| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Relugolix perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Relugolix_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SMAD3 | SMAD family member 3 | 0.13947 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.122177 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.11457 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0843855 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0806503 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0771295 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0657864 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.063221 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0617128 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0590149 |
| VEGFA | vascular endothelial growth factor A | 0.0541691 |
| VMP1 | vacuole membrane protein 1 | 0.0510948 |
| TGM2 | transglutaminase 2 | 0.0495123 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0486711 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0478292 |
| NAV2 | neuron navigator 2 | 0.0458122 |
| FAM20C | family with sequence similarity 20, member C | 0.0454598 |
| PCBP2 | poly(rC) binding protein 2 | 0.0453054 |
| RUNX1 | runt-related transcription factor 1 | 0.0422796 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0409564 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0404953 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0401829 |
| MYO10 | myosin X | 0.0381237 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0377684 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.037212 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0356097 |
| LOXL2 | lysyl oxidase-like 2 | 0.0349889 |
| KYNU | kynureninase | 0.032829 |
| SIK3 | SIK family kinase 3 | 0.0325585 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0320537 |
| COPA | coatomer protein complex, subunit alpha | 0.0316555 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.031459 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0310208 |
| ECE1 | endothelin converting enzyme 1 | 0.0309844 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0307445 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0307295 |
| ZNF638 | zinc finger protein 638 | 0.0304479 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0304015 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0297786 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0297376 |
| KSR1 | kinase suppressor of ras 1 | 0.0294401 |
| FAM13A | family with sequence similarity 13, member A | 0.0286202 |
| TGFB1 | transforming growth factor, beta 1 | 0.028598 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0280619 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0278114 |
| EZR | ezrin | 0.0277948 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.0272892 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0272095 |
| INTS6 | integrator complex subunit 6 | 0.0272086 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.026757 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.026443 |
| PTK2 | protein tyrosine kinase 2 | 0.026292 |
| PDE8A | phosphodiesterase 8A | 0.0262703 |
| SRP54 | signal recognition particle 54kDa | 0.0257588 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0256753 |
| YBX3 | Y box binding protein 3 | 0.0255848 |
| ATP13A3 | ATPase type 13A3 | 0.0253484 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0253306 |
| CCNL1 | cyclin L1 | 0.0250008 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0247895 |
| MIPOL1 | mirror-image polydactyly 1 | 0.024343 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0242783 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.02395 |
| STK38L | serine/threonine kinase 38 like | 0.0237916 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0236957 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0236418 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.023585 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0234138 |
| SYAP1 | synapse associated protein 1 | 0.0231033 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.023085 |
| RNF145 | ring finger protein 145 | 0.0228061 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0226897 |
| FOXO3 | forkhead box O3 | 0.0223912 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0223612 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0222564 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.022232 |
| MYO1E | myosin IE | 0.0222 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0220004 |
| BRD2 | bromodomain containing 2 | 0.0219127 |
| HELZ | helicase with zinc finger | 0.0219022 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0218205 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0218007 |
| SPAG9 | sperm associated antigen 9 | 0.0216927 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0214746 |
| RARB | retinoic acid receptor, beta | 0.0212931 |
| FAM107B | family with sequence similarity 107, member B | 0.0210994 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0210591 |
| GPHN | gephyrin | 0.0210505 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0207902 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0207526 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0207126 |
| EGFR | epidermal growth factor receptor | 0.0206789 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0206333 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.020572 |
| SKIL | SKI-like proto-oncogene | 0.0203946 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0203547 |
| SEPTIN9 | septin 9 | 0.0203096 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0202504 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0201998 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.020104 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.204011 |
| TMSB10 | thymosin beta 10 | -0.176689 |
| VIM | vimentin | -0.1471 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.143321 |
| CDH13 | cadherin 13 | -0.138733 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.116605 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.111429 |
| HMGA2 | high mobility group AT-hook 2 | -0.103024 |
| DPYD | dihydropyrimidine dehydrogenase | -0.102322 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.102071 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0906771 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0882266 |
| GPC6 | glypican 6 | -0.0859778 |
| MTSS1 | metastasis suppressor 1 | -0.0806057 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0774909 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0767683 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0688572 |
| STC1 | stanniocalcin 1 | -0.0687504 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0659767 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0656333 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0613559 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0597823 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0556402 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0552005 |
| DST | dystonin | -0.0535279 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.052229 |
| RAI14 | retinoic acid induced 14 | -0.0512332 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0494366 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0492182 |
| LOX | lysyl oxidase | -0.0478481 |
| S100A6 | S100 calcium binding protein A6 | -0.0474747 |
| MEF2A | myocyte enhancer factor 2A | -0.0472524 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0463321 |
| OXR1 | oxidation resistance 1 | -0.0454899 |
| CLMP | CXADR-like membrane protein | -0.0445964 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0422383 |
| DIAPH2 | diaphanous-related formin 2 | -0.0421947 |
| OSMR | oncostatin M receptor | -0.0419039 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0413813 |
| AHNAK | AHNAK nucleoprotein | -0.0412565 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0407625 |
| ZNF804A | zinc finger protein 804A | -0.0404737 |
| PTMA | prothymosin, alpha | -0.0398505 |
| NRG1 | neuregulin 1 | -0.0397763 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.039699 |
| CDK14 | cyclin-dependent kinase 14 | -0.039582 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0386745 |
| PRRX1 | paired related homeobox 1 | -0.0371454 |
| MECOM | MDS1 and EVI1 complex locus | -0.0368167 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0367677 |
| TMSB4X | thymosin beta 4, X-linked | -0.0350119 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0339255 |
| CUX1 | cut-like homeobox 1 | -0.0335118 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0334534 |
| TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | -0.0332392 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0329267 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0321552 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0320872 |
| NAV1 | neuron navigator 1 | -0.0319607 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0315013 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0315002 |
| ENOSF1 | enolase superfamily member 1 | -0.0312379 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0306458 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.030609 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0305967 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0303344 |
| CFAP20DC | CFAP20 domain containing | -0.0302338 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0301572 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.0296387 |
| NAV3 | neuron navigator 3 | -0.0296316 |
| TNNC1 | troponin C type 1 (slow) | -0.0294206 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0293743 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0291352 |
| PRSS23 | protease, serine, 23 | -0.029087 |
| ENO1 | enolase 1, (alpha) | -0.0286917 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0284345 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0281869 |
| S100A10 | S100 calcium binding protein A10 | -0.0280951 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0279826 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.027865 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.027384 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.02735 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0271288 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.026744 |
| RASAL2 | RAS protein activator like 2 | -0.0265473 |
| ATG7 | autophagy related 7 | -0.0265379 |
| FTL | ferritin, light polypeptide | -0.0265249 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0264005 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0263937 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0258221 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0257484 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0256685 |
| ABCA6 | ATP-binding cassette, sub-family A (ABC1), member 6 | -0.0252656 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.025168 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0250868 |
| HLA-B | major histocompatibility complex, class I, B | -0.0248509 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0245386 |
| SYT1 | synaptotagmin I | -0.0244748 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0244547 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0244458 |
