| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Relugolix perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Relugolix_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.115065 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0793965 |
| STC1 | stanniocalcin 1 | 0.0707135 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0676259 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0577516 |
| FN1 | fibronectin 1 | 0.0569871 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0544834 |
| LAMC2 | laminin, gamma 2 | 0.0540239 |
| KYNU | kynureninase | 0.0514123 |
| PRELID2 | PRELI domain containing 2 | 0.0488603 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0463353 |
| HMGA2 | high mobility group AT-hook 2 | 0.045439 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0453572 |
| GOLGA4 | golgin A4 | 0.0449688 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0445348 |
| ASPH | aspartate beta-hydroxylase | 0.0432942 |
| EGFR | epidermal growth factor receptor | 0.0431139 |
| MT2A | metallothionein 2A | 0.0428008 |
| VIM | vimentin | 0.0405887 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0396408 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0393762 |
| AHR | aryl hydrocarbon receptor | 0.0387679 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0377582 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0373019 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0368857 |
| PKM | pyruvate kinase, muscle | 0.0352633 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0350125 |
| MEIS1 | Meis homeobox 1 | 0.0349285 |
| ENO1 | enolase 1, (alpha) | 0.0347331 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0339624 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 0.0336975 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0336101 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0333344 |
| CLTC | clathrin, heavy chain (Hc) | 0.0327636 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0324271 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0323165 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.032164 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0320758 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.031825 |
| RUNX1 | runt-related transcription factor 1 | 0.031134 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.031046 |
| BPTF | bromodomain PHD finger transcription factor | 0.0309927 |
| FMNL2 | formin-like 2 | 0.0300344 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0295811 |
| DTNA | dystrobrevin, alpha | 0.0295247 |
| RPS8 | ribosomal protein S8 | 0.0290559 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0288619 |
| FTL | ferritin, light polypeptide | 0.0288568 |
| ATP13A3 | ATPase type 13A3 | 0.0287602 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0285916 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0285202 |
| COG6 | component of oligomeric golgi complex 6 | 0.0284172 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0283342 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0282063 |
| ZFR | zinc finger RNA binding protein | 0.0280136 |
| BRD2 | bromodomain containing 2 | 0.0278505 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0276413 |
| RPS12 | ribosomal protein S12 | 0.0272286 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0269119 |
| HDLBP | high density lipoprotein binding protein | 0.026852 |
| ATG7 | autophagy related 7 | 0.0267464 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0264673 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0264315 |
| ANXA2 | annexin A2 | 0.0261331 |
| GRAMD2B | GRAM domain containing 2B | 0.0260248 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0259167 |
| STK17A | serine/threonine kinase 17a | 0.0258798 |
| IGF2 | insulin-like growth factor 2 | 0.0258197 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0258058 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0256874 |
| SLC30A9 | solute carrier family 30 (zinc transporter), member 9 | 0.0256128 |
| FRY | furry homolog (Drosophila) | 0.0255312 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0253544 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0253146 |
| WWC2 | WW and C2 domain containing 2 | 0.025156 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0251183 |
| RPS2 | ribosomal protein S2 | 0.0249589 |
| SSH2 | slingshot protein phosphatase 2 | 0.0249061 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0248405 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | 0.0248275 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0247643 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0247541 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0245636 |
| NLGN1 | neuroligin 1 | 0.0244209 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.024389 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0243746 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0242157 |
| AREG | amphiregulin | 0.0239148 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0237753 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0236656 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0236501 |
| ANO6 | anoctamin 6 | 0.0234602 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0234599 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | 0.0233732 |
| STK24 | serine/threonine kinase 24 | 0.0233303 |
| TPM4 | tropomyosin 4 | 0.0231755 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0229558 |
| FLNB | filamin B, beta | 0.0229152 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0226972 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.022692 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GRB10 | growth factor receptor-bound protein 10 | -0.152124 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.135786 |
| ATOSA | atos homolog A | -0.0903897 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0809496 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0789765 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0738916 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0723956 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0622258 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0610071 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.059719 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.056556 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0554203 |
| FDPS | farnesyl diphosphate synthase | -0.0550569 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0507899 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0506709 |
| USP3 | ubiquitin specific peptidase 3 | -0.0489682 |
| KRT17 | keratin 17, type I | -0.0483146 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0479516 |
| MYO6 | myosin VI | -0.0476726 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0475102 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0474066 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0469204 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0464892 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0462296 |
| FAM107B | family with sequence similarity 107, member B | -0.0455665 |
| CDYL | chromodomain protein, Y-like | -0.0448892 |
| MYOF | myoferlin | -0.0438342 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0436018 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0434051 |
| TXNRD1 | thioredoxin reductase 1 | -0.0432342 |
| ATXN2 | ataxin 2 | -0.0421178 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.042116 |
| SVIL | supervillin | -0.0408816 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0408049 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0402279 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.039973 |
| TNPO1 | transportin 1 | -0.0396135 |
| DSG2 | desmoglein 2 | -0.0386761 |
| PARD3 | par-3 family cell polarity regulator | -0.0382413 |
| MUC16 | mucin 16, cell surface associated | -0.0377839 |
| ZNF644 | zinc finger protein 644 | -0.0372975 |
| PTGES2 | prostaglandin E synthase 2 | -0.0372038 |
| ERBIN | erbb2 interacting protein | -0.0366309 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0365254 |
| RIOK3 | RIO kinase 3 | -0.0364387 |
| FOXO3 | forkhead box O3 | -0.0364099 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | -0.0361861 |
| NHSL1 | NHS-like 1 | -0.0356424 |
| S100A8 | S100 calcium binding protein A8 | -0.0351193 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0350524 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0350523 |
| WDR26 | WD repeat domain 26 | -0.0350073 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0347883 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0342759 |
| AHNAK | AHNAK nucleoprotein | -0.0341353 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0336483 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0329014 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0328478 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0327429 |
| ACTN4 | actinin, alpha 4 | -0.0324966 |
| LDLR | low density lipoprotein receptor | -0.0321847 |
| TOP1 | topoisomerase (DNA) I | -0.0321243 |
| NPTN | neuroplastin | -0.0318507 |
| PLAU | plasminogen activator, urokinase | -0.0313883 |
| SNX9 | sorting nexin 9 | -0.031183 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.030923 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.030674 |
| TAOK3 | TAO kinase 3 | -0.0306426 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0304561 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0304109 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0302421 |
| CD2AP | CD2-associated protein | -0.0297985 |
| H3-3B | H3.3 histone B | -0.0294029 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0293685 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0290061 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0288149 |
| NDRG1 | N-myc downstream regulated 1 | -0.0286386 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0285936 |
| GPATCH8 | G patch domain containing 8 | -0.0285842 |
| SRPK2 | SRSF protein kinase 2 | -0.0280689 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0278466 |
| ZNF292 | zinc finger protein 292 | -0.0278262 |
| RPS6 | ribosomal protein S6 | -0.0277815 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.027779 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0276233 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0275739 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0275014 |
| FNBP1L | formin binding protein 1-like | -0.0274693 |
| ABLIM1 | actin binding LIM protein 1 | -0.027446 |
| CPNE8 | copine VIII | -0.0274131 |
| LAMB3 | laminin, beta 3 | -0.0272133 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0269268 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0268844 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0268521 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0266638 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0266549 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0266431 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0264928 |
| THOC2 | THO complex 2 | -0.0262604 |
| FOXP1 | forkhead box P1 | -0.0262425 |
