| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Relugolix perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Relugolix_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.246048 |
| PM20D1 | peptidase M20 domain containing 1 | 0.197503 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.121476 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.105767 |
| KYNU | kynureninase | 0.100256 |
| SPAG9 | sperm associated antigen 9 | 0.0862619 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0825033 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0810877 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0757305 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0693382 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0693102 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0614423 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.061039 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0582287 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0577163 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0565125 |
| INTS6 | integrator complex subunit 6 | 0.0541633 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0539961 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0536602 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0533742 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0524498 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0493675 |
| EZR | ezrin | 0.0478307 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0469025 |
| PDE10A | phosphodiesterase 10A | 0.046775 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0467144 |
| SMAD2 | SMAD family member 2 | 0.0454791 |
| CTBP2 | C-terminal binding protein 2 | 0.0451029 |
| COPA | coatomer protein complex, subunit alpha | 0.0448517 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0431352 |
| NUP58 | nucleoporin 58 | 0.0429567 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.042684 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0426494 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0426023 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0421821 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0419226 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0415462 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0412563 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0395516 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0392669 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0385828 |
| SQSTM1 | sequestosome 1 | 0.038502 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0384475 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0370813 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0369119 |
| EPHA4 | EPH receptor A4 | 0.0364315 |
| VCL | vinculin | 0.0364207 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0355425 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0352161 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0346879 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0341978 |
| MAP7 | microtubule-associated protein 7 | 0.0334228 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0333237 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | 0.0323923 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.032006 |
| MORF4L2 | mortality factor 4 like 2 | 0.0318278 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0312802 |
| FMNL2 | formin-like 2 | 0.031036 |
| OXSR1 | oxidative stress responsive 1 | 0.0310354 |
| PCBP2 | poly(rC) binding protein 2 | 0.0306318 |
| EGR1 | early growth response 1 | 0.0301037 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0300098 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0299988 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0298198 |
| DNER | delta/notch-like EGF repeat containing | 0.0293085 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.02928 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0290812 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0290689 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0290144 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0289726 |
| TOP1 | topoisomerase (DNA) I | 0.0286628 |
| RNF145 | ring finger protein 145 | 0.0286039 |
| HELZ | helicase with zinc finger | 0.0284339 |
| CALR | calreticulin | 0.0282228 |
| UBC | ubiquitin C | 0.0273333 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0272381 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0271671 |
| FBXO11 | F-box protein 11 | 0.027123 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0270643 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0266686 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.026336 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0261011 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0260216 |
| HYOU1 | hypoxia up-regulated 1 | 0.0259881 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0257873 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0255348 |
| ZNF638 | zinc finger protein 638 | 0.0254131 |
| IRS2 | insulin receptor substrate 2 | 0.0251465 |
| BMP6 | bone morphogenetic protein 6 | 0.0250474 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0249132 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0248555 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0248403 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.024767 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.024573 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0241095 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.023938 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0239365 |
| ABLIM1 | actin binding LIM protein 1 | 0.0233933 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0233037 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0231962 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EFNA5 | ephrin-A5 | -0.163462 |
| GDA | guanine deaminase | -0.100579 |
| VIM | vimentin | -0.0770887 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0749002 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0741998 |
| TXNRD1 | thioredoxin reductase 1 | -0.0718357 |
| NRCAM | neuronal cell adhesion molecule | -0.063 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0629348 |
| RPS6 | ribosomal protein S6 | -0.0607359 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0574879 |
| MFF | mitochondrial fission factor | -0.0569083 |
| RPS2 | ribosomal protein S2 | -0.0493389 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0486785 |
| SRGN | serglycin | -0.0485353 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0483286 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.04747 |
| RPL37A | ribosomal protein L37a | -0.0474378 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0472046 |
| RPL26 | ribosomal protein L26 | -0.0468607 |
| RPS8 | ribosomal protein S8 | -0.046844 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0464936 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0460536 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0443156 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0442276 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0425845 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0422501 |
| RPL9 | ribosomal protein L9 | -0.0417331 |
| RPL31 | ribosomal protein L31 | -0.0401995 |
| RPS24 | ribosomal protein S24 | -0.0399961 |
| PCBP3 | poly(rC) binding protein 3 | -0.0399257 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0393892 |
| PYGL | phosphorylase, glycogen, liver | -0.0391822 |
| RPS12 | ribosomal protein S12 | -0.0388864 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0388763 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0388226 |
| FN1 | fibronectin 1 | -0.0382558 |
| RPS13 | ribosomal protein S13 | -0.0378835 |
| PTGR1 | prostaglandin reductase 1 | -0.037164 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0371594 |
| RPS23 | ribosomal protein S23 | -0.0366797 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0363434 |
| RGS2 | regulator of G-protein signaling 2 | -0.03601 |
| TNPO1 | transportin 1 | -0.0352182 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0345627 |
| LAMB1 | laminin, beta 1 | -0.0342218 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0338929 |
| AUTS2 | autism susceptibility candidate 2 | -0.0331357 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0323021 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0320523 |
| RPL36A | ribosomal protein L36a | -0.031949 |
| DPYD | dihydropyrimidine dehydrogenase | -0.031568 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0304621 |
| RPL19 | ribosomal protein L19 | -0.0301542 |
| PTMA | prothymosin, alpha | -0.0301163 |
| RPL12 | ribosomal protein L12 | -0.0297865 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0289195 |
| OSMR | oncostatin M receptor | -0.0287705 |
| RPL37 | ribosomal protein L37 | -0.0284348 |
| NEK7 | NIMA-related kinase 7 | -0.0283183 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0280466 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0274214 |
| CTSC | cathepsin C | -0.0273273 |
| RPS29 | ribosomal protein S29 | -0.0271048 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0270746 |
| GLIS3 | GLIS family zinc finger 3 | -0.0270106 |
| TBXT | T-box transcription factor T | -0.0268929 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.0267205 |
| CTSL | cathepsin L | -0.0265751 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0259263 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0257844 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0256653 |
| PGK1 | phosphoglycerate kinase 1 | -0.0253624 |
| TXNIP | thioredoxin interacting protein | -0.0253255 |
| MT2A | metallothionein 2A | -0.025047 |
| SLC16A6 | solute carrier family 16, member 6 | -0.0248202 |
| RPS21 | ribosomal protein S21 | -0.0247794 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0247188 |
| RPS25 | ribosomal protein S25 | -0.0246325 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.024162 |
| CD109 | CD109 molecule | -0.0239475 |
| RPS3 | ribosomal protein S3 | -0.0239206 |
| SLFN5 | schlafen family member 5 | -0.0236937 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0235469 |
| TENM3 | teneurin transmembrane protein 3 | -0.0234835 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | -0.0230678 |
| BMERB1 | bMERB domain containing 1 | -0.0230444 |
| UBXN4 | UBX domain protein 4 | -0.0226364 |
| DISP1 | dispatched homolog 1 (Drosophila) | -0.0225467 |
| RPL7 | ribosomal protein L7 | -0.0222655 |
| ASPH | aspartate beta-hydroxylase | -0.0221943 |
| SEPTIN10 | septin 10 | -0.0221047 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0220795 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0219461 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0217896 |
| LIN7A | lin-7 homolog A (C. elegans) | -0.0216988 |
| CENPF | centromere protein F, 350/400kDa | -0.0213623 |
| RPL11 | ribosomal protein L11 | -0.0212879 |
| RPL23 | ribosomal protein L23 | -0.0210746 |
| FOXC1 | forkhead box C1 | -0.0209397 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0208968 |
