| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Relugolix perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Relugolix_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MTSS1 | metastasis suppressor 1 | 0.180579 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.109602 |
| MYOF | myoferlin | 0.102978 |
| RAI14 | retinoic acid induced 14 | 0.0941102 |
| AOPEP | aminopeptidase O (putative) | 0.0935678 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0856371 |
| MEF2A | myocyte enhancer factor 2A | 0.0850684 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0823967 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0792831 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0774908 |
| LMO7 | LIM domain 7 | 0.0751817 |
| PTK2 | protein tyrosine kinase 2 | 0.0734953 |
| SMAD3 | SMAD family member 3 | 0.0702802 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0691104 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0672712 |
| OSMR | oncostatin M receptor | 0.0665342 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.06518 |
| PLEC | plectin | 0.0631564 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.057205 |
| NAV2 | neuron navigator 2 | 0.0559032 |
| SLK | STE20-like kinase | 0.0508554 |
| AHNAK | AHNAK nucleoprotein | 0.0493162 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0473453 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.047136 |
| B2M | beta-2-microglobulin | 0.0465868 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0464339 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0462027 |
| FOXO1 | forkhead box O1 | 0.0457157 |
| HLA-E | major histocompatibility complex, class I, E | 0.045506 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0438188 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0423129 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.042258 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0419813 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0412595 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0410682 |
| CD47 | CD47 molecule | 0.0407855 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0403679 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0402839 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0399313 |
| BLCAP | bladder cancer associated protein | 0.0387012 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0377737 |
| CDK6 | cyclin-dependent kinase 6 | 0.0376025 |
| CUL4B | cullin 4B | 0.0371117 |
| SQLE | squalene epoxidase | 0.037088 |
| OSBPL6 | oxysterol binding protein-like 6 | 0.0364633 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0363185 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0350935 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0350601 |
| PALLD | palladin, cytoskeletal associated protein | 0.0348789 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0345358 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0345039 |
| DGKH | diacylglycerol kinase, eta | 0.0339968 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0335255 |
| LONP2 | lon peptidase 2, peroxisomal | 0.0335128 |
| BCL2L1 | BCL2-like 1 | 0.0328432 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0324738 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0322598 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0320839 |
| RNF217 | ring finger protein 217 | 0.0319996 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0317671 |
| TGM2 | transglutaminase 2 | 0.0317007 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0315327 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.0315119 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 0.0313736 |
| EFNA5 | ephrin-A5 | 0.0311193 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0310928 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0308376 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0306777 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0303175 |
| AFAP1 | actin filament associated protein 1 | 0.0300841 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0298209 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0297647 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0294624 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0293919 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0293266 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0291268 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0289616 |
| APP | amyloid beta (A4) precursor protein | 0.0287051 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | 0.028606 |
| FN1 | fibronectin 1 | 0.0286045 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0282914 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0282746 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0279365 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.027699 |
| UVRAG | UV radiation resistance associated | 0.0274693 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0274471 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0270131 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0269813 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.026872 |
| C4BPB | complement component 4 binding protein, beta | 0.0267369 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0263643 |
| SAMHD1 | SAM domain and HD domain 1 | 0.0263423 |
| KIAA1217 | KIAA1217 | 0.0263319 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0263054 |
| THRAP3 | thyroid hormone receptor associated protein 3 | 0.026003 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | 0.0259066 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0259039 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0258685 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0255621 |
