| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Regorafenib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Regorafenib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.167662 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.141286 |
| VEGFA | vascular endothelial growth factor A | 0.103841 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.100916 |
| PDE10A | phosphodiesterase 10A | 0.096584 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0915766 |
| LDHA | lactate dehydrogenase A | 0.0912319 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0824184 |
| EGR1 | early growth response 1 | 0.0789006 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0732317 |
| VCAN | versican | 0.0673504 |
| FRMD4A | FERM domain containing 4A | 0.0662705 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0643081 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0532059 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0516197 |
| RNF213 | ring finger protein 213 | 0.0506018 |
| NDRG1 | N-myc downstream regulated 1 | 0.0484431 |
| VIM | vimentin | 0.0470054 |
| SQSTM1 | sequestosome 1 | 0.0467064 |
| TNS3 | tensin 3 | 0.0463493 |
| ANXA2 | annexin A2 | 0.0445502 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0402345 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0402082 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 0.0400264 |
| C3 | complement component 3 | 0.0392745 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0384338 |
| HDAC9 | histone deacetylase 9 | 0.038304 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0377766 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0377483 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0376335 |
| MCL1 | myeloid cell leukemia 1 | 0.0334752 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0334206 |
| PRELID2 | PRELI domain containing 2 | 0.0319881 |
| JUN | jun proto-oncogene | 0.031857 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0304977 |
| PLIN2 | perilipin 2 | 0.0304764 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0299823 |
| FOSL1 | FOS-like antigen 1 | 0.0298367 |
| CADM1 | cell adhesion molecule 1 | 0.0297011 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0296051 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0282883 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0279819 |
| KLF6 | Kruppel-like factor 6 | 0.0275513 |
| FLNB | filamin B, beta | 0.0272788 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0270695 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0270404 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0264448 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0262096 |
| TENM2 | teneurin transmembrane protein 2 | 0.0256714 |
| RND3 | Rho family GTPase 3 | 0.0250859 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0250011 |
| THBS2 | thrombospondin 2 | 0.0248293 |
| PFKP | phosphofructokinase, platelet | 0.024412 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0242676 |
| NAV1 | neuron navigator 1 | 0.0242593 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0241076 |
| MYADM | myeloid-associated differentiation marker | 0.0239026 |
| BAG6 | BCL2-associated athanogene 6 | 0.0237736 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0237714 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0236662 |
| CCNL1 | cyclin L1 | 0.0234746 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0233838 |
| KRT19 | keratin 19, type I | 0.0233052 |
| FLOT1 | flotillin 1 | 0.0232259 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0231871 |
| ARF4 | ADP-ribosylation factor 4 | 0.0223225 |
| CEP250 | centrosomal protein 250kDa | 0.0223053 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0220015 |
| RLIM | ring finger protein, LIM domain interacting | 0.0219477 |
| MLPH | melanophilin | 0.0219046 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0218993 |
| EFNA5 | ephrin-A5 | 0.0218852 |
| ANXA1 | annexin A1 | 0.0217759 |
| VMP1 | vacuole membrane protein 1 | 0.0217364 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0215049 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0213791 |
| COL1A2 | collagen, type I, alpha 2 | 0.021137 |
| FAM20C | family with sequence similarity 20, member C | 0.0209955 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0209493 |
| CFB | complement factor B | 0.0208543 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0206845 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0206135 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0205343 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0202485 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0201413 |
| FRMPD4 | FERM and PDZ domain containing 4 | 0.0199205 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0195164 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0193075 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0192051 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.0191709 |
| CLMN | calmin (calponin-like, transmembrane) | 0.0190072 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0187651 |
| CTSB | cathepsin B | 0.0186018 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.0185763 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0181766 |
| SRSF3 | serine/arginine-rich splicing factor 3 | 0.0181028 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0180489 |
