Relugolix_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Relugolix perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Relugolix_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.195331
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0951596
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0900036
FN1 fibronectin 1 0.0773406
DSPP dentin sialophosphoprotein 0.0763853
SVIL supervillin 0.0592851
C3 complement component 3 0.0452578
AKAP12 A kinase (PRKA) anchor protein 12 0.0440131
GRB10 growth factor receptor-bound protein 10 0.0427875
TNS1 tensin 1 0.0417207
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0409711
TF transferrin 0.0386161
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0385861
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0374675
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0364264
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0349906
BCL2L1 BCL2-like 1 0.0338634
LMCD1 LIM and cysteine-rich domains 1 0.0332407
EHBP1 EH domain binding protein 1 0.0329167
TRIO trio Rho guanine nucleotide exchange factor 0.0325954
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0314187
FAT1 FAT atypical cadherin 1 0.0313129
VEGFA vascular endothelial growth factor A 0.0302
MACF1 microtubule-actin crosslinking factor 1 0.0297573
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0289214
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0285296
EIF4B eukaryotic translation initiation factor 4B 0.0272284
ZEB1 zinc finger E-box binding homeobox 1 0.0270503
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0265546
DOCK4 dedicator of cytokinesis 4 0.0254411
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0253706
ABTB3 ankyrin repeat and BTB domain containing 3 0.0253033
UBA6 ubiquitin-like modifier activating enzyme 6 0.0238059
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0230644
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0226555
DIAPH1 diaphanous-related formin 1 0.0226538
FBF1 Fas (TNFRSF6) binding factor 1 0.0211465
BCAR3 breast cancer anti-estrogen resistance 3 0.0206984
MYO1B myosin IB 0.0204039
NCKAP1 NCK-associated protein 1 0.020228
TMEM181 transmembrane protein 181 0.0201936
AFDN afadin, adherens junction formation factor 0.0200888
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0200681
DNAH17 dynein, axonemal, heavy chain 17 0.0200185
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0199357
MYH9 myosin, heavy chain 9, non-muscle 0.0198013
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0196703
ELL2 elongation factor, RNA polymerase II, 2 0.0195568
RASA2 RAS p21 protein activator 2 0.0192667
RAI14 retinoic acid induced 14 0.0192154
GPC6 glypican 6 0.0189192
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.018779
TBC1D5 TBC1 domain family, member 5 0.0186594
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0185549
SMYD3 SET and MYND domain containing 3 0.018158
NBAS neuroblastoma amplified sequence 0.0181218
KCMF1 potassium channel modulatory factor 1 0.0176428
OPTN optineurin 0.0176239
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.0175656
CCNL1 cyclin L1 0.0175204
RREB1 ras responsive element binding protein 1 0.0174574
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0172359
NKD1 naked cuticle homolog 1 (Drosophila) 0.017233
BCAS3 breast carcinoma amplified sequence 3 0.0171193
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0171127
ITGAV integrin, alpha V 0.0170242
RUNX1 runt-related transcription factor 1 0.0168746
EEF2 eukaryotic translation elongation factor 2 0.0165136
FAM117B family with sequence similarity 117, member B 0.0164562
ADAM9 ADAM metallopeptidase domain 9 0.0162758
YAP1 Yes-associated protein 1 0.0162642
FERMT1 fermitin family member 1 0.016244
RPL3 ribosomal protein L3 0.0162057
NGLY1 N-glycanase 1 0.0159267
SAMD4A sterile alpha motif domain containing 4A 0.0159039
CCDC93 coiled-coil domain containing 93 0.0157781
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0154991
PAPOLA poly(A) polymerase alpha 0.0153081
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0151683
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0151671
JMJD1C jumonji domain containing 1C 0.0150574
ANXA5 annexin A5 0.0150258
HSPA8 heat shock 70kDa protein 8 0.0149287
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0149255
CHD1L chromodomain helicase DNA binding protein 1-like 0.0148592
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0148489
AFF4 AF4/FMR2 family, member 4 0.0147268
FAF1 Fas (TNFRSF6) associated factor 1 0.0145616
TTC28 tetratricopeptide repeat domain 28 0.0145026
ITCH itchy E3 ubiquitin protein ligase 0.0144848
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0144407
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0144191
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0144165
