| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Relugolix perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Relugolix_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TM4SF1 | transmembrane 4 L six family member 1 | 0.144011 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.113696 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.107335 |
| TXNRD1 | thioredoxin reductase 1 | 0.100038 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0964025 |
| EREG | epiregulin | 0.0795274 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0766923 |
| DST | dystonin | 0.0705123 |
| CAPRIN2 | caprin family member 2 | 0.0704572 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0660904 |
| TSC22D1 | TSC22 domain family, member 1 | 0.060103 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.059785 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0585627 |
| VCL | vinculin | 0.0561976 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.052033 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0514739 |
| EMP1 | epithelial membrane protein 1 | 0.0496548 |
| RAB27B | RAB27B, member RAS oncogene family | 0.048741 |
| APP | amyloid beta (A4) precursor protein | 0.0466537 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0461586 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.045709 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0456689 |
| TMSB4X | thymosin beta 4, X-linked | 0.0455253 |
| RUNX1 | runt-related transcription factor 1 | 0.0451797 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0421669 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0421561 |
| F2R | coagulation factor II (thrombin) receptor | 0.0379731 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.0376546 |
| ENO1 | enolase 1, (alpha) | 0.0365034 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0358451 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.034746 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0340928 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0339928 |
| LDHA | lactate dehydrogenase A | 0.0338396 |
| PGK1 | phosphoglycerate kinase 1 | 0.0337157 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0333113 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.033265 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0325666 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | 0.0325246 |
| CDCP1 | CUB domain containing protein 1 | 0.0323577 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0309836 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0280487 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0279098 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0271313 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0270108 |
| H1-0 | H1.0 linker histone | 0.0267912 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0267674 |
| SLK | STE20-like kinase | 0.0264328 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0263152 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0262134 |
| UBC | ubiquitin C | 0.0262011 |
| CD44 | CD44 molecule (Indian blood group) | 0.0259554 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0258851 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.025747 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0254339 |
| PLK2 | polo-like kinase 2 | 0.0251893 |
| JMJD1C | jumonji domain containing 1C | 0.0248408 |
| KLF6 | Kruppel-like factor 6 | 0.0247768 |
| SVIL | supervillin | 0.0247467 |
| CLTC | clathrin, heavy chain (Hc) | 0.0247214 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0243708 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0242355 |
| USP12 | ubiquitin specific peptidase 12 | 0.0242057 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0240469 |
| ZNF217 | zinc finger protein 217 | 0.0239663 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0238393 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.023813 |
| TPM4 | tropomyosin 4 | 0.0231148 |
| SPAG9 | sperm associated antigen 9 | 0.0230336 |
| TLK1 | tousled-like kinase 1 | 0.0228455 |
| PYGL | phosphorylase, glycogen, liver | 0.0226554 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0221409 |
| AHNAK | AHNAK nucleoprotein | 0.0220447 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0219232 |
| RPL4 | ribosomal protein L4 | 0.0218307 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0218185 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0214847 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0214635 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.0214256 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.021417 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0213114 |
| ANGPTL4 | angiopoietin-like 4 | 0.0211705 |
| KRT18 | keratin 18, type I | 0.020933 |
| EZR | ezrin | 0.0208215 |
| PDE10A | phosphodiesterase 10A | 0.0207678 |
| MT1E | metallothionein 1E | 0.0206383 |
| VMP1 | vacuole membrane protein 1 | 0.0204565 |
| CALR | calreticulin | 0.0203621 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0203447 |
| RPS2 | ribosomal protein S2 | 0.0197227 |
| HPCAL1 | hippocalcin-like 1 | 0.0197087 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0197 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.019213 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0190332 |
| TMEM41B | transmembrane protein 41B | 0.0190329 |
| SOCS6 | suppressor of cytokine signaling 6 | 0.0186215 |
| CANX | calnexin | 0.0185683 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0185443 |
| NGLY1 | N-glycanase 1 | 0.0184986 |
