Renal cell carcinoma Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description A carcinoma arising from the renal parenchyma. The incidence of renal cell carcinoma has increased by 35% from 1973 to 1991. There is a strong correlation between cigarette smoking and the development of renal cell carcinoma. The clinical presentation includes : hematuria, flank pain and a palpable lumbar mass. A high percentage of renal cell carcinomas are diagnosed when an ultrasound is performed for other purposes. Diagnostic procedures include: ultra sound, intravenous pyelography and computed tomography (CT). Radical nephrectomy is the standard intervention procedure. Renal cell carcinoma is generally considered to be resistant to radiation treatment and chemotherapy.|A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma. (Experimental Factor Ontology, EFO_0000681)
External Link https://www.kegg.jp/entry/hsa05211
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Genes

66 proteins participating in the Renal cell carcinoma pathway from the KEGG Pathways 2026 dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BAD BCL2-associated agonist of cell death
BRAF B-Raf proto-oncogene, serine/threonine kinase
BUB1B-PAK6 BUB1B-PAK6 readthrough
CDC42 cell division cycle 42
CDPF1 cysteine-rich, DPF motif domain containing 1
CLSTN1 calsyntenin 1
CREBBP CREB binding protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CUL2 cullin 2
EGLN1 egl-9 family hypoxia-inducible factor 1
EGLN2 egl-9 family hypoxia-inducible factor 2
EGLN3 egl-9 family hypoxia-inducible factor 3
ELOB elongin B
ELOC elongin C
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FLCN folliculin
GRB2 growth factor receptor-bound protein 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HRAS Harvey rat sarcoma viral oncogene homolog
JUN jun proto-oncogene
LDLR low density lipoprotein receptor
LNCEGFL7OS lncRNA EGFL7 opposite strand
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MIA3 melanoma inhibitory activity family, member 3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDGFB platelet-derived growth factor beta polypeptide
PIGU phosphatidylinositol glycan anchor biosynthesis, class U
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKN1 protein kinase N1
PKN2 protein kinase N2
PRCC papillary renal cell carcinoma (translocation-associated)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE3 ribonuclease, RNase A family, 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLTM SAFB-like, transcription modulator
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
TFE3 transcription factor binding to IGHM enhancer 3
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase