Regulation of lipolysis in adipocytes Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Lipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. Lipolysis is under tight hormonal control. During fasting, catecholamines, by binding to Gs-coupled-adrenergic receptors (-AR), activate adenylate cyclase (AC) to increase cAMP and activate protein kinase A (PKA). PKA phosphorylates target protein such as hormone-sensitive lipase (HSL) and perilipin 1 (PLIN). PLIN phosphorylation is a key event in the sequential activation of TAG hydrolysis involving adipose triglyceride lipase (ATGL), HSL, and monoglyceride lipase (MGL). During the fed state, insulin, through activation of phosphodiesterase-3B (PDE-3B), inhibits catecholamine-induced lipolysis via the degradation of cAMP. (Kyoto Encyclopedia of Genes and Genomes, hsa04923)
External Link https://www.kegg.jp/entry/hsa04923
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Genes

58 proteins participating in the Regulation of lipolysis in adipocytes pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ABHD5 abhydrolase domain containing 5
ADCY1 adenylate cyclase 1 (brain)
ADCY2 adenylate cyclase 2 (brain)
ADCY4 adenylate cyclase 4
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
ADORA1 adenosine A1 receptor
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AQP7 aquaporin 7
CHGA chromogranin A
CIDEC cell death-inducing DFFA-like effector c
CLSTN1 calsyntenin 1
DAAM2-AS1 DAAM2 antisense RNA 1
FABP4 fatty acid binding protein 4, adipocyte
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAS GNAS complex locus
INS insulin
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
LIPE lipase, hormone-sensitive
LNCEGFL7OS lncRNA EGFL7 opposite strand
MGLL monoglyceride lipase
NPPA natriuretic peptide A
NPR1 natriuretic peptide receptor 1
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
PDE3B phosphodiesterase 3B, cGMP-inhibited
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLAAT2 phospholipase A and acyltransferase 2
PLAAT3 phospholipase A and acyltransferase 3
PLIN1 perilipin 1
PNPLA2 patatin-like phospholipase domain containing 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCA protein kinase C, alpha
PRKG1 protein kinase, cGMP-dependent, type I
PRKG2 protein kinase, cGMP-dependent, type II
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
TSHB thyroid stimulating hormone, beta
TSHR thyroid stimulating hormone receptor