Relugolix_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Relugolix perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Relugolix_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.129676
NALF1 NALCN channel auxiliary factor 1 0.121739
TRIO trio Rho guanine nucleotide exchange factor 0.0975067
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0693017
SOS1 son of sevenless homolog 1 (Drosophila) 0.0545903
CEMIP cell migration inducing protein, hyaluronan binding 0.0541561
AKAP12 A kinase (PRKA) anchor protein 12 0.0505762
ARHGAP9 Rho GTPase activating protein 9 0.0473155
NRP1 neuropilin 1 0.0460328
GREM2 gremlin 2, DAN family BMP antagonist 0.0459116
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0440179
TENM4 teneurin transmembrane protein 4 0.0418211
PTEN phosphatase and tensin homolog 0.0413623
PACS1 phosphofurin acidic cluster sorting protein 1 0.0399745
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0389595
PTPRK protein tyrosine phosphatase, receptor type, K 0.0367609
TPST1 tyrosylprotein sulfotransferase 1 0.0363804
PLPP1 phospholipid phosphatase 1 0.0351671
EPAS1 endothelial PAS domain protein 1 0.0320401
PDE10A phosphodiesterase 10A 0.0319471
ANTXR1 anthrax toxin receptor 1 0.0316349
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.0313009
UNC5C unc-5 homolog C (C. elegans) 0.0307993
COL4A5 collagen, type IV, alpha 5 0.0304381
CEMIP2 cell migration inducing hyaluronidase 2 0.0303609
ZBTB20 zinc finger and BTB domain containing 20 0.0289777
RPTOR regulatory associated protein of MTOR, complex 1 0.0289167
TCF12 transcription factor 12 0.0276038
PTPRE protein tyrosine phosphatase, receptor type, E 0.0272624
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0271824
CPNE8 copine VIII 0.0267733
COL4A2 collagen, type IV, alpha 2 0.0265043
ADGRG6 adhesion G protein-coupled receptor G6 0.0264191
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.0262438
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0262142
DNMBP dynamin binding protein 0.0261557
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0260683
DOCK5 dedicator of cytokinesis 5 0.0249796
SMAD6 SMAD family member 6 0.024901
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0248322
SOX5 SRY (sex determining region Y)-box 5 0.0245097
RUNX1 runt-related transcription factor 1 0.0243912
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.023921
THSD7A thrombospondin, type I, domain containing 7A 0.0237663
SMAD3 SMAD family member 3 0.0234654
JMJD1C jumonji domain containing 1C 0.0233474
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0232634
HMBOX1 homeobox containing 1 0.0230692
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0230271
SH3PXD2B SH3 and PX domains 2B 0.0229817
CHD9 chromodomain helicase DNA binding protein 9 0.0229048
SVIL supervillin 0.022801
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0225308
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0224214
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0224157
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0222206
VEGFA vascular endothelial growth factor A 0.0222154
FAM107B family with sequence similarity 107, member B 0.0220453
C1ORF21 chromosome 1 open reading frame 21 0.0218869
BMERB1 bMERB domain containing 1 0.02177
FTH1 ferritin, heavy polypeptide 1 0.0214383
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0213015
ANTXR2 anthrax toxin receptor 2 0.0211212
STC1 stanniocalcin 1 0.0211157
PDZRN3 PDZ domain containing ring finger 3 0.0211104
ZEB1 zinc finger E-box binding homeobox 1 0.0209618
ATP13A3 ATPase type 13A3 0.0209371
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0207952
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0207538
PCBP3 poly(rC) binding protein 3 0.0206807
SAMD5 sterile alpha motif domain containing 5 0.0201459
THSD4 thrombospondin, type I, domain containing 4 0.0201058
FRMD4A FERM domain containing 4A 0.0200775
MEF2A myocyte enhancer factor 2A 0.0200245
MSI2 musashi RNA-binding protein 2 0.019908
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.019894
TRIM24 tripartite motif containing 24 0.019892
LOXL2 lysyl oxidase-like 2 0.0198853
PSD3 pleckstrin and Sec7 domain containing 3 0.0198273
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0198015
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0194951
SYTL3 synaptotagmin-like 3 0.0192876
YEATS2 YEATS domain containing 2 0.0192294
ZNF804A zinc finger protein 804A 0.0191208
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0190865
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0190018
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.018979
GTF2I general transcription factor IIi 0.0188558
MICU3 mitochondrial calcium uptake family, member 3 0.0186231
ARHGAP24 Rho GTPase activating protein 24 0.018527
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 0.0184481
PHACTR2 phosphatase and actin regulator 2 0.0182586
COL18A1 collagen, type XVIII, alpha 1 0.018215
IGFBP3 insulin-like growth factor binding protein 3 0.0180504
