| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Regorafenib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Regorafenib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.128893 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0959651 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0883086 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.084825 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0846777 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0660676 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0650484 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0637382 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0586429 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.056725 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.05563 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0542192 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0526921 |
| COL3A1 | collagen, type III, alpha 1 | 0.0524006 |
| PTMA | prothymosin, alpha | 0.051303 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0511267 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0510976 |
| FIP1L1 | factor interacting with PAPOLA and CPSF1 | 0.0487302 |
| NUP58 | nucleoporin 58 | 0.0486354 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0482915 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0481413 |
| MKI67 | marker of proliferation Ki-67 | 0.0476283 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0461113 |
| WDR43 | WD repeat domain 43 | 0.0433018 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0431776 |
| ITGAV | integrin, alpha V | 0.0428167 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0420197 |
| ANXA1 | annexin A1 | 0.0417024 |
| FOXG1 | forkhead box G1 | 0.0416053 |
| FMNL2 | formin-like 2 | 0.0415363 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | 0.0410649 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.039947 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0381889 |
| SPAG9 | sperm associated antigen 9 | 0.0381635 |
| H1-4 | H1.4 linker histone, cluster member | 0.0375903 |
| SARNP | SAP domain containing ribonucleoprotein | 0.0372172 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0371603 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0369559 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0367498 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0365312 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0364622 |
| COPA | coatomer protein complex, subunit alpha | 0.0363683 |
| H2AZ2 | H2A.Z variant histone 2 | 0.0362781 |
| DST | dystonin | 0.0361787 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0359006 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0357348 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0354359 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0349784 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0347639 |
| RYBP | RING1 and YY1 binding protein | 0.0345786 |
| ZNF292 | zinc finger protein 292 | 0.0344182 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0343942 |
| MB21D2 | Mab-21 domain containing 2 | 0.0339478 |
| QKI | QKI, KH domain containing, RNA binding | 0.0337411 |
| RPL21 | ribosomal protein L21 | 0.033741 |
| CLU | clusterin | 0.0336252 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0330973 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0329651 |
| SP3 | Sp3 transcription factor | 0.0322994 |
| COL5A2 | collagen, type V, alpha 2 | 0.0321756 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0321574 |
| THOC2 | THO complex 2 | 0.032062 |
| RO60 | Ro60, Y RNA binding protein | 0.0319501 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0319309 |
| SCAF4 | SR-related CTD-associated factor 4 | 0.0319108 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.0318686 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0316695 |
| FNDC3B | fibronectin type III domain containing 3B | 0.03097 |
| LDHA | lactate dehydrogenase A | 0.0308447 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0308264 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0307303 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0306575 |
| RBM33 | RNA binding motif protein 33 | 0.0305876 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0305837 |
| PNN | pinin, desmosome associated protein | 0.0304357 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.030118 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0300716 |
| XPO4 | exportin 4 | 0.0298916 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0296598 |
| ZNF451 | zinc finger protein 451 | 0.0296349 |
| EMP1 | epithelial membrane protein 1 | 0.0294327 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.029354 |
| CYTH3 | cytohesin 3 | 0.0293331 |
| MCM3 | minichromosome maintenance complex component 3 | 0.0290636 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0289868 |
| FYTTD1 | forty-two-three domain containing 1 | 0.0287681 |
| RBM39 | RNA binding motif protein 39 | 0.0286962 |
| THBS1 | thrombospondin 1 | 0.028684 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0284692 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0284048 |
| PGPEP1L | pyroglutamyl-peptidase I-like | 0.0283477 |
| HBS1L | HBS1-like translational GTPase | 0.0283057 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0282724 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.0282149 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0282001 |
| USP53 | ubiquitin specific peptidase 53 | 0.0281464 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0281426 |
| CCDC88A | coiled-coil domain containing 88A | 0.0279764 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0277569 |
