Renin secretion Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. Renin is synthesized, stored in, and released into circulation by the juxtaglomerular (JG) cells of the kidney. Secretion of renin from JG cells at the organ level is controlled by the four main mechanisms: the sympathetic nervous system, the local JG apparatus baroreflex, the macula densa mechanism, and several hormones acting locally within the JG apparatus. Renin secretion at the level of renal JG cells appears to be controlled mainly by classic second messengers, namely cAMP, cGMP, and free cytosolic calcium concentration. While cAMP generally stimulates renin release and the intracellular calcium concentration suppresses the exocytosis of renin, the effects of cGMP in the regulation of the renin system are more complex as it both may stimulate or inhibit renin release. (Kyoto Encyclopedia of Genes and Genomes, hsa04924)
External Link https://www.kegg.jp/entry/hsa04924
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Genes

69 proteins participating in the Renin secretion pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADORA1 adenosine A1 receptor
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGTR1 angiotensin II receptor, type 1
AGXT alanine-glyoxylate aminotransferase
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CALML3 calmodulin-like 3
CALML4 calmodulin-like 4
CALML5 calmodulin-like 5
CALML6 calmodulin-like 6
CLCA1 chloride channel accessory 1
CLCA2 chloride channel accessory 2
CLCA4 chloride channel accessory 4
CREB1 cAMP responsive element binding protein 1
CTSB cathepsin B
EDN1 endothelin 1
EDN2 endothelin 2
EDN3 endothelin 3
EDNRA endothelin receptor type A
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNAS GNAS complex locus
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD11 potassium channel tetramerization domain containing 11
MINDY4 MINDY lysine 48 deubiquitinase 4
NPPA natriuretic peptide A
NPR1 natriuretic peptide receptor 1
ORAI1 ORAI calcium release-activated calcium modulator 1
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDE1B phosphodiesterase 1B, calmodulin-dependent
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE3B phosphodiesterase 3B, cGMP-inhibited
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB2 phospholipase C, beta 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCB4 phospholipase C, beta 4
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PPP3R2 protein phosphatase 3, regulatory subunit B, beta
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCA protein kinase C, alpha
PRKG2 protein kinase, cGMP-dependent, type II
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)