Regorafenib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Regorafenib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Regorafenib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZFAND3 zinc finger, AN1-type domain 3 0.0523522
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0520997
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.050647
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0475501
EXT1 exostosin glycosyltransferase 1 0.0433006
FLNB filamin B, beta 0.0430412
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0422143
ADAM10 ADAM metallopeptidase domain 10 0.0387466
CAMTA1 calmodulin binding transcription activator 1 0.0383144
RBM39 RNA binding motif protein 39 0.0382537
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0378527
NBAS neuroblastoma amplified sequence 0.0354787
BIRC6 baculoviral IAP repeat containing 6 0.0351899
PICALM phosphatidylinositol binding clathrin assembly protein 0.03338
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0333771
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0326588
PTK2 protein tyrosine kinase 2 0.0312271
PRELID2 PRELI domain containing 2 0.0311329
KMT2E lysine (K)-specific methyltransferase 2E 0.0302318
DSCAM Down syndrome cell adhesion molecule 0.0298846
KDM4C lysine (K)-specific demethylase 4C 0.0294579
DENND4A DENN/MADD domain containing 4A 0.0293731
ZBTB20 zinc finger and BTB domain containing 20 0.0293729
MED13L mediator complex subunit 13-like 0.0291438
ZNF292 zinc finger protein 292 0.0288419
ZCCHC7 zinc finger, CCHC domain containing 7 0.0286952
SMYD3 SET and MYND domain containing 3 0.0283062
FBXO11 F-box protein 11 0.028249
PTPRG protein tyrosine phosphatase, receptor type, G 0.0282482
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0279903
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0279385
ANK2 ankyrin 2, neuronal 0.0273651
MED13 mediator complex subunit 13 0.0272201
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0269736
NUP58 nucleoporin 58 0.0269105
GOLGA4 golgin A4 0.0263016
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0262771
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0261562
TNRC6B trinucleotide repeat containing 6B 0.0259062
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0256676
FNDC3B fibronectin type III domain containing 3B 0.0256162
ANKRD36 ankyrin repeat domain 36 0.0255175
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.025146
KDM6A lysine (K)-specific demethylase 6A 0.0250536
GSK3B glycogen synthase kinase 3 beta 0.0243771
ELOVL5 ELOVL fatty acid elongase 5 0.0242669
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0237593
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0235053
USP34 ubiquitin specific peptidase 34 0.0235046
KMT2C lysine (K)-specific methyltransferase 2C 0.0233897
UBA6 ubiquitin-like modifier activating enzyme 6 0.0233198
YEATS2 YEATS domain containing 2 0.0232673
MBD5 methyl-CpG binding domain protein 5 0.0230516
ITCH itchy E3 ubiquitin protein ligase 0.022921
RHBDD1 rhomboid domain containing 1 0.0229054
METTL15 methyltransferase like 15 0.0226938
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.022431
TBC1D22A TBC1 domain family, member 22A 0.0222548
INTS6 integrator complex subunit 6 0.0221839
VMP1 vacuole membrane protein 1 0.0220786
CCNL1 cyclin L1 0.0219787
YAP1 Yes-associated protein 1 0.0218351
AKAP9 A kinase (PRKA) anchor protein 9 0.0217859
HM13 histocompatibility (minor) 13 0.0217176
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0215709
WDR43 WD repeat domain 43 0.021549
NAMPT nicotinamide phosphoribosyltransferase 0.0214167
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.021383
VEGFA vascular endothelial growth factor A 0.0212841
N4BP2L2 NEDD4 binding protein 2-like 2 0.021257
SEC31A SEC31 homolog A (S. cerevisiae) 0.0211213
NCEH1 neutral cholesterol ester hydrolase 1 0.0209336
TTC3 tetratricopeptide repeat domain 3 0.0207722
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.020726
FAM168A family with sequence similarity 168, member A 0.0206575
FOXJ3 forkhead box J3 0.0204002
KDM3A lysine (K)-specific demethylase 3A 0.0203157
SPPL3 signal peptide peptidase like 3 0.0202383
PCNX1 pecanex 1 0.0200653
SRP54 signal recognition particle 54kDa 0.0200122
PCBP2 poly(rC) binding protein 2 0.019946
STRN3 striatin, calmodulin binding protein 3 0.0199454
GLS2 glutaminase 2 (liver, mitochondrial) 0.0198939
RUSC2 RUN and SH3 domain containing 2 0.0198794
SBF2 SET binding factor 2 0.0197209
NCKAP1 NCK-associated protein 1 0.0197084
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.019629
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0195755
RBM33 RNA binding motif protein 33 0.0195263
RBM6 RNA binding motif protein 6 0.019453
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0194425
BMP2K BMP2 inducible kinase 0.0193355
CUL3 cullin 3 0.0192598
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0189431
