Relugolix_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Relugolix perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Relugolix_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.115574
EGFR epidermal growth factor receptor 0.096411
TRIO trio Rho guanine nucleotide exchange factor 0.0832533
FAM13A family with sequence similarity 13, member A 0.0768491
ANXA5 annexin A5 0.0740409
CALD1 caldesmon 1 0.0733479
TGFBI transforming growth factor, beta-induced, 68kDa 0.0723397
MACF1 microtubule-actin crosslinking factor 1 0.0619693
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0584648
VEGFA vascular endothelial growth factor A 0.0580391
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0574401
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0566442
MYH9 myosin, heavy chain 9, non-muscle 0.0548845
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0531526
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0506413
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0496269
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0481796
ITGAV integrin, alpha V 0.0472536
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.046068
PRELID2 PRELI domain containing 2 0.0454249
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0438276
CALR calreticulin 0.0438232
FTH1 ferritin, heavy polypeptide 1 0.0432828
JMJD1C jumonji domain containing 1C 0.0423776
CCDC14 coiled-coil domain containing 14 0.0401177
WSB1 WD repeat and SOCS box containing 1 0.0393452
BPTF bromodomain PHD finger transcription factor 0.0392297
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0391333
B2M beta-2-microglobulin 0.0380622
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.038062
AFF4 AF4/FMR2 family, member 4 0.0376816
AKAP9 A kinase (PRKA) anchor protein 9 0.0372495
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.036945
VMP1 vacuole membrane protein 1 0.0368663
MYO10 myosin X 0.0362028
SAMD4A sterile alpha motif domain containing 4A 0.0361943
GOLGA4 golgin A4 0.0359809
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.03459
ZNF292 zinc finger protein 292 0.0339805
ZNF395 zinc finger protein 395 0.0339143
LIMS1 LIM and senescent cell antigen-like domains 1 0.0338934
FNDC3A fibronectin type III domain containing 3A 0.0334435
FMNL2 formin-like 2 0.0334394
RAI14 retinoic acid induced 14 0.032713
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0323206
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0322463
STC2 stanniocalcin 2 0.0319566
PGK1 phosphoglycerate kinase 1 0.0318285
ZBTB20 zinc finger and BTB domain containing 20 0.0314394
YTHDC1 YTH domain containing 1 0.0313872
ATP13A3 ATPase type 13A3 0.0313309
HDAC9 histone deacetylase 9 0.0311579
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0307902
KDM2A lysine (K)-specific demethylase 2A 0.0299589
ERBIN erbb2 interacting protein 0.0299083
TNIP1 TNFAIP3 interacting protein 1 0.0298394
RAD50 RAD50 homolog (S. cerevisiae) 0.0293541
RAB2A RAB2A, member RAS oncogene family 0.0291107
COL5A1 collagen, type V, alpha 1 0.0288242
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0286539
LOXL2 lysyl oxidase-like 2 0.0285367
HSPH1 heat shock 105kDa/110kDa protein 1 0.0285245
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0283807
ANKRD28 ankyrin repeat domain 28 0.0281949
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0279808
PDIA6 protein disulfide isomerase family A, member 6 0.0279178
HIP1 huntingtin interacting protein 1 0.0275109
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0274985
RPL37A ribosomal protein L37a 0.027397
CYLD cylindromatosis (turban tumor syndrome) 0.0273535
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0271324
RNF145 ring finger protein 145 0.0268097
GLG1 golgi glycoprotein 1 0.026693
TPM4 tropomyosin 4 0.0264341
BACE2 beta-site APP-cleaving enzyme 2 0.026215
FNDC3B fibronectin type III domain containing 3B 0.0261909
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0256132
ABLIM3 actin binding LIM protein family, member 3 0.025547
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0251412
UTRN utrophin 0.0250547
FRMD6 FERM domain containing 6 0.0249801
C5ORF15 chromosome 5 open reading frame 15 0.0249221
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0248885
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0247982
MEF2A myocyte enhancer factor 2A 0.0246199
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0245801
RBM25 RNA binding motif protein 25 0.0244366
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0244318
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0243835
IL6 interleukin 6 0.0242533
DSCAM Down syndrome cell adhesion molecule 0.0241687
FLOT1 flotillin 1 0.0241246
SMC5 structural maintenance of chromosomes 5 0.024121
AKAP12 A kinase (PRKA) anchor protein 12 0.0239931
ACTN4 actinin, alpha 4 0.0239855
BCAR3 breast cancer anti-estrogen resistance 3 0.023973
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0239641
