| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Relugolix perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Relugolix_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.172431 |
| NLGN1 | neuroligin 1 | 0.133688 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.117656 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.089582 |
| ASPH | aspartate beta-hydroxylase | 0.0834801 |
| VMP1 | vacuole membrane protein 1 | 0.0773744 |
| NHSL1 | NHS-like 1 | 0.0713441 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0709588 |
| PTMA | prothymosin, alpha | 0.0629826 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0620962 |
| CALR | calreticulin | 0.060456 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0597555 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0540251 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.052512 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0506782 |
| TPM3 | tropomyosin 3 | 0.0492787 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0489489 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0463601 |
| WWOX | WW domain containing oxidoreductase | 0.0447055 |
| RRM2 | ribonucleotide reductase M2 | 0.0446764 |
| JMJD1C | jumonji domain containing 1C | 0.0425346 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0416146 |
| ENO1 | enolase 1, (alpha) | 0.0404801 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0393164 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0381517 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0381198 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0362398 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0361318 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0353674 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0352 |
| ANXA1 | annexin A1 | 0.0349317 |
| PCDH9 | protocadherin 9 | 0.034409 |
| YAP1 | Yes-associated protein 1 | 0.034242 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0337165 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0336283 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0319912 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0307411 |
| TPM4 | tropomyosin 4 | 0.0305948 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0305739 |
| PRELID2 | PRELI domain containing 2 | 0.029965 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | 0.0299068 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0297768 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0297242 |
| RPS27A | ribosomal protein S27a | 0.0294857 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0294137 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0293689 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.029207 |
| TMEM41B | transmembrane protein 41B | 0.0280581 |
| CANX | calnexin | 0.0277685 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0275967 |
| USP34 | ubiquitin specific peptidase 34 | 0.0264316 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0259198 |
| RPL3 | ribosomal protein L3 | 0.0258626 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0255758 |
| MGAT4C | MGAT4 family, member C | 0.0254517 |
| IPO7 | importin 7 | 0.0251712 |
| CUX1 | cut-like homeobox 1 | 0.0247396 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0245651 |
| ANK2 | ankyrin 2, neuronal | 0.0244843 |
| VCAN | versican | 0.0244708 |
| EPHA5 | EPH receptor A5 | 0.0242754 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | 0.0238824 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0237801 |
| MYO1D | myosin ID | 0.0236731 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0233954 |
| BCHE | butyrylcholinesterase | 0.0229682 |
| CEP192 | centrosomal protein 192kDa | 0.0229218 |
| XPO1 | exportin 1 | 0.0227979 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0221831 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | 0.0221192 |
| RHOA | ras homolog family member A | 0.0220109 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0217097 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0216992 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0216344 |
| MTCL1 | microtubule crosslinking factor 1 | 0.0211866 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0209102 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0208255 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0207422 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0207262 |
| HDGF | hepatoma-derived growth factor | 0.020606 |
| MCL1 | myeloid cell leukemia 1 | 0.0205495 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0205212 |
| SET | SET nuclear proto-oncogene | 0.0204439 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0203433 |
| PKM | pyruvate kinase, muscle | 0.0203308 |
| PTK2 | protein tyrosine kinase 2 | 0.0199928 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0197884 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0196652 |
| EHBP1 | EH domain binding protein 1 | 0.0196195 |
| R3HDM2 | R3H domain containing 2 | 0.0195396 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.0194604 |
| RSF1 | remodeling and spacing factor 1 | 0.0194458 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0194054 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.019316 |
| CPOX | coproporphyrinogen oxidase | 0.0190283 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0190238 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0190025 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0189882 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0189082 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0188729 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.209293 |
| VIM | vimentin | -0.167068 |
| SLC38A2 | solute carrier family 38, member 2 | -0.125873 |
| TMSB10 | thymosin beta 10 | -0.12196 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0873387 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0721431 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0680206 |
| DST | dystonin | -0.0677587 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0664923 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0629024 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0628811 |
| AREG | amphiregulin | -0.060979 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0582636 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0569333 |
| PFN1 | profilin 1 | -0.0540717 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0510693 |
| PCDH7 | protocadherin 7 | -0.0502683 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0474399 |
| MYPN | myopalladin | -0.0471919 |
| ERBIN | erbb2 interacting protein | -0.0467555 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0454865 |
| EDN1 | endothelin 1 | -0.0446085 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0438334 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0430169 |
| NABP1 | nucleic acid binding protein 1 | -0.0420255 |
| RPLP0 | ribosomal protein, large, P0 | -0.0418983 |
| TPI1 | triosephosphate isomerase 1 | -0.0413744 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0409571 |
| ZNF804A | zinc finger protein 804A | -0.0406181 |
| HDAC9 | histone deacetylase 9 | -0.0400312 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0398463 |
| SYT1 | synaptotagmin I | -0.0390886 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.037911 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0378666 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0367558 |
| TENM3 | teneurin transmembrane protein 3 | -0.0366735 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0359828 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0358388 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | -0.0346021 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0344235 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0343956 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0342909 |
| ZNF217 | zinc finger protein 217 | -0.0333586 |
| PLK2 | polo-like kinase 2 | -0.0330821 |
| CLDN1 | claudin 1 | -0.0322606 |
| KLF6 | Kruppel-like factor 6 | -0.031406 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0312788 |
| RPL32 | ribosomal protein L32 | -0.0309816 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0304627 |
| CCDC88A | coiled-coil domain containing 88A | -0.0301907 |
| KDM5A | lysine (K)-specific demethylase 5A | -0.0300789 |
| RPL26 | ribosomal protein L26 | -0.0298552 |
| RPL18 | ribosomal protein L18 | -0.0296634 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.029519 |
| ECT2 | epithelial cell transforming 2 | -0.0295113 |
| EGR1 | early growth response 1 | -0.0292322 |
| CCN2 | cellular communication network factor 2 | -0.0290439 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0289227 |
| NUP98 | nucleoporin 98kDa | -0.0288949 |
| OXR1 | oxidation resistance 1 | -0.0286082 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0284447 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0282542 |
| POU2F1 | POU class 2 homeobox 1 | -0.0281417 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0274612 |
| USP15 | ubiquitin specific peptidase 15 | -0.026905 |
| SEC62 | SEC62 homolog (S. cerevisiae) | -0.0268884 |
| SETD5 | SET domain containing 5 | -0.0267986 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0267647 |
| RPL12 | ribosomal protein L12 | -0.0266523 |
| ELP4 | elongator acetyltransferase complex subunit 4 | -0.0265931 |
| YBX3 | Y box binding protein 3 | -0.0265532 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0265435 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0259868 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0259516 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0258111 |
| RBM39 | RNA binding motif protein 39 | -0.0258021 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0254998 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.025426 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0251918 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0247794 |
| RPL8 | ribosomal protein L8 | -0.0247611 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0247133 |
| CLPTM1L | CLPTM1-like | -0.0246315 |
| HMGA1 | high mobility group AT-hook 1 | -0.0246183 |
| ASTN2 | astrotactin 2 | -0.0244713 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0244324 |
| ZFP91 | ZFP91 zinc finger protein | -0.0243211 |
| MPG | N-methylpurine-DNA glycosylase | -0.0242909 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0242803 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0242309 |
| DUSP6 | dual specificity phosphatase 6 | -0.0242238 |
| LDHA | lactate dehydrogenase A | -0.0241701 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0241374 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.024102 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0240157 |
| WASF2 | WAS protein family, member 2 | -0.0238892 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0234186 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0234138 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0230653 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0230581 |
