Relugolix_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Relugolix perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Relugolix_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.341957
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0999781
GRAMD1B GRAM domain containing 1B 0.0691894
ERRFI1 ERBB receptor feedback inhibitor 1 0.0667572
THSD4 thrombospondin, type I, domain containing 4 0.0640207
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0612763
PDE10A phosphodiesterase 10A 0.0592605
OSMR oncostatin M receptor 0.0590079
AFF3 AF4/FMR2 family, member 3 0.0544664
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0539454
PDE4D phosphodiesterase 4D, cAMP-specific 0.0492765
MACF1 microtubule-actin crosslinking factor 1 0.0460753
PYGL phosphorylase, glycogen, liver 0.0453146
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.043825
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0436225
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0389806
COPA coatomer protein complex, subunit alpha 0.037818
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0374952
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0360964
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0357319
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.03508
ZCCHC7 zinc finger, CCHC domain containing 7 0.0349414
MCL1 myeloid cell leukemia 1 0.0341504
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.033739
ATXN1 ataxin 1 0.0326686
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0326225
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0323256
FMNL2 formin-like 2 0.0322815
FNDC3B fibronectin type III domain containing 3B 0.0319039
DOCK5 dedicator of cytokinesis 5 0.0318124
TAS2R14 taste receptor, type 2, member 14 0.0316313
PTK2 protein tyrosine kinase 2 0.0308648
VMP1 vacuole membrane protein 1 0.030037
RABGAP1L RAB GTPase activating protein 1-like 0.0298572
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0298273
EGFR epidermal growth factor receptor 0.0298269
HMGA2 high mobility group AT-hook 2 0.0296742
EPAS1 endothelial PAS domain protein 1 0.0291513
ANO6 anoctamin 6 0.0289701
VCL vinculin 0.0289029
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0276672
EML4 echinoderm microtubule associated protein like 4 0.0276491
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0275949
LPP LIM domain containing preferred translocation partner in lipoma 0.0266017
EXT1 exostosin glycosyltransferase 1 0.0258599
ATP13A3 ATPase type 13A3 0.0257681
DENND5B DENN/MADD domain containing 5B 0.0249514
ACTN1 actinin, alpha 1 0.0248571
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0246215
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0237579
CAMTA1 calmodulin binding transcription activator 1 0.0231194
DOCK1 dedicator of cytokinesis 1 0.0230725
TMEM41B transmembrane protein 41B 0.0229297
IGF1R insulin-like growth factor 1 receptor 0.0228323
YAP1 Yes-associated protein 1 0.0227941
CDCP1 CUB domain containing protein 1 0.0224584
PATJ PATJ crumbs cell polarity complex component 0.0222717
AKAP9 A kinase (PRKA) anchor protein 9 0.0221079
RAD51B RAD51 paralog B 0.0221016
PRKCE protein kinase C, epsilon 0.0218621
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0214034
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0212267
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.021213
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0211471
RICTOR RPTOR independent companion of MTOR, complex 2 0.0211335
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0211173
LOXL2 lysyl oxidase-like 2 0.0208954
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0205958
BMAL2 basic helix-loop-helix ARNT like 2 0.0205618
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0200665
SVIL supervillin 0.0199436
DIAPH2 diaphanous-related formin 2 0.0198941
WWTR1 WW domain containing transcription regulator 1 0.019844
CUX1 cut-like homeobox 1 0.0198379
RIMS2 regulating synaptic membrane exocytosis 2 0.0195358
MMP12 matrix metallopeptidase 12 0.0194251
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0194067
DSPP dentin sialophosphoprotein 0.0194017
R3HDM2 R3H domain containing 2 0.0193816
PDLIM5 PDZ and LIM domain 5 0.0193704
FAF1 Fas (TNFRSF6) associated factor 1 0.019335
NF1 neurofibromin 1 0.019303
CDK17 cyclin-dependent kinase 17 0.019259
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0192008
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0191933
CAPRIN2 caprin family member 2 0.0190875
DPYSL2 dihydropyrimidinase-like 2 0.0190205
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0188147
RYR3 ryanodine receptor 3 0.0187588
ETV6 ets variant 6 0.0186871
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0184589
ATG7 autophagy related 7 0.0182408
COL5A2 collagen, type V, alpha 2 0.0182021
TPM4 tropomyosin 4 0.0181537
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0180456
