| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Relugolix perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Relugolix_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0969385 |
| MT2A | metallothionein 2A | 0.0771908 |
| IER3 | immediate early response 3 | 0.059312 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0567131 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0522333 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.046961 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0392001 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0386113 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0371911 |
| CAVIN1 | caveolae associated protein 1 | 0.0364119 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0350131 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0346724 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0322996 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0315837 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0304342 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.029052 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0287782 |
| RPLP1 | ribosomal protein, large, P1 | 0.028619 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0286021 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0276682 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0276608 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0270226 |
| GOLGA4 | golgin A4 | 0.0263456 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0263127 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.025594 |
| RPL13A | ribosomal protein L13a | 0.0254625 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0253414 |
| RPS29 | ribosomal protein S29 | 0.0250368 |
| LAMC2 | laminin, gamma 2 | 0.0245129 |
| GOLGB1 | golgin B1 | 0.0242743 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0241851 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0234621 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0234574 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0234166 |
| ITSN2 | intersectin 2 | 0.0231834 |
| CYTH1 | cytohesin 1 | 0.0229127 |
| RPL37A | ribosomal protein L37a | 0.0228581 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0227986 |
| RPL31 | ribosomal protein L31 | 0.022791 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0227365 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0226681 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0223869 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0221554 |
| ACTG1 | actin gamma 1 | 0.0221124 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0216794 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 0.0215536 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0215057 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0214416 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0211904 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0210912 |
| HLA-B | major histocompatibility complex, class I, B | 0.0210292 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0207352 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.0206325 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0200441 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0197026 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0196488 |
| RPS3 | ribosomal protein S3 | 0.0196386 |
| RBM25 | RNA binding motif protein 25 | 0.0196068 |
| MYO1E | myosin IE | 0.019414 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0192149 |
| EGFR | epidermal growth factor receptor | 0.0191788 |
| RPL34 | ribosomal protein L34 | 0.0190369 |
| RPL38 | ribosomal protein L38 | 0.018811 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0185021 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0184848 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0184749 |
| APP | amyloid beta (A4) precursor protein | 0.0184015 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0183941 |
| ATXN1 | ataxin 1 | 0.0183074 |
| NUDT21 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | 0.0179905 |
| RPS8 | ribosomal protein S8 | 0.0177282 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0177043 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0175471 |
| B2M | beta-2-microglobulin | 0.0175214 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0175136 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.0175057 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0173448 |
| HLA-C | major histocompatibility complex, class I, C | 0.0173133 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0172971 |
| RBM39 | RNA binding motif protein 39 | 0.0171067 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | 0.0170124 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0169064 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | 0.0168499 |
| RPL23 | ribosomal protein L23 | 0.0166362 |
| CDCP1 | CUB domain containing protein 1 | 0.016635 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0163307 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0162383 |
| COPA | coatomer protein complex, subunit alpha | 0.0162115 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0160508 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0159984 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0157673 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0157304 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0157249 |
| FAM107B | family with sequence similarity 107, member B | 0.015597 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0155647 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.01555 |
| YTHDC1 | YTH domain containing 1 | 0.0155267 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0154856 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.015469 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0154559 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.337475 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.197797 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.130474 |
| VIM | vimentin | -0.117996 |
| FTL | ferritin, light polypeptide | -0.10328 |
| TMSB10 | thymosin beta 10 | -0.078858 |
| TXNRD1 | thioredoxin reductase 1 | -0.078699 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.06993 |
| PFN1 | profilin 1 | -0.0582957 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0541364 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0529124 |
| RPLP0 | ribosomal protein, large, P0 | -0.0517183 |
| HMGA1 | high mobility group AT-hook 1 | -0.0512986 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0484563 |
| FGB | fibrinogen beta chain | -0.0470073 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0462426 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0417585 |
| PKM | pyruvate kinase, muscle | -0.0410957 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0393277 |
| TAGLN2 | transgelin 2 | -0.0388992 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0386557 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0382386 |
| POTEF | POTE ankyrin domain family, member F | -0.0381353 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0375227 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0370321 |
| RTN4 | reticulon 4 | -0.036543 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0355663 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0344857 |
| PM20D1 | peptidase M20 domain containing 1 | -0.034339 |
| S100A6 | S100 calcium binding protein A6 | -0.0341835 |
| PCBP2 | poly(rC) binding protein 2 | -0.0337305 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0337261 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0333583 |
| YBX1 | Y box binding protein 1 | -0.0333133 |
| LDHB | lactate dehydrogenase B | -0.0329786 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0316155 |
| MCL1 | myeloid cell leukemia 1 | -0.030943 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0293628 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0292289 |
| ANXA2 | annexin A2 | -0.0288015 |
| TPM3 | tropomyosin 3 | -0.0283371 |
| LDHA | lactate dehydrogenase A | -0.027051 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0251686 |
| FGG | fibrinogen gamma chain | -0.0249518 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0246528 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0245199 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0242752 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0240525 |
| AHR | aryl hydrocarbon receptor | -0.0240197 |
| RPL19 | ribosomal protein L19 | -0.0236347 |
| ERBIN | erbb2 interacting protein | -0.0235895 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0233415 |
| TMEM123 | transmembrane protein 123 | -0.0229399 |
| RHOA | ras homolog family member A | -0.0226654 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0223745 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0222504 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.022145 |
| PRR16 | proline rich 16 | -0.0219882 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0215676 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.02126 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.021116 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0210957 |
| BMPR1B | bone morphogenetic protein receptor, type IB | -0.0210695 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0210394 |
| PLS3 | plastin 3 | -0.0210051 |
| TPX2 | TPX2, microtubule-associated | -0.0205677 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0205091 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | -0.0202538 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -0.0202015 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0199495 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.0190961 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0190886 |
| CCT2 | chaperonin containing TCP1, subunit 2 (beta) | -0.01876 |
| ACLY | ATP citrate lyase | -0.0187155 |
| SRGN | serglycin | -0.0186827 |
| NFIA | nuclear factor I/A | -0.0186482 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0184993 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0183504 |
| ENAH | enabled homolog (Drosophila) | -0.0183283 |
| ECT2 | epithelial cell transforming 2 | -0.0182278 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0181833 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0180862 |
| UBC | ubiquitin C | -0.0180775 |
| RPS5 | ribosomal protein S5 | -0.0178758 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0178564 |
| TUBB | tubulin, beta class I | -0.0178045 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0177052 |
| MYADM | myeloid-associated differentiation marker | -0.0175167 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0172768 |
| EFNA5 | ephrin-A5 | -0.0172195 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.017208 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | -0.0171118 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.016898 |
| TUBA1B | tubulin, alpha 1b | -0.0168278 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | -0.0165707 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0165684 |
| ASTN2 | astrotactin 2 | -0.0164707 |
| WBP11 | WW domain binding protein 11 | -0.0164334 |
| CHN1 | chimerin 1 | -0.0163571 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0162614 |