CD59 CD59 molecule, complement regulatory protein 0.0239368
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0238566
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0238505

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.174097
TMSB10 thymosin beta 10 -0.109379
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.08344
PTMA prothymosin, alpha -0.0729097
COL6A1 collagen, type VI, alpha 1 -0.0723558
COL1A1 collagen, type I, alpha 1 -0.0683667
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0659117
SDC4 syndecan 4 -0.0623028
PSD3 pleckstrin and Sec7 domain containing 3 -0.0570628
LOC112694756 uncharaterized LOC112694756 -0.0520461
COL1A2 collagen, type I, alpha 2 -0.0512948
CCNI cyclin I -0.049086
HMGA2 high mobility group AT-hook 2 -0.047901
LOX lysyl oxidase -0.0476879
GNAS GNAS complex locus -0.0474208
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0431776
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0431172
SOD2 superoxide dismutase 2, mitochondrial -0.0419702
PDE4D phosphodiesterase 4D, cAMP-specific -0.0415446
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0414943
MT1X metallothionein 1X -0.0400093
RIGI RNA sensor RIG-I -0.0378717
FTL ferritin, light polypeptide -0.0378027
HLA-A major histocompatibility complex, class I, A -0.037027
ELL2 elongation factor, RNA polymerase II, 2 -0.0366275
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0354688
CD109 CD109 molecule -0.0350009
TNNC1 troponin C type 1 (slow) -0.0346431
H3-3B H3.3 histone B -0.034588
CANX calnexin -0.0316207
SEPTIN7 septin 7 -0.0315938
AHNAK AHNAK nucleoprotein -0.0309087
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.030758
S100A6 S100 calcium binding protein A6 -0.0301935
RRBP1 ribosome binding protein 1 -0.0301628
FUS FUS RNA binding protein -0.0300713
RPL34 ribosomal protein L34 -0.0291403
NALF1 NALCN channel auxiliary factor 1 -0.0288393
F3 coagulation factor III (thromboplastin, tissue factor) -0.0280533
BASP1 brain abundant, membrane attached signal protein 1 -0.0279268
IFRD1 interferon-related developmental regulator 1 -0.0277796
UBC ubiquitin C -0.0277091
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0276383
HMGB1 high mobility group box 1 -0.0271146
HLA-C major histocompatibility complex, class I, C -0.0270881
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0270812
CST3 cystatin C -0.0270512
ARF1 ADP-ribosylation factor 1 -0.0269835
TPX2 TPX2, microtubule-associated -0.0268661
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0267048
MT2A metallothionein 2A -0.0264913
EFNA5 ephrin-A5 -0.0264217
KDM5B lysine (K)-specific demethylase 5B -0.0259034
HM13 histocompatibility (minor) 13 -0.0258272
NIPBL Nipped-B homolog (Drosophila) -0.025783
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0255987
PKM pyruvate kinase, muscle -0.0251018
NUMB numb homolog (Drosophila) -0.0249727
EGR1 early growth response 1 -0.0246201
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0245129
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0238874
TAGLN2 transgelin 2 -0.0234153
RPN2 ribophorin II -0.0230118
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0228252
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0228066
RPL28 ribosomal protein L28 -0.0224153
DLG1 discs, large homolog 1 (Drosophila) -0.0222742
PTBP2 polypyrimidine tract binding protein 2 -0.022202
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0221827
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0221815
RPS14 ribosomal protein S14 -0.0220558
HMGB2 high mobility group box 2 -0.0219694
LMAN1 lectin, mannose-binding, 1 -0.0218151
SQSTM1 sequestosome 1 -0.0217992
SLC38A1 solute carrier family 38, member 1 -0.0217332
CBX3 chromobox homolog 3 -0.0215749
CENPF centromere protein F, 350/400kDa -0.021565
STC1 stanniocalcin 1 -0.0213621
PHF20 PHD finger protein 20 -0.0213561
GUK1 guanylate kinase 1 -0.0213107
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0210114
TXNIP thioredoxin interacting protein -0.0209808
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0209637
SEC31A SEC31 homolog A (S. cerevisiae) -0.0209568
TFPI2 tissue factor pathway inhibitor 2 -0.0209411
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0209052
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0208175
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0207928
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0207376
RPLP1 ribosomal protein, large, P1 -0.0206317
TMEM167A transmembrane protein 167A -0.0205799
TUBB tubulin, beta class I -0.0203795
KIF20B kinesin family member 20B -0.0203693
RND3 Rho family GTPase 3 -0.0203158
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.020175
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0201013
ZNFX1 zinc finger, NFX1-type containing 1 -0.0200663
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0199015
DIAPH3 diaphanous-related formin 3 -0.0198666
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.019828