| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Relugolix perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Relugolix_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PCLO | piccolo presynaptic cytomatrix protein | 0.102452 |
| COL11A1 | collagen, type XI, alpha 1 | 0.101094 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0637179 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0569147 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0539553 |
| FOXP2 | forkhead box P2 | 0.0456764 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0451061 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0432051 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0421156 |
| CALR | calreticulin | 0.0413905 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0401234 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0376165 |
| GASK1B | golgi associated kinase 1B | 0.0346359 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0345449 |
| PEG10 | paternally expressed 10 | 0.0342504 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0340394 |
| TMSB4X | thymosin beta 4, X-linked | 0.0329862 |
| TXNRD1 | thioredoxin reductase 1 | 0.032814 |
| ZC3H13 | zinc finger CCCH-type containing 13 | 0.032576 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | 0.0308776 |
| SHROOM3 | shroom family member 3 | 0.0305349 |
| CADM2 | cell adhesion molecule 2 | 0.0301926 |
| GOLIM4 | golgi integral membrane protein 4 | 0.030136 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0300497 |
| PDGFC | platelet derived growth factor C | 0.0297923 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0295126 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0293171 |
| RAD51B | RAD51 paralog B | 0.0291433 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.0287222 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0280447 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0270491 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0260037 |
| PCDH18 | protocadherin 18 | 0.0256883 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0253833 |
| DMD | dystrophin | 0.0248982 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0248453 |
| METAP2 | methionyl aminopeptidase 2 | 0.0247265 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0247127 |
| SMYD3 | SET and MYND domain containing 3 | 0.0246862 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 0.0244265 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0244106 |
| PCDH11Y | protocadherin 11 Y-linked | 0.0243087 |
| ARHGAP15 | Rho GTPase activating protein 15 | 0.0241667 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.02379 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0237659 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.0236522 |
| RPS2 | ribosomal protein S2 | 0.0235252 |
| NCKAP1 | NCK-associated protein 1 | 0.0233582 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0231901 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0231791 |
| EXOC6B | exocyst complex component 6B | 0.0231355 |
| DACH1 | dachshund family transcription factor 1 | 0.0230745 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0229299 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | 0.0222245 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0215203 |
| PHF3 | PHD finger protein 3 | 0.021445 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0210839 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0208761 |
| TENM3 | teneurin transmembrane protein 3 | 0.0206997 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0206549 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0205913 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0202147 |
| SSR1 | signal sequence receptor, alpha | 0.0201547 |
| HYOU1 | hypoxia up-regulated 1 | 0.0200607 |
| NTM | neurotrimin | 0.0200428 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0197668 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0197617 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0197087 |
| CDH19 | cadherin 19, type 2 | 0.0194531 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0188373 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0188361 |
| ENO1 | enolase 1, (alpha) | 0.0188043 |
| PCDH7 | protocadherin 7 | 0.0186751 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0185941 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0185621 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.018494 |
| NRDC | nardilysin convertase | 0.0184447 |
| USP25 | ubiquitin specific peptidase 25 | 0.0183897 |
| ANLN | anillin, actin binding protein | 0.0183681 |
| UTRN | utrophin | 0.0181836 |
| NBEA | neurobeachin | 0.0181755 |
| CCNY | cyclin Y | 0.0180833 |
| GLI3 | GLI family zinc finger 3 | 0.0178221 |
| KIF1B | kinesin family member 1B | 0.0177961 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.017671 |
| DYNC2H1 | dynein, cytoplasmic 2, heavy chain 1 | 0.0174804 |
| SSH2 | slingshot protein phosphatase 2 | 0.0174573 |
| TAOK3 | TAO kinase 3 | 0.0174166 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0173572 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0173424 |
| TBC1D12 | TBC1 domain family, member 12 | 0.0173421 |
| EFCAB14 | EF-hand calcium binding domain 14 | 0.017188 |
| SMAD4 | SMAD family member 4 | 0.0171817 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0171723 |
| ZZEF1 | zinc finger, ZZ-type with EF-hand domain 1 | 0.0171586 |
| CCDC14 | coiled-coil domain containing 14 | 0.0171446 |