| XPO1 | exportin 1 | 0.0255395 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.107607 |
| TMSB10 | thymosin beta 10 | -0.0982455 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0947171 |
| NDRG1 | N-myc downstream regulated 1 | -0.0841504 |
| POTEF | POTE ankyrin domain family, member F | -0.0739411 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0736803 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0720462 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0684419 |
| S100A10 | S100 calcium binding protein A10 | -0.064373 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0577625 |
| LDHA | lactate dehydrogenase A | -0.0565313 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0552513 |
| PTMA | prothymosin, alpha | -0.0532606 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0510731 |
| RPS21 | ribosomal protein S21 | -0.0478049 |
| PFN1 | profilin 1 | -0.0468394 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0457668 |
| RPL11 | ribosomal protein L11 | -0.0449353 |
| FTL | ferritin, light polypeptide | -0.0447963 |
| RASAL2 | RAS protein activator like 2 | -0.0440987 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0440941 |
| INTS6 | integrator complex subunit 6 | -0.0440858 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0432893 |
| S100A11 | S100 calcium binding protein A11 | -0.0422712 |
| MT2A | metallothionein 2A | -0.0416493 |
| GNAS | GNAS complex locus | -0.0402788 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0396136 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0394827 |
| DUSP6 | dual specificity phosphatase 6 | -0.0388255 |
| VCL | vinculin | -0.0383999 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0376792 |
| TAGLN2 | transgelin 2 | -0.0366511 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0365193 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0361756 |
| PLAT | plasminogen activator, tissue | -0.0359339 |
| RPL9 | ribosomal protein L9 | -0.0355359 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0352597 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0346217 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0344071 |
| MT1X | metallothionein 1X | -0.0336565 |
| MYADM | myeloid-associated differentiation marker | -0.0334226 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.033296 |
| MORF4L2 | mortality factor 4 like 2 | -0.0325614 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0323562 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0323148 |
| CLU | clusterin | -0.0317167 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.03161 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.031465 |
| FBXO11 | F-box protein 11 | -0.0307826 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0303898 |
| RPLP2 | ribosomal protein, large, P2 | -0.0296116 |
| RPLP1 | ribosomal protein, large, P1 | -0.0295827 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0293347 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.029282 |
| S100A2 | S100 calcium binding protein A2 | -0.0291946 |
| ACER3 | alkaline ceramidase 3 | -0.0291229 |
| ITGA6 | integrin, alpha 6 | -0.029098 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0288334 |
| ANXA1 | annexin A1 | -0.028546 |
| CBX3 | chromobox homolog 3 | -0.0285326 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0283366 |
| TOP1 | topoisomerase (DNA) I | -0.0282809 |
| PLS3 | plastin 3 | -0.0282452 |
| SERTAD2 | SERTA domain containing 2 | -0.0282377 |
| RPL7A | ribosomal protein L7a | -0.0281701 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.027984 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0278459 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0276142 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0275336 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0274866 |
| IER3 | immediate early response 3 | -0.0274451 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.0274052 |
| ACTG1 | actin gamma 1 | -0.0273298 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0272211 |
| LMNA | lamin A/C | -0.0272135 |
| EZR | ezrin | -0.0270918 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0270169 |
| RND3 | Rho family GTPase 3 | -0.0269597 |
| S100A6 | S100 calcium binding protein A6 | -0.0267349 |
| COPA | coatomer protein complex, subunit alpha | -0.0267134 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0263871 |
| FRMD4A | FERM domain containing 4A | -0.0258992 |
| MYO10 | myosin X | -0.0258876 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0255573 |
| CST3 | cystatin C | -0.0248523 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.024642 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0243941 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.0241301 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0239719 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0239615 |
| TPI1 | triosephosphate isomerase 1 | -0.0239565 |
| S100A9 | S100 calcium binding protein A9 | -0.0235512 |
| RPLP0 | ribosomal protein, large, P0 | -0.023516 |
| PRDX1 | peroxiredoxin 1 | -0.0231334 |
| LRRC8A | leucine rich repeat containing 8 family, member A | -0.0230505 |
| HMGB1 | high mobility group box 1 | -0.0230418 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0230334 |
| RPS19 | ribosomal protein S19 | -0.0230137 |
| PABPN1 | poly(A) binding protein, nuclear 1 | -0.0229427 |
| TPX2 | TPX2, microtubule-associated | -0.0229085 |
