| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Relugolix perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Relugolix_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.239791 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.182865 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.151128 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.144472 |
| LAMC2 | laminin, gamma 2 | 0.131921 |
| ASPH | aspartate beta-hydroxylase | 0.10699 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0984674 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0926607 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0738699 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0716371 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0663257 |
| NDRG1 | N-myc downstream regulated 1 | 0.0659005 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0658731 |
| ARRDC3 | arrestin domain containing 3 | 0.0650603 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0628332 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0596791 |
| CTSB | cathepsin B | 0.0586873 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0542222 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.052652 |
| LDHA | lactate dehydrogenase A | 0.052531 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0523767 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0522076 |
| RPS12 | ribosomal protein S12 | 0.0515768 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0514602 |
| RACK1 | receptor for activated C kinase 1 | 0.0513686 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0511868 |
| LMO7 | LIM domain 7 | 0.0507815 |
| DSPP | dentin sialophosphoprotein | 0.0498327 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0491099 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0485741 |
| MSN | moesin | 0.0479727 |
| CALR | calreticulin | 0.0467408 |
| RPS2 | ribosomal protein S2 | 0.04637 |
| UPP1 | uridine phosphorylase 1 | 0.0463395 |
| UBC | ubiquitin C | 0.0461776 |
| KRT8 | keratin 8, type II | 0.0461111 |
| RPS3 | ribosomal protein S3 | 0.0447204 |
| POTEF | POTE ankyrin domain family, member F | 0.0444379 |
| TPM3 | tropomyosin 3 | 0.0436001 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0432124 |
| MYO5B | myosin VB | 0.0418169 |
| ANXA1 | annexin A1 | 0.0408192 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0392114 |
| NR3C2 | nuclear receptor subfamily 3, group C, member 2 | 0.0391461 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0390326 |
| ENO1 | enolase 1, (alpha) | 0.0386333 |
| MKI67 | marker of proliferation Ki-67 | 0.0383525 |
| CCNL1 | cyclin L1 | 0.037832 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.03735 |
| NCKAP1 | NCK-associated protein 1 | 0.0372657 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0372214 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0372008 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.036929 |
| RPL4 | ribosomal protein L4 | 0.0367309 |
| RPL3 | ribosomal protein L3 | 0.0363364 |
| ANXA5 | annexin A5 | 0.0359258 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0357931 |
| TXNIP | thioredoxin interacting protein | 0.03421 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0339256 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0333298 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0332252 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.033049 |
| DSG2 | desmoglein 2 | 0.0327266 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0320022 |
| ANXA2 | annexin A2 | 0.0312627 |
| IL6ST | interleukin 6 signal transducer | 0.0309128 |
| PGK1 | phosphoglycerate kinase 1 | 0.0307617 |
| IRF6 | interferon regulatory factor 6 | 0.0302699 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0298608 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0296528 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0296068 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0293164 |
| PLEC | plectin | 0.0290984 |
| APP | amyloid beta (A4) precursor protein | 0.0290679 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0286306 |
| VEGFA | vascular endothelial growth factor A | 0.028523 |
| CPNE8 | copine VIII | 0.0282337 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0280836 |
| RAB27B | RAB27B, member RAS oncogene family | 0.027598 |
| LTA4H | leukotriene A4 hydrolase | 0.0275926 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0275739 |
| DST | dystonin | 0.0273964 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0266939 |
| CD44 | CD44 molecule (Indian blood group) | 0.0265508 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0263837 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0261218 |
| KRT7 | keratin 7, type II | 0.0260237 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.025808 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.025717 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.02563 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0253404 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0251151 |
| EGFR | epidermal growth factor receptor | 0.024945 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0248143 |
| DUSP10 | dual specificity phosphatase 10 | 0.0247188 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0246629 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0246 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0243021 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.024139 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0241359 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.171328 |
| TMSB10 | thymosin beta 10 | -0.157277 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0859434 |
| FTL | ferritin, light polypeptide | -0.08077 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0719808 |
| RRBP1 | ribosome binding protein 1 | -0.0599328 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0589634 |
| RPL35A | ribosomal protein L35a | -0.0578373 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0573666 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0554629 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0527026 |
| GOLGA4 | golgin A4 | -0.0522182 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0517911 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0509488 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0503351 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0500815 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0500246 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.048141 |
| RBM39 | RNA binding motif protein 39 | -0.0475502 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0464267 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0448117 |
| TMEM263 | transmembrane protein 263 | -0.0445358 |
| GNAS | GNAS complex locus | -0.0442578 |
| SEC24D | SEC24 family member D | -0.0434811 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0430914 |
| FBXO32 | F-box protein 32 | -0.0421981 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0415568 |
| HLA-B | major histocompatibility complex, class I, B | -0.0395014 |
| LMNA | lamin A/C | -0.0394727 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0391722 |
| RBM25 | RNA binding motif protein 25 | -0.0380745 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0379058 |
| FBXO34 | F-box protein 34 | -0.0373539 |
| MYO1E | myosin IE | -0.0371986 |
| FBXO11 | F-box protein 11 | -0.0370053 |
| RCOR1 | REST corepressor 1 | -0.0368921 |
| S100A6 | S100 calcium binding protein A6 | -0.0362331 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0359929 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.035936 |
| GOLGB1 | golgin B1 | -0.0357865 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0357768 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0355541 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0350208 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0348878 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.034396 |
| SRP54 | signal recognition particle 54kDa | -0.0339817 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0332317 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.032758 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0325324 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0318169 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0317347 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0315829 |
| YY1 | YY1 transcription factor | -0.031571 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0315262 |
| CSTB | cystatin B (stefin B) | -0.0311705 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0308082 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.030334 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0301771 |
| INTS6 | integrator complex subunit 6 | -0.0295375 |
| CTBP2 | C-terminal binding protein 2 | -0.0295188 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0294258 |
| TOP1 | topoisomerase (DNA) I | -0.0291228 |
| PRRC2C | proline-rich coiled-coil 2C | -0.02899 |
| SP100 | SP100 nuclear antigen | -0.0288443 |
| FLNB | filamin B, beta | -0.0288406 |
| CCND1 | cyclin D1 | -0.0287551 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0283227 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.0279522 |
| WASF2 | WAS protein family, member 2 | -0.027765 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.027694 |
| RPS29 | ribosomal protein S29 | -0.0274437 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0274269 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0266974 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0265994 |
| NEMF | nuclear export mediator factor | -0.0261761 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0259824 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0258393 |
| RPL34 | ribosomal protein L34 | -0.0258032 |
| MSI2 | musashi RNA-binding protein 2 | -0.0256652 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0254028 |
| TPM4 | tropomyosin 4 | -0.0253494 |
| FNIP1 | folliculin interacting protein 1 | -0.0253051 |
| CEP350 | centrosomal protein 350kDa | -0.0252344 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0252096 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0251946 |
| SCFD1 | sec1 family domain containing 1 | -0.0251252 |
| S100A9 | S100 calcium binding protein A9 | -0.0250444 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0250428 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0249697 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0247936 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0245521 |
| CALU | calumenin | -0.0244199 |
| TMEM165 | transmembrane protein 165 | -0.0243297 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.024326 |
| RAI14 | retinoic acid induced 14 | -0.0242386 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0242123 |
| MX2 | MX dynamin-like GTPase 2 | -0.023913 |
| COG5 | component of oligomeric golgi complex 5 | -0.0238811 |
| RPS19 | ribosomal protein S19 | -0.023738 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0237313 |
