Relugolix_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Relugolix perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Relugolix_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.118231
LMO7 LIM domain 7 0.0723136
CEMIP cell migration inducing protein, hyaluronan binding 0.0702452
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0630241
SPTBN1 spectrin, beta, non-erythrocytic 1 0.039262
PRELID2 PRELI domain containing 2 0.0358582
CADPS Ca++-dependent secretion activator 0.0343171
PTPRK protein tyrosine phosphatase, receptor type, K 0.0331593
KRT8 keratin 8, type II 0.0321642
SMYD3 SET and MYND domain containing 3 0.029147
PARD3B par-3 family cell polarity regulator beta 0.0288706
ASPH aspartate beta-hydroxylase 0.0283307
VEGFA vascular endothelial growth factor A 0.027597
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0267082
PTEN phosphatase and tensin homolog 0.0266799
CEMIP2 cell migration inducing hyaluronidase 2 0.0266752
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0243688
ABHD2 abhydrolase domain containing 2 0.0239733
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0235978
PSD3 pleckstrin and Sec7 domain containing 3 0.0229266
DSPP dentin sialophosphoprotein 0.0226598
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0222293
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0212541
MYO1E myosin IE 0.0212097
CLCN3 chloride channel, voltage-sensitive 3 0.0211591
MUC13 mucin 13, cell surface associated 0.0207624
KDM4C lysine (K)-specific demethylase 4C 0.0202846
CCSER1 coiled-coil serine-rich protein 1 0.02022
FOXP1 forkhead box P1 0.0191662
ATXN1 ataxin 1 0.0191076
SAMD5 sterile alpha motif domain containing 5 0.0188258
PDE4D phosphodiesterase 4D, cAMP-specific 0.0178965
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.017839
METTL15 methyltransferase like 15 0.0176158
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0175688
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0174589
MED13 mediator complex subunit 13 0.017254
GLS2 glutaminase 2 (liver, mitochondrial) 0.0166958
ARHGAP26 Rho GTPase activating protein 26 0.0161823
AKAP13 A kinase (PRKA) anchor protein 13 0.0161745
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0160713
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0157918
PELI1 pellino E3 ubiquitin protein ligase 1 0.0155166
PDZD8 PDZ domain containing 8 0.0154606
EXT1 exostosin glycosyltransferase 1 0.0153128
AFF1 AF4/FMR2 family, member 1 0.0151729
NEBL nebulette 0.0148818
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0148568
RNF43 ring finger protein 43 0.0147791
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0147656
TSC22D1 TSC22 domain family, member 1 0.0146431
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0145745
PTPRB protein tyrosine phosphatase, receptor type, B 0.0145489
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0145139
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0145065
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0141375
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0140022
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0136565
FER fer (fps/fes related) tyrosine kinase 0.0136416
SOX9 SRY (sex determining region Y)-box 9 0.0135339
TBC1D5 TBC1 domain family, member 5 0.0135195
LPP LIM domain containing preferred translocation partner in lipoma 0.0135185
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0130641
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0129035
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0128283
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0127529
SVIL supervillin 0.0125785
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0124727
MACF1 microtubule-actin crosslinking factor 1 0.0123984
CDCP1 CUB domain containing protein 1 0.0123901
SHB Src homology 2 domain containing adaptor protein B 0.012388
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0120899
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0118868
EGFR epidermal growth factor receptor 0.0117712
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.011764
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0117501
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0116813
ARHGAP32 Rho GTPase activating protein 32 0.01157
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0115463
PATJ PATJ crumbs cell polarity complex component 0.0114757
SON SON DNA binding protein 0.0114717
ITPRID2 ITPR interacting domain containing 2 0.0114328
SHROOM3 shroom family member 3 0.0113208
FHIT fragile histidine triad 0.0113064
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0112713
ARL15 ADP-ribosylation factor-like 15 0.011254
ARHGAP12 Rho GTPase activating protein 12 0.0112313
USP6NL USP6 N-terminal like 0.0112124
ITGA6 integrin, alpha 6 0.0110227
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0109102
CDK19 cyclin-dependent kinase 19 0.0108886
ANO6 anoctamin 6 0.0108491
