Regulation of TP53 Degradation Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://reactome.org/PathwayBrowser/#/R-HSA-6804757
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Genes

36 proteins participating in the Regulation of TP53 Degradation pathway from the Reactome Pathways 2024 dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ATM ATM serine/threonine kinase
CCNA1 cyclin A1
CCNA2 cyclin A2
CCNG1 cyclin G1
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN2A cyclin-dependent kinase inhibitor 2A
CHEK2 checkpoint kinase 2
DAXX death-domain associated protein
MAPKAP1 mitogen-activated protein kinase associated protein 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
PDPK1 3-phosphoinositide dependent protein kinase 1
PHF20 PHD finger protein 20
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRR5 proline rich 5 (renal)
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RICTOR RPTOR independent companion of MTOR, complex 2
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
RPS27A ribosomal protein S27a
SGK1 serum/glucocorticoid regulated kinase 1
TP53 tumor protein p53
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
USP2 ubiquitin specific peptidase 2
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)