| ATXN1 | ataxin 1 | 0.0178281 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0176873 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0176344 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | -0.130225 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.129781 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.105778 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.100309 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0921227 |
| RPS2 | ribosomal protein S2 | -0.0863897 |
| MT2A | metallothionein 2A | -0.08513 |
| RPS6 | ribosomal protein S6 | -0.0796008 |
| RPS24 | ribosomal protein S24 | -0.0745482 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0702185 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0680345 |
| RPS12 | ribosomal protein S12 | -0.0660521 |
| LAMP2 | lysosomal-associated membrane protein 2 | -0.0641323 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0626808 |
| RPL37A | ribosomal protein L37a | -0.0625806 |
| SPAG9 | sperm associated antigen 9 | -0.0622669 |
| WTAP | Wilms tumor 1 associated protein | -0.0578435 |
| VCL | vinculin | -0.0561072 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.055324 |
| RPS3 | ribosomal protein S3 | -0.0550366 |
| NAV2 | neuron navigator 2 | -0.0548473 |
| HLA-B | major histocompatibility complex, class I, B | -0.0528269 |
| HMGA2 | high mobility group AT-hook 2 | -0.0521914 |
| RPS8 | ribosomal protein S8 | -0.0509259 |
| RPS23 | ribosomal protein S23 | -0.0507932 |
| CLTC | clathrin, heavy chain (Hc) | -0.0496823 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0494716 |
| FOXO3 | forkhead box O3 | -0.0494615 |
| KYNU | kynureninase | -0.0486161 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0470219 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0469224 |
| RPL26 | ribosomal protein L26 | -0.0468886 |
| JMJD1C | jumonji domain containing 1C | -0.0468209 |
| RPL36A | ribosomal protein L36a | -0.0465013 |
| GOLGA4 | golgin A4 | -0.0453164 |
| RPS25 | ribosomal protein S25 | -0.0452843 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0448395 |
| RPL11 | ribosomal protein L11 | -0.0447984 |
| STC1 | stanniocalcin 1 | -0.0440254 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0420355 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0416563 |
| RPL7 | ribosomal protein L7 | -0.0416559 |
| MKI67 | marker of proliferation Ki-67 | -0.041401 |
| RPL12 | ribosomal protein L12 | -0.0413365 |
| RPL7A | ribosomal protein L7a | -0.0407721 |
| AHNAK | AHNAK nucleoprotein | -0.0407499 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0404556 |
| RPL9 | ribosomal protein L9 | -0.0399473 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0398129 |
| MORF4L2 | mortality factor 4 like 2 | -0.0396288 |
| RPL15 | ribosomal protein L15 | -0.0384133 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0383939 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.0382032 |
| MSN | moesin | -0.0378484 |
| POTEF | POTE ankyrin domain family, member F | -0.0378238 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0375808 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0373934 |
| IPO7 | importin 7 | -0.0371332 |
| PHIP | pleckstrin homology domain interacting protein | -0.0367695 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0365228 |
| SFTPA2 | surfactant protein A2 | -0.0355952 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0352757 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0346482 |
| ERBIN | erbb2 interacting protein | -0.0342587 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0339913 |
| RPL32 | ribosomal protein L32 | -0.0338352 |
| RPL31 | ribosomal protein L31 | -0.0336546 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0334789 |
| RPLP2 | ribosomal protein, large, P2 | -0.0334546 |
| FTL | ferritin, light polypeptide | -0.033311 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0330349 |
| DUSP5 | dual specificity phosphatase 5 | -0.0330178 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0325263 |
| RPL27A | ribosomal protein L27a | -0.0324949 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0324595 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0324518 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0324158 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0322715 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0322587 |
| RPL38 | ribosomal protein L38 | -0.0319879 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0319301 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0319293 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0319032 |
| TMSB4X | thymosin beta 4, X-linked | -0.0315885 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0313479 |
| APP | amyloid beta (A4) precursor protein | -0.0312894 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0312528 |
| CDK13 | cyclin-dependent kinase 13 | -0.0311944 |
| RPL35 | ribosomal protein L35 | -0.0311546 |
| RASA2 | RAS p21 protein activator 2 | -0.0311468 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | -0.0310632 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.031029 |
| BICC1 | BicC family RNA binding protein 1 | -0.0310244 |
| RPL5 | ribosomal protein L5 | -0.030828 |
| RPS13 | ribosomal protein S13 | -0.0306532 |
| KLF12 | Kruppel-like factor 12 | -0.0304656 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0302974 |
| GPC6 | glypican 6 | -0.0300639 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0300377 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0300218 |