SLMAP sarcolemma associated protein 0.0143266
RBM6 RNA binding motif protein 6 0.014325
KYNU kynureninase 0.0142391
HELZ helicase with zinc finger 0.0141925
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.0141401
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0139495
FAM13A family with sequence similarity 13, member A 0.0138586

decreased expression

Symbol Name Standardized Value
APOA2 apolipoprotein A-II -0.181929
TPT1 tumor protein, translationally-controlled 1 -0.141665
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.140873
TMSB10 thymosin beta 10 -0.105742
RPL37A ribosomal protein L37a -0.104256
RPS6 ribosomal protein S6 -0.0979246
RPS24 ribosomal protein S24 -0.0972356
RPL11 ribosomal protein L11 -0.096027
MT2A metallothionein 2A -0.0953774
RPL35A ribosomal protein L35a -0.0919748
RPS8 ribosomal protein S8 -0.0894797
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0864308
GPC3 glypican 3 -0.0857822
FTL ferritin, light polypeptide -0.0815883
RPL31 ribosomal protein L31 -0.0767792
TM4SF1 transmembrane 4 L six family member 1 -0.075298
SLC38A2 solute carrier family 38, member 2 -0.073641
RPLP1 ribosomal protein, large, P1 -0.0728769
RPL23 ribosomal protein L23 -0.0716947
RPS19 ribosomal protein S19 -0.0710701
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0693467
RPS27A ribosomal protein S27a -0.0683116
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0666202
RPS21 ribosomal protein S21 -0.0631007
RPL34 ribosomal protein L34 -0.0624376
RPS29 ribosomal protein S29 -0.0607973
AHSG alpha-2-HS-glycoprotein -0.060023
APOB apolipoprotein B -0.0563815
APOE apolipoprotein E -0.056344
STAU1 staufen double-stranded RNA binding protein 1 -0.0550272
HMGA1 high mobility group AT-hook 1 -0.0523954
RPS12 ribosomal protein S12 -0.0517419
RPLP2 ribosomal protein, large, P2 -0.0504289
RPS13 ribosomal protein S13 -0.0494011
ERRFI1 ERBB receptor feedback inhibitor 1 -0.049254
INTS6 integrator complex subunit 6 -0.0486408
ENO1 enolase 1, (alpha) -0.048172
RPL12 ribosomal protein L12 -0.0469955
EIF1 eukaryotic translation initiation factor 1 -0.0464892
NAP1L1 nucleosome assembly protein 1-like 1 -0.0452643
FMNL2 formin-like 2 -0.0439021
RPL9 ribosomal protein L9 -0.0433778
RPL19 ribosomal protein L19 -0.0431637
RPL30 ribosomal protein L30 -0.0429507
RPS23 ribosomal protein S23 -0.0423575
RPS16 ribosomal protein S16 -0.0416647
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0403827
RPL37 ribosomal protein L37 -0.0401758
RPL5 ribosomal protein L5 -0.0393306
RPS11 ribosomal protein S11 -0.0392618
IGFBP1 insulin-like growth factor binding protein 1 -0.0387032
SOX5 SRY (sex determining region Y)-box 5 -0.0386064
GNAS GNAS complex locus -0.0384449
PTMA prothymosin, alpha -0.0382906
AMBP alpha-1-microglobulin/bikunin precursor -0.0380635
LRMDA leucine rich melanocyte differentiation associated -0.0373569
TRIM26 tripartite motif containing 26 -0.0373423
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0369968
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0360748
RPL26 ribosomal protein L26 -0.0353864
RPS3 ribosomal protein S3 -0.0352424
RPS17 ribosomal protein S17 -0.0350984
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0350234
RPS15 ribosomal protein S15 -0.0345597
RPL7 ribosomal protein L7 -0.0343839
RPL32 ribosomal protein L32 -0.0341854
RPS14 ribosomal protein S14 -0.0336446
RPS10 ribosomal protein S10 -0.0334238
PDLIM5 PDZ and LIM domain 5 -0.0326779
ISG15 ISG15 ubiquitin-like modifier -0.0325541
RPS27 ribosomal protein S27 -0.0318875
IFI6 interferon, alpha-inducible protein 6 -0.0316935
FUS FUS RNA binding protein -0.0316485
RPL38 ribosomal protein L38 -0.0315063
RPS25 ribosomal protein S25 -0.0314928
RPLP0 ribosomal protein, large, P0 -0.0313074
NPAS2 neuronal PAS domain protein 2 -0.0309788
MCL1 myeloid cell leukemia 1 -0.0309642
SLC38A1 solute carrier family 38, member 1 -0.0308381
RPL28 ribosomal protein L28 -0.0307165
KIF21A kinesin family member 21A -0.0307025
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0306765
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0303157
PLIN2 perilipin 2 -0.030306
GDF15 growth differentiation factor 15 -0.0298547
GMDS GDP-mannose 4,6-dehydratase -0.0293233
S100A9 S100 calcium binding protein A9 -0.0291372
IFITM1 interferon induced transmembrane protein 1 -0.029114
RPL7A ribosomal protein L7a -0.0289509
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0284958
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0283063
PERP PERP, TP53 apoptosis effector -0.0281948
NDRG1 N-myc downstream regulated 1 -0.0281307
NPR2 natriuretic peptide receptor 2 -0.0278231
SDC4 syndecan 4 -0.0276679
VCL vinculin -0.02701
KDM4B lysine (K)-specific demethylase 4B -0.026677
SQSTM1 sequestosome 1 -0.026659
TPM4 tropomyosin 4 -0.0265716
RPS20 ribosomal protein S20 -0.0264033