Regulation of insulin secretion Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
Description Any process that modulates the frequency, rate or extent of the regulated release of insulin. (Gene Ontology, GO_0050796)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-422356
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Genes

77 proteins participating in the Regulation of insulin secretion pathway from the Reactome Pathways dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY8 adenylate cyclase 8 (brain)
ADRA2A adrenoceptor alpha 2A
ADRA2C adrenoceptor alpha 2C
AKAP5 A kinase (PRKA) anchor protein 5
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CHRM3 cholinergic receptor, muscarinic 3
FFAR1 free fatty acid receptor 1
GCG glucagon
GLP1R glucagon-like peptide 1 receptor
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNAS GNAS complex locus
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4
GNB5 guanine nucleotide binding protein (G protein), beta 5
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG5 guanine nucleotide binding protein (G protein), gamma 5
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNG8 guanine nucleotide binding protein (G protein), gamma 8
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
INS insulin
IQGAP1 IQ motif containing GTPase activating protein 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
MARCKS myristoylated alanine-rich protein kinase C substrate
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB2 phospholipase C, beta 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCA protein kinase C, alpha
RAP1A RAP1A, member of RAS oncogene family
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SNAP25 synaptosomal-associated protein, 25kDa
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
SYT5 synaptotagmin V
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
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