| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Relugolix perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Relugolix_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.288747 |
| FN1 | fibronectin 1 | 0.163348 |
| COL6A3 | collagen, type VI, alpha 3 | 0.148193 |
| VEGFA | vascular endothelial growth factor A | 0.124139 |
| NDRG1 | N-myc downstream regulated 1 | 0.0947418 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0755079 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0734899 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.068372 |
| ATP13A3 | ATPase type 13A3 | 0.0676514 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0644516 |
| CALR | calreticulin | 0.0565883 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0509541 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0446311 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0420338 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0399061 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0381113 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0372415 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0364413 |
| ZNF292 | zinc finger protein 292 | 0.0348207 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0343245 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0341618 |
| CADM1 | cell adhesion molecule 1 | 0.0339043 |
| QKI | QKI, KH domain containing, RNA binding | 0.0327964 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0321734 |
| ARRDC3 | arrestin domain containing 3 | 0.0314703 |
| COL1A2 | collagen, type I, alpha 2 | 0.0310968 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0309169 |
| PDE10A | phosphodiesterase 10A | 0.0306645 |
| TPM4 | tropomyosin 4 | 0.0303753 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0301801 |
| PTK2 | protein tyrosine kinase 2 | 0.0299368 |
| USP3 | ubiquitin specific peptidase 3 | 0.0287043 |
| DST | dystonin | 0.0284445 |
| RLF | rearranged L-myc fusion | 0.0274534 |
| APP | amyloid beta (A4) precursor protein | 0.0269986 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0268349 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0264087 |
| FAM13A | family with sequence similarity 13, member A | 0.0262661 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0260888 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.026002 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0256431 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0251344 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.025075 |
| GOLGA4 | golgin A4 | 0.024426 |
| HYOU1 | hypoxia up-regulated 1 | 0.0244039 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0242515 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0239952 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0235846 |
| COPA | coatomer protein complex, subunit alpha | 0.0235723 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.023018 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0226667 |
| BRD4 | bromodomain containing 4 | 0.0226526 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0225534 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0223103 |
| PGK1 | phosphoglycerate kinase 1 | 0.0222914 |
| CD109 | CD109 molecule | 0.0220354 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0220139 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0216279 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0215598 |
| COL5A1 | collagen, type V, alpha 1 | 0.0214648 |
| ENO1 | enolase 1, (alpha) | 0.0214304 |
| DSPP | dentin sialophosphoprotein | 0.0211619 |
| ANXA5 | annexin A5 | 0.02114 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0210899 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0208561 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0208276 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0206262 |
| ZNF148 | zinc finger protein 148 | 0.0200416 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0199913 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0198347 |
| SNX9 | sorting nexin 9 | 0.0197605 |
| TPR | translocated promoter region, nuclear basket protein | 0.0196612 |
| CALU | calumenin | 0.0195307 |
| VCAN | versican | 0.0194888 |
| CDH13 | cadherin 13 | 0.0194094 |
| PDE8A | phosphodiesterase 8A | 0.0191201 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0190974 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0190354 |
| B2M | beta-2-microglobulin | 0.018942 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.018798 |
| POSTN | periostin, osteoblast specific factor | 0.018667 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0186429 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0185262 |
| SULF1 | sulfatase 1 | 0.0184041 |
| MRTFA | myocardin related transcription factor A | 0.0182289 |
| RPL3 | ribosomal protein L3 | 0.0181994 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0181609 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0181209 |
| KCTD9 | potassium channel tetramerization domain containing 9 | 0.0179944 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.017992 |
| COG5 | component of oligomeric golgi complex 5 | 0.0179912 |
| FOSL1 | FOS-like antigen 1 | 0.0179855 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0179703 |
| CCNY | cyclin Y | 0.0179038 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0178481 |
| LAMB1 | laminin, beta 1 | 0.0178148 |
| RYBP | RING1 and YY1 binding protein | 0.0175835 |
| PLEC | plectin | 0.0175422 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0174352 |