| IPO9 | importin 9 | 0.0170965 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0170622 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0170394 |
| CALCR | calcitonin receptor | 0.0170307 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.244347 |
| TMSB10 | thymosin beta 10 | -0.227173 |
| RPS6 | ribosomal protein S6 | -0.136816 |
| PTMA | prothymosin, alpha | -0.125701 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.115518 |
| RPS16 | ribosomal protein S16 | -0.0939837 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0934762 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0912426 |
| RPS8 | ribosomal protein S8 | -0.09107 |
| RPL35A | ribosomal protein L35a | -0.0905542 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.083901 |
| RPL11 | ribosomal protein L11 | -0.0831683 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0797115 |
| GNAS | GNAS complex locus | -0.076874 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0684861 |
| COL1A2 | collagen, type I, alpha 2 | -0.0666473 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0650168 |
| RPLP1 | ribosomal protein, large, P1 | -0.0632389 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0626303 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0611642 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0605365 |
| PHIP | pleckstrin homology domain interacting protein | -0.0584209 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0538557 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0530845 |
| RPL19 | ribosomal protein L19 | -0.0515233 |
| RPL23 | ribosomal protein L23 | -0.0496597 |
| RIGI | RNA sensor RIG-I | -0.0489347 |
| RPS25 | ribosomal protein S25 | -0.0486467 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0485123 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0480462 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0480257 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0480114 |
| S100A9 | S100 calcium binding protein A9 | -0.0479686 |
| RBM25 | RNA binding motif protein 25 | -0.0473808 |
| RPL9 | ribosomal protein L9 | -0.0456153 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0455838 |
| RPL31 | ribosomal protein L31 | -0.0453927 |
| RPL5 | ribosomal protein L5 | -0.0452891 |
| RPS19 | ribosomal protein S19 | -0.0442997 |
| RPLP2 | ribosomal protein, large, P2 | -0.0442251 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0441054 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0440442 |
| CBX3 | chromobox homolog 3 | -0.0440174 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0434244 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0430844 |
| ITGAV | integrin, alpha V | -0.0427072 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.0422996 |
| B2M | beta-2-microglobulin | -0.0420422 |
| PFN1 | profilin 1 | -0.0419197 |
| S100A10 | S100 calcium binding protein A10 | -0.0417228 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0415446 |
| THOC2 | THO complex 2 | -0.041181 |
| NRG1 | neuregulin 1 | -0.0410949 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0408552 |
| RPS13 | ribosomal protein S13 | -0.0405079 |
| APOE | apolipoprotein E | -0.0403042 |
| PRTG | protogenin | -0.0400154 |
| RPL34 | ribosomal protein L34 | -0.0399543 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0397423 |
| ANKRD12 | ankyrin repeat domain 12 | -0.039018 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.038748 |
| RPS24 | ribosomal protein S24 | -0.0387278 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0387256 |
| FTL | ferritin, light polypeptide | -0.0387143 |
| RPL30 | ribosomal protein L30 | -0.0383699 |
| CCN2 | cellular communication network factor 2 | -0.0381169 |
| RPS21 | ribosomal protein S21 | -0.0376667 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0373216 |
| PRELID2 | PRELI domain containing 2 | -0.0371474 |
| ACTG1 | actin gamma 1 | -0.0366777 |
| UBXN4 | UBX domain protein 4 | -0.0366644 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0359653 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0359094 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0357668 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.035607 |
| WASF2 | WAS protein family, member 2 | -0.0355775 |
| RPL36A | ribosomal protein L36a | -0.0350437 |
| LRRC4C | leucine rich repeat containing 4C | -0.0350142 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0345079 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0345022 |
| RSF1 | remodeling and spacing factor 1 | -0.0342705 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0339967 |
| SMIM44 | small integral membrane protein 44 | -0.0337222 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.033378 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0332663 |
| SERF2 | small EDRK-rich factor 2 | -0.0331203 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0327979 |
| RPL26 | ribosomal protein L26 | -0.0327277 |
| NKTR | natural killer cell triggering receptor | -0.0326864 |
| CUX1 | cut-like homeobox 1 | -0.0326339 |
| RPS27A | ribosomal protein S27a | -0.0325848 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0325519 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0323639 |
| RPL36 | ribosomal protein L36 | -0.0323583 |
| CCDC88A | coiled-coil domain containing 88A | -0.0322753 |
| RPL37A | ribosomal protein L37a | -0.0322665 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | -0.0321613 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0321415 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0319578 |
| MED12L | mediator complex subunit 12-like | -0.0318664 |