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.0107858
ARHGAP6 Rho GTPase activating protein 6 0.0107693
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0107516
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0107195
RNF217 ring finger protein 217 0.0107174
HSPA8 heat shock 70kDa protein 8 0.01067
ETV6 ets variant 6 0.0106514
LURAP1L leucine rich adaptor protein 1-like 0.0106418

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.388047
TPT1 tumor protein, translationally-controlled 1 -0.204965
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.159044
TMSB10 thymosin beta 10 -0.144257
RPS6 ribosomal protein S6 -0.134681
RPL35A ribosomal protein L35a -0.0946229
RPS8 ribosomal protein S8 -0.0882277
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0763802
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0716272
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.07146
RPL34 ribosomal protein L34 -0.0644287
RPLP1 ribosomal protein, large, P1 -0.0634452
RPS27A ribosomal protein S27a -0.0612585
RPS24 ribosomal protein S24 -0.0593451
RPL9 ribosomal protein L9 -0.0589756
IER3 immediate early response 3 -0.0581824
RPL37A ribosomal protein L37a -0.0570296
RPLP2 ribosomal protein, large, P2 -0.0558557
VCL vinculin -0.0541146
RPS3 ribosomal protein S3 -0.0511986
RPL23 ribosomal protein L23 -0.0505507
RPS29 ribosomal protein S29 -0.0500698
FTL ferritin, light polypeptide -0.0493949
RPS25 ribosomal protein S25 -0.0491524
RPL26 ribosomal protein L26 -0.0474265
RPS23 ribosomal protein S23 -0.047305
RPL31 ribosomal protein L31 -0.0470204
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0466307
RPS13 ribosomal protein S13 -0.0453678
EPCAM epithelial cell adhesion molecule -0.0445872
RPL12 ribosomal protein L12 -0.0440323
ACTG1 actin gamma 1 -0.0434208
RPL11 ribosomal protein L11 -0.0433463
RPS12 ribosomal protein S12 -0.0431249
S100A6 S100 calcium binding protein A6 -0.042812
RPL7A ribosomal protein L7a -0.0407925
GOLGA4 golgin A4 -0.0403882
RPS19 ribosomal protein S19 -0.0383449
RPL36 ribosomal protein L36 -0.0354029
NAP1L1 nucleosome assembly protein 1-like 1 -0.0352106
NPSR1 neuropeptide S receptor 1 -0.0334615
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0331885
NDRG1 N-myc downstream regulated 1 -0.0330668
AREG amphiregulin -0.0328483
KPNB1 karyopherin (importin) beta 1 -0.0325502
ANXA2 annexin A2 -0.032499
EIF1 eukaryotic translation initiation factor 1 -0.0323312
RPLP0 ribosomal protein, large, P0 -0.0322772
RPS14 ribosomal protein S14 -0.0321575
RPL19 ribosomal protein L19 -0.0318047
TFF1 trefoil factor 1 -0.0316421
AGR2 anterior gradient 2 -0.0316312
RPL36A ribosomal protein L36a -0.0309653
S100A10 S100 calcium binding protein A10 -0.0308032
RPL37 ribosomal protein L37 -0.0307419
TFF3 trefoil factor 3 (intestinal) -0.0302311
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0301918
RPL13A ribosomal protein L13a -0.0301191
RPL38 ribosomal protein L38 -0.0300284
RPS27 ribosomal protein S27 -0.0296544
TPM4 tropomyosin 4 -0.0295304
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0292447
RPS21 ribosomal protein S21 -0.0289462
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0287527
RPL5 ribosomal protein L5 -0.0284906
RPL8 ribosomal protein L8 -0.0283497
RAB1A RAB1A, member RAS oncogene family -0.0279336
S100P S100 calcium binding protein P -0.0269097
PNISR PNN-interacting serine/arginine-rich protein -0.0266869
EIF5B eukaryotic translation initiation factor 5B -0.0265146
RPS17 ribosomal protein S17 -0.0264601
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0263685
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0257829
RPL27A ribosomal protein L27a -0.0254365
RPS11 ribosomal protein S11 -0.0252593
SETD5 SET domain containing 5 -0.0251315
GCC2 GRIP and coiled-coil domain containing 2 -0.0251053
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0250759
ATP5F1B ATP synthase F1 subunit beta -0.0246354
RPL15 ribosomal protein L15 -0.0246066
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.024581
WAC WW domain containing adaptor with coiled-coil -0.0244127
B2M beta-2-microglobulin -0.0242774
ANKRD11 ankyrin repeat domain 11 -0.0241577
IARS1 isoleucyl-tRNA synthetase 1 -0.0239459
RPS16 ribosomal protein S16 -0.0238757
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0236102
PIGR polymeric immunoglobulin receptor -0.0235105
RPL7 ribosomal protein L7 -0.0230174
H3-3B H3.3 histone B -0.0228834
RPL28 ribosomal protein L28 -0.0228788
MYL12B myosin, light chain 12B, regulatory -0.0227891
KDM3A lysine (K)-specific demethylase 3A -0.0225275
GARS1 glycyl-tRNA synthetase 1 -0.0224827
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0222353
LOC102724023 ES1 protein homolog, mitochondrial -0.0221729
VDAC1 voltage-dependent anion channel 1 -0.0221339
RBM39 RNA binding motif protein 39 -0.0216184
GNAS GNAS complex locus -0.0207746
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0205096