615577 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0593543 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0588191 |
| SLMAP | sarcolemma associated protein | 0.0586311 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0579396 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.057543 |
| ZNF292 | zinc finger protein 292 | 0.0567748 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.05676 |
| FMN1 | formin 1 | 0.0531332 |
| FAM13A | family with sequence similarity 13, member A | 0.051245 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0506356 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0506163 |
| PTK2 | protein tyrosine kinase 2 | 0.0503023 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0494602 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0490105 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0482421 |
| JMJD1C | jumonji domain containing 1C | 0.0481809 |
| CTBP2 | C-terminal binding protein 2 | 0.0477092 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0476006 |
| RPL35 | ribosomal protein L35 | 0.0474034 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0466482 |
| RPL19 | ribosomal protein L19 | 0.0461957 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0459434 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0456989 |
| RAD51B | RAD51 paralog B | 0.0449027 |
| STK24 | serine/threonine kinase 24 | 0.0439886 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0432667 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0426162 |
| MATR3 | matrin 3 | 0.0425122 |
| CDH13 | cadherin 13 | 0.0424283 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0417178 |
| VMP1 | vacuole membrane protein 1 | 0.0415622 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0411538 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0401633 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0398459 |
| NAV2 | neuron navigator 2 | 0.0393056 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0391758 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0374993 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0374381 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0369107 |
| RPL35A | ribosomal protein L35a | 0.0364229 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0361045 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0359972 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.035377 |
| CTTN | cortactin | 0.0349195 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0346895 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0335806 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0335719 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0334285 |
| DIAPH2 | diaphanous-related formin 2 | 0.0318037 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0303057 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.029485 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0289558 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0284669 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0284436 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0277278 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0269983 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0268172 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0263547 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0254545 |
| PTAR1 | protein prenyltransferase alpha subunit repeat containing 1 | 0.0252876 |
| ZNF148 | zinc finger protein 148 | 0.0251928 |
| THOC2 | THO complex 2 | 0.0250388 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0246913 |
| MSI2 | musashi RNA-binding protein 2 | 0.0245443 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0243332 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.023537 |
| DTNA | dystrobrevin, alpha | 0.0223871 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0218386 |
| FRMD4A | FERM domain containing 4A | 0.0214951 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.130235 |
| FN1 | fibronectin 1 | -0.129937 |
| VIM | vimentin | -0.110325 |
| FOXP1 | forkhead box P1 | -0.0984226 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0963405 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0915493 |
| OSMR | oncostatin M receptor | -0.0901638 |
| EGFR | epidermal growth factor receptor | -0.0888924 |
| ANXA2 | annexin A2 | -0.08855 |
| CD44 | CD44 molecule (Indian blood group) | -0.0844755 |
| PDE10A | phosphodiesterase 10A | -0.0834671 |
| RPS6 | ribosomal protein S6 | -0.0808564 |
| HMGA2 | high mobility group AT-hook 2 | -0.0780042 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0772869 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0752762 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0746696 |
| AHNAK | AHNAK nucleoprotein | -0.0733968 |
| PRKCA | protein kinase C, alpha | -0.0726347 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0721392 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0698355 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0664097 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0658796 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0650185 |
| NF1 | neurofibromin 1 | -0.0649686 |
| RPLP1 | ribosomal protein, large, P1 | -0.063982 |
| LMO7 | LIM domain 7 | -0.0636105 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.062505 |
| ATXN1 | ataxin 1 | -0.0621122 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0617337 |
| RPS8 | ribosomal protein S8 | -0.0608585 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0608421 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0602402 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0594687 |
| PRELID2 | PRELI domain containing 2 | -0.0585829 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0580215 |
| ITGA6 | integrin, alpha 6 | -0.0574745 |
| INTS6 | integrator complex subunit 6 | -0.0571184 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.05701 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0556914 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0546477 |
| TXNRD1 | thioredoxin reductase 1 | -0.0546093 |
| SP100 | SP100 nuclear antigen | -0.0525572 |
| FLNB | filamin B, beta | -0.0523509 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0522886 |
| CNKSR3 | CNKSR family member 3 | -0.052197 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0516887 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0513106 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0510725 |
| FMNL2 | formin-like 2 | -0.0507815 |
| MCL1 | myeloid cell leukemia 1 | -0.0507811 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.048853 |
| CDCP1 | CUB domain containing protein 1 | -0.0479966 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0473096 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0472619 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0463294 |
| NAV1 | neuron navigator 1 | -0.044785 |
| UBC | ubiquitin C | -0.0443201 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.044193 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0441063 |
| PRSS23 | protease, serine, 23 | -0.0439973 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0436595 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0429908 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0429211 |
| TPM4 | tropomyosin 4 | -0.0409598 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.040505 |
| RPL37A | ribosomal protein L37a | -0.0400394 |
| EFNA5 | ephrin-A5 | -0.0399524 |
| MYOF | myoferlin | -0.0393263 |
| FAM107B | family with sequence similarity 107, member B | -0.0386104 |
| RPLP2 | ribosomal protein, large, P2 | -0.0385594 |
| RACK1 | receptor for activated C kinase 1 | -0.0383876 |
| RPL34 | ribosomal protein L34 | -0.0381301 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0379355 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0378712 |
| PTMA | prothymosin, alpha | -0.0374442 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0361206 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0352389 |
| GANAB | glucosidase, alpha; neutral AB | -0.0350912 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0346503 |
| LAMB3 | laminin, beta 3 | -0.034516 |
| TAF1B | TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa | -0.034483 |
| LOXL2 | lysyl oxidase-like 2 | -0.0341512 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0341141 |
| SLTM | SAFB-like, transcription modulator | -0.0341029 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.0323252 |
| ATP11A | ATPase, class VI, type 11A | -0.0322432 |
| ENO1 | enolase 1, (alpha) | -0.0317 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0309661 |
| CCNI | cyclin I | -0.030953 |
| RPS25 | ribosomal protein S25 | -0.030937 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | -0.0304126 |
| SETD5 | SET domain containing 5 | -0.0301045 |
| IGF2 | insulin-like growth factor 2 | -0.0300703 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0293992 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0292319 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0288123 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0287578 |
| RPL11 | ribosomal protein L11 | -0.0287351 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0279868 |
| S100A6 | S100 calcium binding protein A6 | -0.0276315 |