| MDN1 | MDN1, midasin homolog (yeast) | 0.027711 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.141812 |
| FOXP2 | forkhead box P2 | -0.0821174 |
| VIM | vimentin | -0.0813071 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0810019 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0714189 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.068908 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0625281 |
| RPS6 | ribosomal protein S6 | -0.0615732 |
| CADM2 | cell adhesion molecule 2 | -0.0615424 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0586136 |
| FN1 | fibronectin 1 | -0.0583615 |
| SYT1 | synaptotagmin I | -0.0575223 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0559729 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0558675 |
| FTL | ferritin, light polypeptide | -0.0547775 |
| TXNRD1 | thioredoxin reductase 1 | -0.0542839 |
| TENM3 | teneurin transmembrane protein 3 | -0.0533099 |
| ACTG1 | actin gamma 1 | -0.0510121 |
| RPL35A | ribosomal protein L35a | -0.0504212 |
| ENO1 | enolase 1, (alpha) | -0.0502065 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.050071 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0500021 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.049662 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0496514 |
| TPX2 | TPX2, microtubule-associated | -0.0490854 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0470003 |
| POTEF | POTE ankyrin domain family, member F | -0.0468044 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0448128 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0441666 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0422975 |
| BBX | bobby sox homolog (Drosophila) | -0.0422146 |
| RPS16 | ribosomal protein S16 | -0.0421932 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.041071 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0409175 |
| TMSB10 | thymosin beta 10 | -0.0408692 |
| AHNAK | AHNAK nucleoprotein | -0.0398132 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0395144 |
| ECT2 | epithelial cell transforming 2 | -0.038879 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0387887 |
| BPTF | bromodomain PHD finger transcription factor | -0.0386312 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0380543 |
| RPL23 | ribosomal protein L23 | -0.0378962 |
| RPLP1 | ribosomal protein, large, P1 | -0.0373795 |
| PGK1 | phosphoglycerate kinase 1 | -0.0373669 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0369853 |
| RTN4 | reticulon 4 | -0.036708 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0362087 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0360143 |
| GRB2 | growth factor receptor-bound protein 2 | -0.0360041 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0356992 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0355355 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.035094 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0350027 |
| RSF1 | remodeling and spacing factor 1 | -0.0349751 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.034851 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0347098 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0344205 |
| SNX6 | sorting nexin 6 | -0.0339818 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.033439 |
| TUBA1B | tubulin, alpha 1b | -0.033402 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0331374 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0330416 |
| FIGN | fidgetin | -0.0327912 |
| RACK1 | receptor for activated C kinase 1 | -0.0322237 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0321873 |
| RPS19 | ribosomal protein S19 | -0.0320929 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.031988 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0319647 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0318614 |
| MAP1B | microtubule-associated protein 1B | -0.0317979 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0317555 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.031755 |
| PPP4R2 | protein phosphatase 4, regulatory subunit 2 | -0.0311442 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -0.0310009 |
| TCF12 | transcription factor 12 | -0.0308151 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0307177 |
| USP1 | ubiquitin specific peptidase 1 | -0.0303757 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0302481 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0301041 |
| RBBP4 | retinoblastoma binding protein 4 | -0.0300292 |
| AK1 | adenylate kinase 1 | -0.0298297 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0296602 |
| WDR45B | WD repeat domain 45B | -0.0296574 |
| HMGA1 | high mobility group AT-hook 1 | -0.0294807 |
| SIK2 | salt-inducible kinase 2 | -0.0294655 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0292812 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0291592 |
| GPC3 | glypican 3 | -0.0290452 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0285959 |
| LATS2 | large tumor suppressor kinase 2 | -0.0285733 |
| RPL30 | ribosomal protein L30 | -0.0285561 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0284126 |
| ZNF644 | zinc finger protein 644 | -0.0284045 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0283948 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0283929 |
| RNF13 | ring finger protein 13 | -0.0283651 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0281894 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.028075 |
| IGF2BP1 | insulin-like growth factor 2 mRNA binding protein 1 | -0.0280501 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0280333 |