| RNF145 | ring finger protein 145 | 0.0174192 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.260603 |
| CD44 | CD44 molecule (Indian blood group) | -0.119224 |
| VIM | vimentin | -0.117474 |
| COL1A1 | collagen, type I, alpha 1 | -0.1006 |
| TMSB10 | thymosin beta 10 | -0.0994426 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0947432 |
| MT2A | metallothionein 2A | -0.0894974 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0730113 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0688714 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0455468 |
| PALLD | palladin, cytoskeletal associated protein | -0.04408 |
| GLIS3 | GLIS family zinc finger 3 | -0.0430097 |
| HLA-B | major histocompatibility complex, class I, B | -0.0427654 |
| OSMR | oncostatin M receptor | -0.0423207 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0422946 |
| VCL | vinculin | -0.0421669 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0419222 |
| IER3 | immediate early response 3 | -0.041285 |
| LOC112694756 | uncharaterized LOC112694756 | -0.03796 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0378289 |
| STC1 | stanniocalcin 1 | -0.0377619 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0374209 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0373183 |
| PDLIM5 | PDZ and LIM domain 5 | -0.036197 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0359921 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0357177 |
| INHBA | inhibin, beta A | -0.0355862 |
| RIGI | RNA sensor RIG-I | -0.033949 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0337649 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0319831 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0318595 |
| RPL35A | ribosomal protein L35a | -0.0317542 |
| HMGA2 | high mobility group AT-hook 2 | -0.0316617 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0301105 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0278949 |
| FBN1 | fibrillin 1 | -0.0278103 |
| IL6 | interleukin 6 | -0.0275342 |
| CLIC4 | chloride intracellular channel 4 | -0.0269346 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0262161 |
| MT1X | metallothionein 1X | -0.0260107 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0255775 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0245897 |
| SQSTM1 | sequestosome 1 | -0.0242942 |
| MTSS1 | metastasis suppressor 1 | -0.024193 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0237813 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0237548 |
| RPL19 | ribosomal protein L19 | -0.0235618 |
| ZNF644 | zinc finger protein 644 | -0.0232358 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0230876 |
| RPL28 | ribosomal protein L28 | -0.0228459 |
| FTL | ferritin, light polypeptide | -0.0227052 |
| RPL30 | ribosomal protein L30 | -0.0225722 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0225455 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0224198 |
| TAPBP | TAP binding protein (tapasin) | -0.0220659 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0208828 |
| RRBP1 | ribosome binding protein 1 | -0.0208289 |
| S100A6 | S100 calcium binding protein A6 | -0.0208235 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.020718 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0204644 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0200427 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0197212 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0197098 |
| EGR1 | early growth response 1 | -0.019662 |
| IL6ST | interleukin 6 signal transducer | -0.0196617 |
| PLSCR1 | phospholipid scramblase 1 | -0.019652 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0195046 |
| RPL11 | ribosomal protein L11 | -0.0194922 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0193987 |
| SLC22A23 | solute carrier family 22, member 23 | -0.0193858 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0192657 |
| RPLP1 | ribosomal protein, large, P1 | -0.0190337 |
| HLA-A | major histocompatibility complex, class I, A | -0.0189695 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0189499 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0189066 |
| RPS21 | ribosomal protein S21 | -0.0188512 |
| LDHA | lactate dehydrogenase A | -0.0187672 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0184724 |
| NABP1 | nucleic acid binding protein 1 | -0.0182887 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0182765 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0181306 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0180949 |
| RPL26 | ribosomal protein L26 | -0.0180422 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0174021 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0171788 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0169926 |
| SRGN | serglycin | -0.0169373 |
| ACTG1 | actin gamma 1 | -0.0168353 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0167432 |
| INTS6 | integrator complex subunit 6 | -0.0166886 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0164831 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0163087 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0162646 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0162515 |
| TMEM263 | transmembrane protein 263 | -0.0161824 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0161773 |
| GOLGB1 | golgin B1 | -0.0160811 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.016029 |
| RPS19 | ribosomal protein S19 | -0.0159681 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0158193 |
