Relugolix_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Relugolix perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

146 genes differentially expressed following the Relugolix_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.175418
IGFBP3 insulin-like growth factor binding protein 3 0.158185
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.157655
EXT1 exostosin glycosyltransferase 1 0.152764
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.151517
BAIAP2L1 BAI1-associated protein 2-like 1 0.138855
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.126888
HDLBP high density lipoprotein binding protein 0.108086
PGK1 phosphoglycerate kinase 1 0.106915
PTK2 protein tyrosine kinase 2 0.104535
SRRM2 serine/arginine repetitive matrix 2 0.104189
NDRG1 N-myc downstream regulated 1 0.102982
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.10177
THSD4 thrombospondin, type I, domain containing 4 0.0975137
LAMB3 laminin, beta 3 0.0971276
ASPH aspartate beta-hydroxylase 0.0958404
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.094976
HMGA2 high mobility group AT-hook 2 0.0938995
LOC112694756 uncharaterized LOC112694756 0.092945
EPS8 epidermal growth factor receptor pathway substrate 8 0.089295
PLAUR plasminogen activator, urokinase receptor 0.0888411
VCL vinculin 0.0878115
FBXO11 F-box protein 11 0.0874183
CUX1 cut-like homeobox 1 0.0828468
NCOA3 nuclear receptor coactivator 3 0.0774991
LAMC2 laminin, gamma 2 0.0747299
LDHA lactate dehydrogenase A 0.0715516
CANX calnexin 0.0712277
AKAP12 A kinase (PRKA) anchor protein 12 0.0708696
RAB1A RAB1A, member RAS oncogene family 0.0704965
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0701057
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0694274
ANKRD11 ankyrin repeat domain 11 0.0653368
TM9SF3 transmembrane 9 superfamily member 3 0.0616905
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0616891
SOD2 superoxide dismutase 2, mitochondrial 0.0552409
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0543534
PDE4D phosphodiesterase 4D, cAMP-specific 0.050814
PTPRK protein tyrosine phosphatase, receptor type, K 0.0505741
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0500479
FTL ferritin, light polypeptide 0.044404
DSPP dentin sialophosphoprotein 0.0433415
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0415813
AKAP9 A kinase (PRKA) anchor protein 9 0.0412762
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0393227
LRP1B low density lipoprotein receptor-related protein 1B 0.0370061
GOLGB1 golgin B1 0.0350589
ZCCHC7 zinc finger, CCHC domain containing 7 0.0345111
EEF2 eukaryotic translation elongation factor 2 0.0337712
KMT2C lysine (K)-specific methyltransferase 2C 0.033527
ACTG1 actin gamma 1 0.0332647
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0330862
FMN1 formin 1 0.0324285
STC1 stanniocalcin 1 0.0298105
KIF1B kinesin family member 1B 0.0294064
ENO1 enolase 1, (alpha) 0.027785
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0242383
MED13L mediator complex subunit 13-like 0.0239795
FTH1 ferritin, heavy polypeptide 1 0.0238464
HLA-B major histocompatibility complex, class I, B 0.0223022
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0216874
BIRC3 baculoviral IAP repeat containing 3 0.0202153
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0200069
LOC102724023 ES1 protein homolog, mitochondrial 0.0197025
MACF1 microtubule-actin crosslinking factor 1 0.0154438
NIBAN1 niban apoptosis regulator 1 0.0153017
POTEF POTE ankyrin domain family, member F 0.0139774
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0135576
JMJD1C jumonji domain containing 1C 0.0131662
ERRFI1 ERBB receptor feedback inhibitor 1 0.0120557
ELL2 elongation factor, RNA polymerase II, 2 0.0117622
SPAG9 sperm associated antigen 9 0.0104288
EIF1 eukaryotic translation initiation factor 1 0.0100913
RBM25 RNA binding motif protein 25 0.00858637
USP34 ubiquitin specific peptidase 34 0.00811656
GRAMD1B GRAM domain containing 1B 0.00759557
PDE10A phosphodiesterase 10A 0.00667351
LMBR1 limb development membrane protein 1 0.00621172
DSCAM Down syndrome cell adhesion molecule 0.0061238
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.00521834
PKM pyruvate kinase, muscle 0.0047519
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00456336
ATP13A3 ATPase type 13A3 0.00156598
LAMA4 laminin, alpha 4 9.38453E-4

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.237212
PTMA prothymosin, alpha -0.197524
RPS6 ribosomal protein S6 -0.147947
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.135727
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.133465
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.132956
CXCL8 chemokine (C-X-C motif) ligand 8 -0.127353
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.123519
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.11455
ITGA6 integrin, alpha 6 -0.104937
MT2A metallothionein 2A -0.101748
TMSB10 thymosin beta 10 -0.099411
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0994103
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0973612
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0948719
RPS3 ribosomal protein S3 -0.0907712
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0900655
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0886698
ANKRD12 ankyrin repeat domain 12 -0.0883265
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.086672
VIM vimentin -0.0847484
SBF2 SET binding factor 2 -0.0830591
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0766612
KTN1 kinectin 1 (kinesin receptor) -0.0762881
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0745958
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0741168
NKD1 naked cuticle homolog 1 (Drosophila) -0.0728201
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0698725
SLC38A1 solute carrier family 38, member 1 -0.0696272
RPS8 ribosomal protein S8 -0.0678087
RBM39 RNA binding motif protein 39 -0.0662785
TPT1 tumor protein, translationally-controlled 1 -0.0534516
B2M beta-2-microglobulin -0.053059
RPLP1 ribosomal protein, large, P1 -0.0530532
PRRC2C proline-rich coiled-coil 2C -0.0474183
TPM4 tropomyosin 4 -0.046552
LPP LIM domain containing preferred translocation partner in lipoma -0.0443766
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0362781
EFNA5 ephrin-A5 -0.0358442
RAB7A RAB7A, member RAS oncogene family -0.0356856
YBX3 Y box binding protein 3 -0.0342802
ANXA2 annexin A2 -0.032166
SEC31A SEC31 homolog A (S. cerevisiae) -0.0316644
CD44 CD44 molecule (Indian blood group) -0.031
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0300046
CEMIP cell migration inducing protein, hyaluronan binding -0.0299817
PRKCA protein kinase C, alpha -0.0270512
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0253817
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0181161
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0172671
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0170755
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0161893
SLTM SAFB-like, transcription modulator -0.0149299
FNDC3B fibronectin type III domain containing 3B -0.0126772
EGFR epidermal growth factor receptor -0.0117836
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.00652002
USP3 ubiquitin specific peptidase 3 -0.00637861
BACE2 beta-site APP-cleaving enzyme 2 -0.00449959
TRIO trio Rho guanine nucleotide exchange factor -0.00390534
LMO7 LIM domain 7 -0.0034219
MYO1E myosin IE -6.07371E-4
MYO6 myosin VI -1.11097E-5