GOSR2 golgi SNAP receptor complex member 2 0.0189321
HELZ helicase with zinc finger 0.0189312
NBEAL1 neurobeachin-like 1 0.0188477
FUBP1 far upstream element (FUSE) binding protein 1 0.0187212
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0185844
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0185097

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.262945
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.214118
TPT1 tumor protein, translationally-controlled 1 -0.174712
RPS6 ribosomal protein S6 -0.121329
RPS8 ribosomal protein S8 -0.100993
ACTG1 actin gamma 1 -0.0948289
RPLP1 ribosomal protein, large, P1 -0.0852527
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0833111
RPL35A ribosomal protein L35a -0.0823475
VCL vinculin -0.0820491
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0817376
RPL12 ribosomal protein L12 -0.0804272
RPL34 ribosomal protein L34 -0.0800515
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.077607
NAP1L1 nucleosome assembly protein 1-like 1 -0.0766496
AHNAK AHNAK nucleoprotein -0.0755717
RPLP0 ribosomal protein, large, P0 -0.0745847
BMP10 bone morphogenetic protein 10 -0.0703021
HSPB1 heat shock 27kDa protein 1 -0.0700335
RPLP2 ribosomal protein, large, P2 -0.0656511
RPL26 ribosomal protein L26 -0.0647816
S100A4 S100 calcium binding protein A4 -0.0597967
RPL19 ribosomal protein L19 -0.0573474
RPS24 ribosomal protein S24 -0.0568415
MKI67 marker of proliferation Ki-67 -0.0547318
S100A6 S100 calcium binding protein A6 -0.0530913
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0530485
TMSB4X thymosin beta 4, X-linked -0.0525867
CCND1 cyclin D1 -0.0523322
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0518347
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0514337
RPS23 ribosomal protein S23 -0.0503938
RPS13 ribosomal protein S13 -0.0497948
RPS21 ribosomal protein S21 -0.0494086
RPL11 ribosomal protein L11 -0.0489886
KPNB1 karyopherin (importin) beta 1 -0.0473693
RPL23 ribosomal protein L23 -0.046492
RPL13A ribosomal protein L13a -0.0464187
RPS19 ribosomal protein S19 -0.0455747
RPL9 ribosomal protein L9 -0.0451812
RPL36 ribosomal protein L36 -0.045049
ENO1 enolase 1, (alpha) -0.0445351
RPL32 ribosomal protein L32 -0.0435581
RPL37A ribosomal protein L37a -0.0416713
RSL1D1 ribosomal L1 domain containing 1 -0.0412569
RPL7A ribosomal protein L7a -0.0399928
RPS3 ribosomal protein S3 -0.0393591
MYL12B myosin, light chain 12B, regulatory -0.0391525
RPL31 ribosomal protein L31 -0.0390859
TPI1 triosephosphate isomerase 1 -0.0373263
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0369627
EIF1 eukaryotic translation initiation factor 1 -0.0365809
RPS12 ribosomal protein S12 -0.0364875
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0361924
TM4SF1 transmembrane 4 L six family member 1 -0.036182
RACK1 receptor for activated C kinase 1 -0.0358638
RPL28 ribosomal protein L28 -0.0355758
NBEA neurobeachin -0.0354518
RPS25 ribosomal protein S25 -0.035411
RPL18 ribosomal protein L18 -0.0349753
RPS27A ribosomal protein S27a -0.0344297
ARL4C ADP-ribosylation factor-like 4C -0.0344207
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0343939
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0342948
RPS17 ribosomal protein S17 -0.0342161
RPL27A ribosomal protein L27a -0.0340941
SMC4 structural maintenance of chromosomes 4 -0.0336866
RPS11 ribosomal protein S11 -0.0336539
RPL8 ribosomal protein L8 -0.0332817
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0327206
RPS5 ribosomal protein S5 -0.0324184
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0322426
DIAPH3 diaphanous-related formin 3 -0.0316169
RPS4X ribosomal protein S4, X-linked -0.0313393
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0304053
RPL30 ribosomal protein L30 -0.0302657
RPL5 ribosomal protein L5 -0.0301962
CENPF centromere protein F, 350/400kDa -0.0293473
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0293121
HMGB1 high mobility group box 1 -0.0293094
S100A9 S100 calcium binding protein A9 -0.0289613
EBNA1BP2 EBNA1 binding protein 2 -0.0289439
CAMKMT calmodulin-lysine N-methyltransferase -0.0289083
CCNI cyclin I -0.0288012
RPL7 ribosomal protein L7 -0.0287576
RPL4 ribosomal protein L4 -0.0284734
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0284463
GCLM glutamate-cysteine ligase, modifier subunit -0.027711
TPM4 tropomyosin 4 -0.0275998
RPS14 ribosomal protein S14 -0.0271508
S100A10 S100 calcium binding protein A10 -0.026876
TXNRD1 thioredoxin reductase 1 -0.0262208
IFI16 interferon, gamma-inducible protein 16 -0.0261408
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -0.0260125
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0258986
PDE4B phosphodiesterase 4B, cAMP-specific -0.0248685
RPL38 ribosomal protein L38 -0.0243557
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0242238
DEK DEK proto-oncogene -0.0242106
TUBB tubulin, beta class I -0.0241678