Regorafenib_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Regorafenib perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Regorafenib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.090641
HILPDA hypoxia inducible lipid droplet-associated 0.066779
ATP13A3 ATPase type 13A3 0.0636948
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0631594
RBM39 RNA binding motif protein 39 0.059953
PTMA prothymosin, alpha 0.0567014
CAPRIN2 caprin family member 2 0.0557671
ITCH itchy E3 ubiquitin protein ligase 0.0557484
DSCAM Down syndrome cell adhesion molecule 0.0555001
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0510547
ZNF292 zinc finger protein 292 0.0500542
SETD5 SET domain containing 5 0.0481876
THSD4 thrombospondin, type I, domain containing 4 0.0480181
MRE11 MRE11 homolog, double strand break repair nuclease 0.0470833
FLNB filamin B, beta 0.0467319
NKTR natural killer cell triggering receptor 0.0459846
RAD51B RAD51 paralog B 0.0452026
PICALM phosphatidylinositol binding clathrin assembly protein 0.0449438
SDC4 syndecan 4 0.0438938
LDHA lactate dehydrogenase A 0.0434566
EEF2 eukaryotic translation elongation factor 2 0.0427295
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0422293
RSRC2 arginine/serine-rich coiled-coil 2 0.0417895
PDGFA platelet-derived growth factor alpha polypeptide 0.0417629
ABI2 abl-interactor 2 0.0410143
ESYT2 extended synaptotagmin-like protein 2 0.041007
FMNL2 formin-like 2 0.0406407
NF1 neurofibromin 1 0.040209
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0379891
SPAG9 sperm associated antigen 9 0.0378177
IGFBP3 insulin-like growth factor binding protein 3 0.0371838
RBM25 RNA binding motif protein 25 0.0370106
CUL4B cullin 4B 0.036008
GIGYF2 GRB10 interacting GYF protein 2 0.0354235
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0352472
SEPTIN2 septin 2 0.0345726
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0341051
DLG1 discs, large homolog 1 (Drosophila) 0.0338883
DTNA dystrobrevin, alpha 0.0335534
FAM13A family with sequence similarity 13, member A 0.0329035
CEP250 centrosomal protein 250kDa 0.03287
KIAA1958 KIAA1958 0.0323024
SCFD1 sec1 family domain containing 1 0.031954
NDRG1 N-myc downstream regulated 1 0.0318256
DERA deoxyribose-phosphate aldolase (putative) 0.0317612
FNBP4 formin binding protein 4 0.0317259
KDM5B lysine (K)-specific demethylase 5B 0.0316848
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0314182
TAS2R14 taste receptor, type 2, member 14 0.0311201
PTK2 protein tyrosine kinase 2 0.0303292
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0300505
ANKRD12 ankyrin repeat domain 12 0.0300026
SEC62 SEC62 homolog (S. cerevisiae) 0.0299576
CD2AP CD2-associated protein 0.0298417
AKAP12 A kinase (PRKA) anchor protein 12 0.0297322
UBE2B ubiquitin-conjugating enzyme E2B 0.0296419
SRP54 signal recognition particle 54kDa 0.0295465
MACF1 microtubule-actin crosslinking factor 1 0.0294039
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0293444
TM9SF2 transmembrane 9 superfamily member 2 0.0290982
SFPQ splicing factor proline/glutamine-rich 0.0290888
RBM5 RNA binding motif protein 5 0.0290083
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0289795
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.0287124
UBE2K ubiquitin-conjugating enzyme E2K 0.0286033
ANKRD36C ankyrin repeat domain 36C 0.0284183
NPTN neuroplastin 0.0281265
EIF4B eukaryotic translation initiation factor 4B 0.0279847
ANKRD36 ankyrin repeat domain 36 0.0278185
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0277085
WSB1 WD repeat and SOCS box containing 1 0.0277081
CASC3 cancer susceptibility candidate 3 0.027696
PRELID2 PRELI domain containing 2 0.027498
MTDH metadherin 0.0274855
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0274744
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0274473
AKAP9 A kinase (PRKA) anchor protein 9 0.0273262
SFXN1 sideroflexin 1 0.0271831
GGNBP2 gametogenetin binding protein 2 0.0271739
AKAP13 A kinase (PRKA) anchor protein 13 0.0269811
ZNF148 zinc finger protein 148 0.0269683
ZCCHC7 zinc finger, CCHC domain containing 7 0.0268987
RPS27A ribosomal protein S27a 0.0268816
TPM3 tropomyosin 3 0.0268748
TBC1D5 TBC1 domain family, member 5 0.0268113
RAB1A RAB1A, member RAS oncogene family 0.0267745
NCKAP1 NCK-associated protein 1 0.0266117
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0265753
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0264693
GOLGA4 golgin A4 0.0262795
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0260131
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.025968
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0258347
SRPK1 SRSF protein kinase 1 0.0256884
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.025519
TMF1 TATA element modulatory factor 1 0.0254734
PEAK1 pseudopodium-enriched atypical kinase 1 0.0249185
GPBP1 GC-rich promoter binding protein 1 0.0248327
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0247704
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0246655

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.304003
