| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Relugolix perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Relugolix_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.216888 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.150778 |
| PODXL | podocalyxin-like | 0.142567 |
| CALR | calreticulin | 0.138712 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.137238 |
| THBS2 | thrombospondin 2 | 0.12023 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0729196 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0638889 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0632249 |
| COL5A1 | collagen, type V, alpha 1 | 0.0628355 |
| FN1 | fibronectin 1 | 0.0586684 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0570901 |
| APP | amyloid beta (A4) precursor protein | 0.0569857 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0539064 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0538788 |
| CANX | calnexin | 0.0537542 |
| GOLGA4 | golgin A4 | 0.0502966 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0500087 |
| TMSB4X | thymosin beta 4, X-linked | 0.0470917 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0469619 |
| CDH13 | cadherin 13 | 0.0464202 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0461396 |
| CD109 | CD109 molecule | 0.0416128 |
| AHNAK | AHNAK nucleoprotein | 0.0413361 |
| PTMA | prothymosin, alpha | 0.0412972 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0408537 |
| MKI67 | marker of proliferation Ki-67 | 0.0395617 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0393612 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0388471 |
| FSTL1 | follistatin-like 1 | 0.0383975 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0381326 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.037488 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0367396 |
| TPM4 | tropomyosin 4 | 0.0365015 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0364196 |
| CAVIN1 | caveolae associated protein 1 | 0.036118 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0360489 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0359001 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0357368 |
| CENPF | centromere protein F, 350/400kDa | 0.035013 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0346884 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0345083 |
| ANXA2 | annexin A2 | 0.0343012 |
| DSPP | dentin sialophosphoprotein | 0.0341199 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0323083 |
| COL3A1 | collagen, type III, alpha 1 | 0.0321396 |
| S100A10 | S100 calcium binding protein A10 | 0.0316766 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0315624 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0314693 |
| RIGI | RNA sensor RIG-I | 0.0314657 |
| SRPK2 | SRSF protein kinase 2 | 0.0313043 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0303017 |
| PLXNA2 | plexin A2 | 0.0300025 |
| RPS2 | ribosomal protein S2 | 0.029783 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.0292103 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0289223 |
| GSE1 | Gse1 coiled-coil protein | 0.0286224 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0285748 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0283491 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0278943 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | 0.0275475 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0273077 |
| TPM3 | tropomyosin 3 | 0.0270363 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0269045 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0265354 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.0263699 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0263432 |
| SPAG9 | sperm associated antigen 9 | 0.0262665 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0260258 |
| CYTH3 | cytohesin 3 | 0.0254434 |
| KIF5B | kinesin family member 5B | 0.0251629 |
| TRABD2B | TraB domain containing 2B | 0.0251584 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0251163 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0248282 |
| PLAT | plasminogen activator, tissue | 0.0246888 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0240015 |
| DGKG | diacylglycerol kinase, gamma 90kDa | 0.0236676 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.023596 |
| LMO7 | LIM domain 7 | 0.0233452 |
| CEP350 | centrosomal protein 350kDa | 0.0231332 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0230598 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0230424 |
| RAI1 | retinoic acid induced 1 | 0.0229899 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0227648 |
| NAV2 | neuron navigator 2 | 0.0227594 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.022703 |
| FLT1 | fms-related tyrosine kinase 1 | 0.0224582 |
| FMN2 | formin 2 | 0.0222707 |
| ASPH | aspartate beta-hydroxylase | 0.0222468 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0220939 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.0220184 |
| INSIG1 | insulin induced gene 1 | 0.0218949 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0218545 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0217982 |
| AFF4 | AF4/FMR2 family, member 4 | 0.021723 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0216923 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0215561 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.02135 |
| LAMB1 | laminin, beta 1 | 0.0212809 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.0212411 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.180086 |
| TMSB10 | thymosin beta 10 | -0.176237 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.174984 |
| FNDC3B | fibronectin type III domain containing 3B | -0.109452 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0926064 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.075389 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0729425 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0716804 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0713058 |
| FBN1 | fibrillin 1 | -0.0697921 |
| NAV1 | neuron navigator 1 | -0.0693757 |
| STC1 | stanniocalcin 1 | -0.0682293 |
| GPC6 | glypican 6 | -0.060551 |
| NDRG1 | N-myc downstream regulated 1 | -0.0591826 |
| POTEF | POTE ankyrin domain family, member F | -0.0584881 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0563688 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0528801 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0520255 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0507865 |
| COL1A2 | collagen, type I, alpha 2 | -0.0497702 |
| VCL | vinculin | -0.0474661 |
| MX2 | MX dynamin-like GTPase 2 | -0.0470175 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0453942 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0439135 |
| MYADM | myeloid-associated differentiation marker | -0.04271 |
| EGFR | epidermal growth factor receptor | -0.042128 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.041581 |
| PRELID2 | PRELI domain containing 2 | -0.0405047 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0391555 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0390896 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0375977 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0371337 |
| MYOF | myoferlin | -0.0363226 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0355478 |
| INTS6 | integrator complex subunit 6 | -0.0353062 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0351818 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.035124 |
| MT1X | metallothionein 1X | -0.0349516 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0335353 |
| RUNX1 | runt-related transcription factor 1 | -0.033366 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0325197 |
| FLNB | filamin B, beta | -0.0320092 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0318386 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0317236 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0312577 |
| PFN1 | profilin 1 | -0.0306727 |
| TAGLN2 | transgelin 2 | -0.0296113 |
| ACTN4 | actinin, alpha 4 | -0.0292841 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0291598 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0290489 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0289238 |
| PCBP2 | poly(rC) binding protein 2 | -0.0285685 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0277915 |
| RBM25 | RNA binding motif protein 25 | -0.0274699 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0274269 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0273645 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0272707 |
| TAPBP | TAP binding protein (tapasin) | -0.0271436 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.026769 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0266428 |
| CBX3 | chromobox homolog 3 | -0.0265009 |
| GNAS | GNAS complex locus | -0.0261346 |
| SLC22A23 | solute carrier family 22, member 23 | -0.0257553 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0257396 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0256271 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0255563 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0255055 |
| HLA-C | major histocompatibility complex, class I, C | -0.0252967 |
| RASA2 | RAS p21 protein activator 2 | -0.0250696 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0249368 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0241099 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0240595 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0238722 |
| SMIM44 | small integral membrane protein 44 | -0.0235524 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0235086 |
| CD81 | CD81 molecule | -0.0234894 |
| CDK6 | cyclin-dependent kinase 6 | -0.0233761 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0231932 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0231185 |
| RBM39 | RNA binding motif protein 39 | -0.0231069 |
| SON | SON DNA binding protein | -0.0225959 |
| SHOC2 | soc-2 suppressor of clear homolog (C. elegans) | -0.0223735 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0222454 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0221278 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0220596 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0220423 |
| UBAP1 | ubiquitin associated protein 1 | -0.0220348 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0219777 |
| HDAC9 | histone deacetylase 9 | -0.0219543 |
| TENM3 | teneurin transmembrane protein 3 | -0.0219121 |
| TFG | TRK-fused gene | -0.0216112 |
| FNIP1 | folliculin interacting protein 1 | -0.0215056 |
| NKTR | natural killer cell triggering receptor | -0.0214838 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0212598 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0212516 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.021161 |
| SP100 | SP100 nuclear antigen | -0.021043 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0207741 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0206387 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0205951 |