RLIM ring finger protein, LIM domain interacting 0.018011
WNT5A wingless-type MMTV integration site family, member 5A 0.0179702
HIP1 huntingtin interacting protein 1 0.0178997
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0178544
ACBD6 acyl-CoA binding domain containing 6 0.0178338
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0176073

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.375357
VCL vinculin -0.189528
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.14926
PTMA prothymosin, alpha -0.123405
VIM vimentin -0.110659
RPL23 ribosomal protein L23 -0.104734
ZSWIM6 zinc finger, SWIM-type containing 6 -0.095668
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0858328
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0844149
RPL19 ribosomal protein L19 -0.0833857
TLE4 transducin-like enhancer of split 4 -0.081034
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0710369
TRIB2 tribbles pseudokinase 2 -0.0692259
DSCAM Down syndrome cell adhesion molecule -0.0679102
TPT1 tumor protein, translationally-controlled 1 -0.0641136
TMSB10 thymosin beta 10 -0.0579871
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.054487
RPL34 ribosomal protein L34 -0.0533861
AHNAK AHNAK nucleoprotein -0.0516575
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0511171
RPS24 ribosomal protein S24 -0.0510525
INTS6 integrator complex subunit 6 -0.0504722
RPS6 ribosomal protein S6 -0.0496031
RPS27A ribosomal protein S27a -0.0478959
CANX calnexin -0.0469913
COL1A1 collagen, type I, alpha 1 -0.045307
ZNF292 zinc finger protein 292 -0.0452613
MED13 mediator complex subunit 13 -0.0426905
DPH6 diphthamine biosynthesis 6 -0.0416416
FMN1 formin 1 -0.0414834
KDM4C lysine (K)-specific demethylase 4C -0.0414542
UBC ubiquitin C -0.0409544
DST dystonin -0.0406714
NAP1L1 nucleosome assembly protein 1-like 1 -0.0404954
ACTG1 actin gamma 1 -0.040352
CCDC47 coiled-coil domain containing 47 -0.0389694
KDM3A lysine (K)-specific demethylase 3A -0.0389636
EGR1 early growth response 1 -0.0389523
LMNA lamin A/C -0.0387462
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0379512
PGK1 phosphoglycerate kinase 1 -0.0370562
RPL35A ribosomal protein L35a -0.0369298
TPM1 tropomyosin 1 (alpha) -0.0368479
PCBP2 poly(rC) binding protein 2 -0.0368471
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0361598
RPL37A ribosomal protein L37a -0.0357995
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.035687
LIMA1 LIM domain and actin binding 1 -0.0352441
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0351495
FERMT2 fermitin family member 2 -0.0350882
MBD5 methyl-CpG binding domain protein 5 -0.034907
MEIS2 Meis homeobox 2 -0.0346529
MBNL1 muscleblind-like splicing regulator 1 -0.0338599
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0336378
PNISR PNN-interacting serine/arginine-rich protein -0.0334599
SQSTM1 sequestosome 1 -0.0333048
SNX14 sorting nexin 14 -0.0330444
LSAMP limbic system-associated membrane protein -0.0327701
LOC112694756 uncharaterized LOC112694756 -0.0324633
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0323764
STK38L serine/threonine kinase 38 like -0.0320683
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0315185
RPLP1 ribosomal protein, large, P1 -0.0313558
RPL32 ribosomal protein L32 -0.0313344
DLC1 DLC1 Rho GTPase activating protein -0.0312063
MCL1 myeloid cell leukemia 1 -0.0310553
CDK12 cyclin-dependent kinase 12 -0.0308086
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0308047
FTL ferritin, light polypeptide -0.0305019
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0299382
RPL27 ribosomal protein L27 -0.0299218
HMGB2 high mobility group box 2 -0.0294844
RPL11 ribosomal protein L11 -0.0294514
RPL38 ribosomal protein L38 -0.0290428
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0288973
NREP neuronal regeneration related protein -0.0286516
RACK1 receptor for activated C kinase 1 -0.0283347
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0279936
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0272557
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0271549
SON SON DNA binding protein -0.0269933
MYO1E myosin IE -0.0269026
SCG2 secretogranin II -0.0263991
HDLBP high density lipoprotein binding protein -0.0261903
PDLIM5 PDZ and LIM domain 5 -0.0261827
RPL12 ribosomal protein L12 -0.0260905
CADM2 cell adhesion molecule 2 -0.0260799
H3-3B H3.3 histone B -0.0260224
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.025939
RPL31 ribosomal protein L31 -0.0257969
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0257292
RPS19 ribosomal protein S19 -0.0255886
GNAS GNAS complex locus -0.0255518
RPS17 ribosomal protein S17 -0.0253484
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0253327
RPS14 ribosomal protein S14 -0.025228
COL3A1 collagen, type III, alpha 1 -0.0247543
RPS8 ribosomal protein S8 -0.024644
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0245642
S100A6 S100 calcium binding protein A6 -0.0243362