| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Relugolix perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Relugolix_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.105326 |
| LAMC2 | laminin, gamma 2 | 0.103523 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.102999 |
| LAMA4 | laminin, alpha 4 | 0.100232 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0951207 |
| GRAMD1B | GRAM domain containing 1B | 0.0870641 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0732734 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0680294 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0661754 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0628067 |
| SLTM | SAFB-like, transcription modulator | 0.0588031 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0582769 |
| OSMR | oncostatin M receptor | 0.0575985 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.057524 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0567132 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0544628 |
| EFNA5 | ephrin-A5 | 0.0534244 |
| ANXA2 | annexin A2 | 0.0528327 |
| AHNAK | AHNAK nucleoprotein | 0.0513343 |
| CES1 | carboxylesterase 1 | 0.0496655 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0486473 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0484279 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0476375 |
| H1-0 | H1.0 linker histone | 0.0475574 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0465213 |
| LAMB3 | laminin, beta 3 | 0.0459792 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0439504 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0428709 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0414797 |
| DOCK5 | dedicator of cytokinesis 5 | 0.041007 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0393391 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0392687 |
| ABLIM1 | actin binding LIM protein 1 | 0.038639 |
| HDLBP | high density lipoprotein binding protein | 0.037617 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0373461 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0360622 |
| NTN4 | netrin 4 | 0.0353105 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0346557 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0344984 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.0343423 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0335883 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0334798 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0334522 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0328999 |
| GM2A | GM2 ganglioside activator | 0.0319884 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0315102 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0314877 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0302984 |
| B2M | beta-2-microglobulin | 0.0298646 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0297176 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0294586 |
| EMP1 | epithelial membrane protein 1 | 0.0293574 |
| FOXP1 | forkhead box P1 | 0.0292342 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0289936 |
| RAB10 | RAB10, member RAS oncogene family | 0.0287887 |
| DSPP | dentin sialophosphoprotein | 0.0283897 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0282134 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0277749 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0276789 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0273147 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0272634 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0269486 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0264319 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0260652 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0257455 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0254527 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0254365 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0253434 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0252803 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.025243 |
| KRT8 | keratin 8, type II | 0.0251327 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0250413 |
| TRIM56 | tripartite motif containing 56 | 0.0249992 |
| TXNRD1 | thioredoxin reductase 1 | 0.0249539 |
| MRTFB | myocardin related transcription factor B | 0.0249443 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0248991 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0240852 |
| STC1 | stanniocalcin 1 | 0.0238058 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0228557 |
| GPC5 | glypican 5 | 0.0228484 |
| TNS3 | tensin 3 | 0.0225546 |
| ARF1 | ADP-ribosylation factor 1 | 0.0224882 |
| SCEL | sciellin | 0.0221858 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0221063 |
| TAOK3 | TAO kinase 3 | 0.0220125 |
| SMYD3 | SET and MYND domain containing 3 | 0.0217175 |
| SQOR | sulfide quinone oxidoreductase | 0.021289 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0212527 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0211795 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0211719 |
| CD163L1 | CD163 molecule-like 1 | 0.0211009 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0209793 |
| RNF213 | ring finger protein 213 | 0.0209492 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0207467 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0205282 |
| IFNGR2 | interferon gamma receptor 2 (interferon gamma transducer 1) | 0.0202614 |
| RNF145 | ring finger protein 145 | 0.020231 |
| RACK1 | receptor for activated C kinase 1 | 0.02021 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0202083 |
| EXOC6B | exocyst complex component 6B | 0.0201876 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.209851 |
| NDRG1 | N-myc downstream regulated 1 | -0.179109 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.135528 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0928469 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0868422 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0764292 |
| SPAG9 | sperm associated antigen 9 | -0.0739465 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0703512 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0680058 |
| RBM39 | RNA binding motif protein 39 | -0.0669253 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0610386 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0599589 |
| FAM13A | family with sequence similarity 13, member A | -0.0590098 |
| MCL1 | myeloid cell leukemia 1 | -0.0583372 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0576625 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0544574 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0542743 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0540253 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.0536892 |
| SMAD3 | SMAD family member 3 | -0.0534325 |
| FNIP1 | folliculin interacting protein 1 | -0.0528534 |
| ZNF292 | zinc finger protein 292 | -0.0506065 |
| RPS6 | ribosomal protein S6 | -0.0468174 |
| SEC61G | Sec61 gamma subunit | -0.0455659 |
| TMEM87A | transmembrane protein 87A | -0.0437789 |
| EGR1 | early growth response 1 | -0.0434272 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0434199 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0429729 |
| GOLGA4 | golgin A4 | -0.0428561 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0426393 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0424804 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.041896 |
| MKI67 | marker of proliferation Ki-67 | -0.0414195 |
| MT2A | metallothionein 2A | -0.0408443 |
| RPS2 | ribosomal protein S2 | -0.0407381 |
| PDE8A | phosphodiesterase 8A | -0.0387105 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0384534 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0383737 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0376039 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0373343 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0367223 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0364867 |
| PCBP2 | poly(rC) binding protein 2 | -0.0363068 |
| GPC6 | glypican 6 | -0.0360068 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0358635 |
| SON | SON DNA binding protein | -0.0355814 |
| DTNA | dystrobrevin, alpha | -0.0355709 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0353463 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0351045 |
| NUP58 | nucleoporin 58 | -0.0350481 |
| USP34 | ubiquitin specific peptidase 34 | -0.0350375 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0347047 |
| MSN | moesin | -0.0346706 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.0342312 |
| SETD5 | SET domain containing 5 | -0.0342128 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0339146 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0335136 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0331515 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0328931 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0323312 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0321864 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0316418 |
| RPL37A | ribosomal protein L37a | -0.0312427 |
| ENSA | endosulfine alpha | -0.0300215 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0299779 |
| POTEF | POTE ankyrin domain family, member F | -0.029688 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0294687 |
| SUCO | SUN domain containing ossification factor | -0.0291837 |
| RPL7 | ribosomal protein L7 | -0.0290852 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0289073 |
| TMF1 | TATA element modulatory factor 1 | -0.0286905 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.0286613 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0286168 |
| CCNL1 | cyclin L1 | -0.0280418 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0279525 |
| TFG | TRK-fused gene | -0.0277485 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0270928 |
| CCNK | cyclin K | -0.0270081 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0265357 |
| CLTC | clathrin, heavy chain (Hc) | -0.0263629 |
| PYGL | phosphorylase, glycogen, liver | -0.0263551 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0261457 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0260561 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0259244 |
| SRP54 | signal recognition particle 54kDa | -0.0257376 |
| GOLGB1 | golgin B1 | -0.0256955 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0256275 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.025291 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0249429 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | -0.0249097 |
| NBAS | neuroblastoma amplified sequence | -0.024908 |
| SEPTIN2 | septin 2 | -0.0248502 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.024837 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0247328 |
| ZNF638 | zinc finger protein 638 | -0.0246567 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0245526 |
| RPL9 | ribosomal protein L9 | -0.0245503 |
| PAPOLA | poly(A) polymerase alpha | -0.0243158 |
| NOP58 | NOP58 ribonucleoprotein | -0.0242983 |
| SLMAP | sarcolemma associated protein | -0.0240974 |
