Restless Legs Syndrome Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A central nervous system disease characterized by throbbing, pulling creeping or other unpleasant sensations in the legs and the irresistible urge to move them. (Human Disease Ontology, DOID_0050425)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D012148
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Genes

33 genes/proteins associated with the disease Restless Legs Syndrome from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
BTBD9 BTB (POZ) domain containing 9 2.88009
POMC proopiomelanocortin 2.88009
PTPRD protein tyrosine phosphatase, receptor type, D 2.88009
RLS3 Restless legs syndrome 3 2.88009
RLS2 Restless legs syndrome 2 2.88009
RLS1 Restless legs syndrome, susceptibility to 2.88009
RLS7 Restless legs syndrome 7 2.88009
RLS6 Restless legs syndrome, susceptibility to, 6 2.88009
RLS5 Restless legs syndrome, susceptibility to, 5 2.88009
MEIS1 Meis homeobox 1 2.88009
RLS4 Restless legs syndrome 4 2.88009
TF transferrin 2.88009
DRD2 dopamine receptor D2 1.83378
PRL prolactin 1.75142
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.64797
DRD3 dopamine receptor D3 1.555
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 1.51355
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.35127
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.31626
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.29875
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.29041
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.27162
CAT catalase 1.22758
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.22501
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.22501
DRD1 dopamine receptor D1 1.19445
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.19113
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.1753
BDNF brain-derived neurotrophic factor 1.16467
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.10317
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.09471
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.06734
MAPK3 mitogen-activated protein kinase 3 1.01587