| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Relugolix perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Relugolix_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| STS | steroid sulfatase (microsomal), isozyme S | 0.0868161 |
| PHF3 | PHD finger protein 3 | 0.0681275 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.062773 |
| VCL | vinculin | 0.0595196 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0581269 |
| RNF213 | ring finger protein 213 | 0.0561439 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0546337 |
| PLSCR2 | phospholipid scramblase 2 | 0.0537478 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0530094 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0502522 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0501008 |
| ANXA2 | annexin A2 | 0.0485157 |
| ATP11A | ATPase, class VI, type 11A | 0.0455076 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0445984 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0414255 |
| MCL1 | myeloid cell leukemia 1 | 0.0389215 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0380682 |
| VMP1 | vacuole membrane protein 1 | 0.0372952 |
| RIGI | RNA sensor RIG-I | 0.0369311 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0367993 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0352835 |
| BCL2L1 | BCL2-like 1 | 0.0351867 |
| SPIDR | scaffolding protein involved in DNA repair | 0.03467 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.033916 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0323535 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0314499 |
| FAT1 | FAT atypical cadherin 1 | 0.0312245 |
| ITGA6 | integrin, alpha 6 | 0.0298735 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0294511 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.029377 |
| TNS4 | tensin 4 | 0.0290264 |
| SMAD3 | SMAD family member 3 | 0.0288304 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0285476 |
| MX1 | MX dynamin-like GTPase 1 | 0.0283319 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0277051 |
| MLPH | melanophilin | 0.0271524 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0268884 |
| TJP1 | tight junction protein 1 | 0.0268651 |
| STK24 | serine/threonine kinase 24 | 0.025698 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0253474 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0246341 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0245545 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0245315 |
| MYO5B | myosin VB | 0.0240752 |
| CCND3 | cyclin D3 | 0.0237875 |
| LMTK2 | lemur tyrosine kinase 2 | 0.023618 |
| USP34 | ubiquitin specific peptidase 34 | 0.0233121 |
| TPM3 | tropomyosin 3 | 0.0231937 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0228663 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0228182 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0217293 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.021707 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0215135 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0214008 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0213427 |
| ZC3H13 | zinc finger CCCH-type containing 13 | 0.0212864 |
| PDS5B | PDS5 cohesin associated factor B | 0.0212525 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0210383 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0207591 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0205701 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0205683 |
| SEPTIN9 | septin 9 | 0.0204819 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0204575 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0204186 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0201338 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0201 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0198886 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0198465 |
| APP | amyloid beta (A4) precursor protein | 0.019656 |
| SPINT1 | serine peptidase inhibitor, Kunitz type 1 | 0.0193969 |
| HSPA8 | heat shock 70kDa protein 8 | 0.019211 |
| ABHD17C | abhydrolase domain containing 17C | 0.0191724 |
| DISC1 | disrupted in schizophrenia 1 | 0.0190389 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0189992 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | 0.0189926 |
| DIAPH1 | diaphanous-related formin 1 | 0.0189497 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | 0.0187749 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0187693 |
| PSPC1 | paraspeckle component 1 | 0.0187242 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0187202 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0184312 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0182699 |
| UBAC2 | UBA domain containing 2 | 0.0180855 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0180785 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | 0.0180752 |
| CDK8 | cyclin-dependent kinase 8 | 0.0180511 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0180004 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0179076 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0178389 |
| CCNL1 | cyclin L1 | 0.0177973 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0177257 |
| SMYD3 | SET and MYND domain containing 3 | 0.0175683 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0173008 |
| SET | SET nuclear proto-oncogene | 0.0172154 |
| VEGFA | vascular endothelial growth factor A | 0.0171063 |
| PKM | pyruvate kinase, muscle | 0.0169276 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0167901 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0166585 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0164942 |
| POU2F2 | POU class 2 homeobox 2 | 0.0164434 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.116615 |
| B2M | beta-2-microglobulin | -0.113852 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.106658 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.106182 |
| HLA-B | major histocompatibility complex, class I, B | -0.101024 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0956289 |
| PTMA | prothymosin, alpha | -0.0928917 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0895443 |
| H1-0 | H1.0 linker histone | -0.0849624 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0849582 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.082382 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0794776 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0789601 |
| NDRG1 | N-myc downstream regulated 1 | -0.0722101 |
| ERBIN | erbb2 interacting protein | -0.0709177 |
| LMO7 | LIM domain 7 | -0.0648018 |
| XAF1 | XIAP associated factor 1 | -0.0641849 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0639651 |
| RRBP1 | ribosome binding protein 1 | -0.0630469 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0610611 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0600434 |
| AREG | amphiregulin | -0.0598326 |
| TMSB10 | thymosin beta 10 | -0.058283 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0572349 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0558764 |
| JUN | jun proto-oncogene | -0.0542302 |
| DIAPH3 | diaphanous-related formin 3 | -0.0535521 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.052947 |
| PERP | PERP, TP53 apoptosis effector | -0.0523235 |
| SQSTM1 | sequestosome 1 | -0.0513411 |
| RAB7A | RAB7A, member RAS oncogene family | -0.047991 |
| MKI67 | marker of proliferation Ki-67 | -0.0477585 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0469368 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0455724 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0446784 |
| KRT19 | keratin 19, type I | -0.043622 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0430469 |
| RBM39 | RNA binding motif protein 39 | -0.0426971 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0424378 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0421239 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0417049 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0413862 |
| HLA-E | major histocompatibility complex, class I, E | -0.0409737 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0405371 |
| MECOM | MDS1 and EVI1 complex locus | -0.0403892 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0402788 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0397964 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0397197 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0390645 |
| CENPF | centromere protein F, 350/400kDa | -0.0389038 |
| GOLGB1 | golgin B1 | -0.0387329 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0387274 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.038407 |
| HLA-C | major histocompatibility complex, class I, C | -0.0381027 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0378902 |
| ABLIM1 | actin binding LIM protein 1 | -0.0376948 |
| RPL35A | ribosomal protein L35a | -0.037265 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | -0.0371772 |
| EPCAM | epithelial cell adhesion molecule | -0.0365139 |
| TXNIP | thioredoxin interacting protein | -0.0363558 |
| TRIM2 | tripartite motif containing 2 | -0.0357683 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.035668 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0355104 |
| SPATA13 | spermatogenesis associated 13 | -0.0352646 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0345537 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0345326 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0343868 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0341602 |
| APOL1 | apolipoprotein L, 1 | -0.0339486 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0338066 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0335637 |
| S100A6 | S100 calcium binding protein A6 | -0.033462 |
| FOXP1 | forkhead box P1 | -0.0333174 |
| HDLBP | high density lipoprotein binding protein | -0.0332365 |
| NF1 | neurofibromin 1 | -0.03295 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0328457 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0328333 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0325147 |
| HLA-A | major histocompatibility complex, class I, A | -0.0324531 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0324506 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0321396 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.031904 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0316502 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.0313774 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0308234 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0307052 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0306104 |
| H3-3B | H3.3 histone B | -0.0305951 |
| BRCA2 | breast cancer 2, early onset | -0.0303154 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0301777 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0300295 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -0.0299377 |
| UBC | ubiquitin C | -0.029733 |
| MCU | mitochondrial calcium uniporter | -0.0293571 |
| AHNAK | AHNAK nucleoprotein | -0.0292201 |
| SERINC5 | serine incorporator 5 | -0.0289465 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.028864 |
| RPS19 | ribosomal protein S19 | -0.0286802 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0285799 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0285297 |