| UPP1 | uridine phosphorylase 1 | 0.0184907 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.193356 |
| TMSB10 | thymosin beta 10 | -0.143731 |
| POTEF | POTE ankyrin domain family, member F | -0.139771 |
| PTMA | prothymosin, alpha | -0.117809 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.11488 |
| MT2A | metallothionein 2A | -0.0708895 |
| RPL35A | ribosomal protein L35a | -0.0695314 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0639131 |
| RPS19 | ribosomal protein S19 | -0.0633962 |
| RPS6 | ribosomal protein S6 | -0.0632666 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0617624 |
| RPL23 | ribosomal protein L23 | -0.0593078 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0584822 |
| TNS3 | tensin 3 | -0.0518953 |
| HMGA1 | high mobility group AT-hook 1 | -0.0469998 |
| RNF213 | ring finger protein 213 | -0.045415 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0443056 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0428356 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0417629 |
| PFN1 | profilin 1 | -0.0416816 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0415692 |
| RPL36 | ribosomal protein L36 | -0.0413208 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0410659 |
| HLA-A | major histocompatibility complex, class I, A | -0.0406093 |
| INTS6 | integrator complex subunit 6 | -0.0401667 |
| SP100 | SP100 nuclear antigen | -0.038309 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0380294 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0377144 |
| RPL12 | ribosomal protein L12 | -0.0351211 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0349567 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0337167 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0336275 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0332605 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.033201 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0330997 |
| PTK2 | protein tyrosine kinase 2 | -0.0325198 |
| HLA-B | major histocompatibility complex, class I, B | -0.0320221 |
| PCBP2 | poly(rC) binding protein 2 | -0.0317331 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0316526 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0316391 |
| RPS23 | ribosomal protein S23 | -0.0305495 |
| RPL31 | ribosomal protein L31 | -0.0303784 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0298353 |
| S100A9 | S100 calcium binding protein A9 | -0.0294098 |
| FTL | ferritin, light polypeptide | -0.0287961 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0287124 |
| COL5A2 | collagen, type V, alpha 2 | -0.0286782 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0283645 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0281228 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0275139 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0274141 |
| RPL8 | ribosomal protein L8 | -0.0271827 |
| TAPBP | TAP binding protein (tapasin) | -0.0271682 |
| RPS8 | ribosomal protein S8 | -0.0269103 |
| EHBP1 | EH domain binding protein 1 | -0.0268622 |
| TP63 | tumor protein p63 | -0.0268116 |
| TXNIP | thioredoxin interacting protein | -0.0263752 |
| RBM25 | RNA binding motif protein 25 | -0.0260852 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0260404 |
| RPL11 | ribosomal protein L11 | -0.0259925 |
| RPL28 | ribosomal protein L28 | -0.0256844 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0254532 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0253919 |
| DIAPH3 | diaphanous-related formin 3 | -0.0253885 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0253792 |
| TPI1 | triosephosphate isomerase 1 | -0.0252853 |
| CENPF | centromere protein F, 350/400kDa | -0.025171 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | -0.0250322 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0249653 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0247202 |
| RPL19 | ribosomal protein L19 | -0.02435 |
| RPL35 | ribosomal protein L35 | -0.024346 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0241517 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0241471 |
| AEBP2 | AE binding protein 2 | -0.0240038 |
| EFNA5 | ephrin-A5 | -0.0239082 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0237768 |
| SON | SON DNA binding protein | -0.023615 |
| EPHA4 | EPH receptor A4 | -0.023087 |
| RPLP2 | ribosomal protein, large, P2 | -0.0229785 |
| RPS14 | ribosomal protein S14 | -0.0228635 |
| ZMIZ2 | zinc finger, MIZ-type containing 2 | -0.0227899 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0226956 |
| ATN1 | atrophin 1 | -0.0225935 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0225165 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | -0.0223152 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0222276 |
| RPLP1 | ribosomal protein, large, P1 | -0.0221596 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0221285 |
| RPL37A | ribosomal protein L37a | -0.021901 |
| FNBP1 | formin binding protein 1 | -0.0217053 |
| UBAP2 | ubiquitin associated protein 2 | -0.021694 |
| RPS29 | ribosomal protein S29 | -0.0216734 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0216307 |
| RPL34 | ribosomal protein L34 | -0.0216134 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0215831 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.021566 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | -0.0215418 |
| RAD51B | RAD51 paralog B | -0.0214724 |
| PABPN1 | poly(A) binding protein, nuclear 1 | -0.0213972 |