LOC112694756 uncharaterized LOC112694756 -0.109933
TPT1 tumor protein, translationally-controlled 1 -0.103961
TMSB10 thymosin beta 10 -0.102234
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0747162
FNDC3B fibronectin type III domain containing 3B -0.0675117
HMGA2 high mobility group AT-hook 2 -0.0556068
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0518658
IL6ST interleukin 6 signal transducer -0.0513905
NFE2L2 nuclear factor, erythroid 2-like 2 -0.050783
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0484
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0474307
FTH1 ferritin, heavy polypeptide 1 -0.0448529
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0443924
IER3 immediate early response 3 -0.0443058
SVIL supervillin -0.0441491
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0438008
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0435698
TPI1 triosephosphate isomerase 1 -0.0422331
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0421389
TXNRD1 thioredoxin reductase 1 -0.0410339
BIRC3 baculoviral IAP repeat containing 3 -0.0409671
CD44 CD44 molecule (Indian blood group) -0.0407936
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0393771
H3-3B H3.3 histone B -0.0388562
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0386501
POTEF POTE ankyrin domain family, member F -0.0382178
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0381194
RPLP1 ribosomal protein, large, P1 -0.0377883
RPL35A ribosomal protein L35a -0.0371468
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0368898
RPS25 ribosomal protein S25 -0.036817
TUBA1B tubulin, alpha 1b -0.0367739
CANX calnexin -0.036233
ATF7IP activating transcription factor 7 interacting protein -0.0361566
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0361313
RPS19 ribosomal protein S19 -0.0360578
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0357583
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0354046
FTL ferritin, light polypeptide -0.0347927
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0341737
FBXL17 F-box and leucine-rich repeat protein 17 -0.033729
TTC19 tetratricopeptide repeat domain 19 -0.0324395
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0313551
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0309728
ZFAND3 zinc finger, AN1-type domain 3 -0.0309268
PGK1 phosphoglycerate kinase 1 -0.0305529
BIRC6 baculoviral IAP repeat containing 6 -0.030244
ERBIN erbb2 interacting protein -0.030091
MORF4L1 mortality factor 4 like 1 -0.0300306
MEMO1 mediator of cell motility 1 -0.0292169
RPS3 ribosomal protein S3 -0.0291148
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0290694
ANO6 anoctamin 6 -0.0290675
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.028854
ZSWIM6 zinc finger, SWIM-type containing 6 -0.028614
CUL3 cullin 3 -0.0283261
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0282445
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0282222
GOLT1B golgi transport 1B -0.0278958
FAM3C family with sequence similarity 3, member C -0.0277176
SENP6 SUMO1/sentrin specific peptidase 6 -0.0273107
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0268387
OXSR1 oxidative stress responsive 1 -0.0267387
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0267322
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0265799
RACK1 receptor for activated C kinase 1 -0.0264396
GOLM2 golgi membrane protein 2 -0.0260026
CAVIN1 caveolae associated protein 1 -0.0260006
RPL27A ribosomal protein L27a -0.025949
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0257706
KPNB1 karyopherin (importin) beta 1 -0.0256882
BMERB1 bMERB domain containing 1 -0.0256229
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.025551
RSF1 remodeling and spacing factor 1 -0.0255052
ZCCHC14 zinc finger, CCHC domain containing 14 -0.0254868
RNF121 ring finger protein 121 -0.0253419
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0252099
JARID2 jumonji, AT rich interactive domain 2 -0.0249683
CDK6 cyclin-dependent kinase 6 -0.0249564
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0248258
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.0247208
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.024531
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0244969
LARP1 La ribonucleoprotein domain family, member 1 -0.0243377
CCNH cyclin H -0.0241916
NCOA1 nuclear receptor coactivator 1 -0.0241635
INTS6 integrator complex subunit 6 -0.0239941
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0238116
DSE dermatan sulfate epimerase -0.0236169
PGGT1B protein geranylgeranyltransferase type I, beta subunit -0.0235807
FMR1 fragile X mental retardation 1 -0.0235415
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0234486
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0233661
RTN4 reticulon 4 -0.0233061
MT2A metallothionein 2A -0.0231987
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0229172
QKI QKI, KH domain containing, RNA binding -0.0228471
BZW2 basic leucine zipper and W2 domains 2 -0.022799
RPS14 ribosomal protein S14 -0.0227887