CHIC2 cysteine-rich hydrophobic domain 2 0.0180014
SOS2 son of sevenless homolog 2 (Drosophila) 0.0179001
ANKRD11 ankyrin repeat domain 11 0.0177957
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0176096
SENP6 SUMO1/sentrin specific peptidase 6 0.0175386

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.345486
TFPI2 tissue factor pathway inhibitor 2 -0.128853
VIM vimentin -0.11585
TMSB10 thymosin beta 10 -0.112762
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0999989
PTMA prothymosin, alpha -0.0853644
TPI1 triosephosphate isomerase 1 -0.0789916
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0667448
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0603851
RPS21 ribosomal protein S21 -0.0569645
RPL12 ribosomal protein L12 -0.0547071
RPLP0 ribosomal protein, large, P0 -0.0527704
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0512822
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0501831
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.049434
RPS8 ribosomal protein S8 -0.0483202
PFN1 profilin 1 -0.0468678
MYL12B myosin, light chain 12B, regulatory -0.0465733
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0455279
RPL23 ribosomal protein L23 -0.0452298
NAP1L1 nucleosome assembly protein 1-like 1 -0.0442142
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0412506
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0403911
MT2A metallothionein 2A -0.0384883
RPL32 ribosomal protein L32 -0.0382256
SMC4 structural maintenance of chromosomes 4 -0.0375595
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0372884
RPL35A ribosomal protein L35a -0.0369886
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0365323
RPL19 ribosomal protein L19 -0.0364622
LDHB lactate dehydrogenase B -0.0346572
RPL37 ribosomal protein L37 -0.0345405
RPLP1 ribosomal protein, large, P1 -0.0338724
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0333258
CBX3 chromobox homolog 3 -0.0326728
RPL11 ribosomal protein L11 -0.0323331
RPL8 ribosomal protein L8 -0.0320956
EGR1 early growth response 1 -0.032093
PHIP pleckstrin homology domain interacting protein -0.0317779
RPS4X ribosomal protein S4, X-linked -0.0311517
TXNRD1 thioredoxin reductase 1 -0.0307785
TPT1 tumor protein, translationally-controlled 1 -0.0305451
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0304727
ATP5F1B ATP synthase F1 subunit beta -0.0301848
ATP5F1E ATP synthase F1 subunit epsilon -0.0300159
RPL26 ribosomal protein L26 -0.0297198
CENPF centromere protein F, 350/400kDa -0.0289317
SEPTIN7 septin 7 -0.0288001
RPS15 ribosomal protein S15 -0.0287075
RPS27A ribosomal protein S27a -0.0284334
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0282267
RPS19 ribosomal protein S19 -0.0279933
RPS3 ribosomal protein S3 -0.0276913
RPS29 ribosomal protein S29 -0.0276803
MIS18BP1 MIS18 binding protein 1 -0.0269742
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0269063
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0267364
RACK1 receptor for activated C kinase 1 -0.0263675
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0263216
EIF1 eukaryotic translation initiation factor 1 -0.0261148
YBX1 Y box binding protein 1 -0.0260709
RPS12 ribosomal protein S12 -0.0260041
RPLP2 ribosomal protein, large, P2 -0.0259506
RPL34 ribosomal protein L34 -0.025904
ACTG1 actin gamma 1 -0.0258064
VDAC1 voltage-dependent anion channel 1 -0.0257644
HMGA1 high mobility group AT-hook 1 -0.0254442
GNAS GNAS complex locus -0.0251846
GSTP1 glutathione S-transferase pi 1 -0.0251132
TRIO trio Rho guanine nucleotide exchange factor -0.0242583
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0238766
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0238319
TUBA1B tubulin, alpha 1b -0.0235351
DEK DEK proto-oncogene -0.0234087
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0233828
RPL5 ribosomal protein L5 -0.0232021
RPL31 ribosomal protein L31 -0.0226239
RPS14 ribosomal protein S14 -0.0225652
RRM2 ribonucleotide reductase M2 -0.0225007
NIPBL Nipped-B homolog (Drosophila) -0.022206
RPL35 ribosomal protein L35 -0.0218191
CENPE centromere protein E, 312kDa -0.0217265
YBX3 Y box binding protein 3 -0.0216037
SRP72 signal recognition particle 72kDa -0.0215033
DIAPH3 diaphanous-related formin 3 -0.0214917
SGO2 shugoshin 2 -0.0213845
WBP11 WW domain binding protein 11 -0.0213513
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0212617
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.0212392
UBB ubiquitin B -0.0210397
RPS20 ribosomal protein S20 -0.0210288
BSG basigin (Ok blood group) -0.0209958
MKI67 marker of proliferation Ki-67 -0.0209896
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0209053
OAZ1 ornithine decarboxylase antizyme 1 -0.0208545
SSB Sjogren syndrome antigen B (autoantigen La) -0.0208198
SON SON DNA binding protein -0.0206508
RPL9 ribosomal protein L9 -0.0205016
RPS6 ribosomal protein S6 -0.0204856
TAGLN2 transgelin 2 -0.0204037