Restless Legs Syndrome Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A central nervous system disease characterized by throbbing, pulling creeping or other unpleasant sensations in the legs and the irresistible urge to move them. (Human Disease Ontology, DOID_0050425)
External Link https://www.disgenet.org/browser/0/1/0/C0035258
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Genes

110 genes associated with the disease Restless Legs Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AFP alpha-fetoprotein
APLN apelin
ATL1 atlastin GTPase 1
ATRN attractin
ATXN1 ataxin 1
ATXN2 ataxin 2
ATXN3 ataxin 3
ATXN7 ataxin 7
AVP arginine vasopressin
BTBD9 BTB (POZ) domain containing 9
C3 complement component 3
C9ORF72 chromosome 9 open reading frame 72
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CCDC148 coiled-coil domain containing 148
CHKB choline kinase beta
CHM choroideremia (Rab escort protein 1)
CHMP2B charged multivesicular body protein 2B
CNTN3 contactin 3 (plasmacytoma associated)
CPT1B carnitine palmitoyltransferase 1B (muscle)
CRP C-reactive protein, pentraxin-related
DBP D site of albumin promoter (albumin D-box) binding protein
DMRT1 doublesex and mab-3 related transcription factor 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FAT2 FAT atypical cadherin 2
FGF23 fibroblast growth factor 23
FMR1 fragile X mental retardation 1
FTL ferritin, light polypeptide
FXN frataxin
FXYD1 FXYD domain containing ion transport regulator 1
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene)
GCH1 GTP cyclohydrolase 1
GEMIN2 gem (nuclear organelle) associated protein 2
GLO1 glyoxalase I
HAMP hepcidin antimicrobial peptide
HFE hemochromatosis
HMOX1 heme oxygenase 1
HMOX2 heme oxygenase 2
HNMT histamine N-methyltransferase
HTRA2 HtrA serine peptidase 2
IL17A interleukin 17A
IL1B interleukin 1, beta
KCTD18 potassium channel tetramerization domain containing 18
KNG1 kininogen 1
L1CAM L1 cell adhesion molecule
LITAF lipopolysaccharide-induced TNF factor
LRP2 low density lipoprotein receptor-related protein 2
LRRK2 leucine-rich repeat kinase 2
LY6E lymphocyte antigen 6 complex, locus E
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAP2K5 mitogen-activated protein kinase kinase 5
MCF2L MCF.2 cell line derived transforming sequence-like
MEIS1 Meis homeobox 1
MFN2 mitofusin 2
MIXL1 Mix paired-like homeobox
MOCOS molybdenum cofactor sulfurase
MPZ myelin protein zero
MYT1 myelin transcription factor 1
NANS N-acetylneuraminic acid synthase
NKX2-1 NK2 homeobox 1
NOS1 nitric oxide synthase 1 (neuronal)
NPAS2 neuronal PAS domain protein 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTS neurotensin
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PCDHA3 protocadherin alpha 3
PINK1 PTEN induced putative kinase 1
PODXL podocalyxin-like
POMC proopiomelanocortin
PTPRD protein tyrosine phosphatase, receptor type, D
PYCARD PYD and CARD domain containing
REEP1 receptor accessory protein 1
REN renin
RNMT RNA (guanine-7-) methyltransferase
SCAF11 SR-related CTD-associated factor 11
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SKOR1 SKI family transcriptional corepressor 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMCP sperm mitochondria-associated cysteine-rich protein
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPATS2L spermatogenesis associated, serine-rich 2-like
TBP TATA box binding protein
TF transferrin
TFRC transferrin receptor
TH tyrosine hydroxylase
TMPRSS6 transmembrane protease, serine 6
TNF tumor necrosis factor
TOX3 TOX high mobility group box family member 3
TRA T cell receptor alpha locus
TRAPPC6B trafficking protein particle complex 6B
TSPAN31 tetraspanin 31
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UTRN utrophin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
ZC4H2 zinc finger, C4H2 domain containing
ZEB2 zinc finger E-box binding homeobox 2