Resveratrol_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Resveratrol perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Resveratrol_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0921045
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0849217
NALF1 NALCN channel auxiliary factor 1 0.0791628
EZR ezrin 0.0771999
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0697974
NPSR1 neuropeptide S receptor 1 0.0637569
VEGFA vascular endothelial growth factor A 0.0611305
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0530942
FLNB filamin B, beta 0.052032
FAT1 FAT atypical cadherin 1 0.0505481
EMP1 epithelial membrane protein 1 0.0498296
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0477111
TXNIP thioredoxin interacting protein 0.0449838
MAML3 mastermind-like 3 (Drosophila) 0.0448906
CALB1 calbindin 1, 28kDa 0.0439166
PCBP2 poly(rC) binding protein 2 0.0429685
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0424896
ANXA1 annexin A1 0.0419378
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0413592
PTPRK protein tyrosine phosphatase, receptor type, K 0.0410987
ITGA6 integrin, alpha 6 0.0392159
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0390846
CCNY cyclin Y 0.0388909
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0382745
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0381582
PSD3 pleckstrin and Sec7 domain containing 3 0.0379613
PTEN phosphatase and tensin homolog 0.037252
NDRG1 N-myc downstream regulated 1 0.0370545
GREB1L growth regulation by estrogen in breast cancer-like 0.0342513
KRT8 keratin 8, type II 0.0341636
RNF217 ring finger protein 217 0.0320565
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.031997
PDE4D phosphodiesterase 4D, cAMP-specific 0.0310965
GLS2 glutaminase 2 (liver, mitochondrial) 0.0309116
ABHD2 abhydrolase domain containing 2 0.0294423
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0283606
UGCG UDP-glucose ceramide glucosyltransferase 0.0277445
MRPS6 mitochondrial ribosomal protein S6 0.0269962
MUC17 mucin 17, cell surface associated 0.0269419
DSPP dentin sialophosphoprotein 0.0264906
SLC35F3 solute carrier family 35, member F3 0.0250228
NCOR2 nuclear receptor corepressor 2 0.0249926
MBNL1 muscleblind-like splicing regulator 1 0.0246259
CCSER1 coiled-coil serine-rich protein 1 0.0242643
AKAP13 A kinase (PRKA) anchor protein 13 0.0241397
ZBTB20 zinc finger and BTB domain containing 20 0.0236915
PTK2 protein tyrosine kinase 2 0.02328
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0232303
PPARG peroxisome proliferator-activated receptor gamma 0.0232036
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.023137
ALCAM activated leukocyte cell adhesion molecule 0.0229694
DIAPH2 diaphanous-related formin 2 0.0220714
BIRC6 baculoviral IAP repeat containing 6 0.0217339
ANXA11 annexin A11 0.0215755
TES testin LIM domain protein 0.0214416
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0214381
TPM3 tropomyosin 3 0.0213916
MAML2 mastermind-like 2 (Drosophila) 0.021189
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0210356
ZFP36L2 ZFP36 ring finger protein-like 2 0.021011
RPL3 ribosomal protein L3 0.0206947
ADD3 adducin 3 (gamma) 0.0202456
AFF1 AF4/FMR2 family, member 1 0.0201888
PARD3B par-3 family cell polarity regulator beta 0.020162
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0200976
B2M beta-2-microglobulin 0.0199792
ADAM9 ADAM metallopeptidase domain 9 0.0199056
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0196423
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0195902
EGFR epidermal growth factor receptor 0.0195647
GCC2 GRIP and coiled-coil domain containing 2 0.0195012
PLCB4 phospholipase C, beta 4 0.0194749
KMT2C lysine (K)-specific methyltransferase 2C 0.0193918
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0193331
ERRFI1 ERBB receptor feedback inhibitor 1 0.0192787
EIF4A2 eukaryotic translation initiation factor 4A2 0.0192532
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0192477
RABGAP1L RAB GTPase activating protein 1-like 0.0191194
EEF1G eukaryotic translation elongation factor 1 gamma 0.0189125
TMSB4X thymosin beta 4, X-linked 0.0184178
EPHA2 EPH receptor A2 0.0182276
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0181079
MUC13 mucin 13, cell surface associated 0.0179108
FAM120A family with sequence similarity 120A 0.0176792
HDGF hepatoma-derived growth factor 0.0175865
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0175669
PTPRB protein tyrosine phosphatase, receptor type, B 0.0173927
JUP junction plakoglobin 0.0172477
PATJ PATJ crumbs cell polarity complex component 0.0170684
TRIO trio Rho guanine nucleotide exchange factor 0.0168303
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0167369
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0167223
CLOCK clock circadian regulator 0.0166973
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0166384
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0165123
PACS1 phosphofurin acidic cluster sorting protein 1 0.0162364
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.0161982
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0161494
ANXA2 annexin A2 0.0161255
LIMS1 LIM and senescent cell antigen-like domains 1 0.0160526

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.220279
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.198499
PTMA prothymosin, alpha -0.183699
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.102973
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0835481
TPT1 tumor protein, translationally-controlled 1 -0.0714835
TMSB10 thymosin beta 10 -0.0684525
RNF43 ring finger protein 43 -0.0621036
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0607335
RPS6 ribosomal protein S6 -0.0578384
H1-0 H1.0 linker histone -0.0562537
ONECUT3 one cut homeobox 3 -0.0556435
RBM39 RNA binding motif protein 39 -0.0511874
ACTG1 actin gamma 1 -0.0510852
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0497372
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.048583
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0426617
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0404865
RPLP1 ribosomal protein, large, P1 -0.0396407
KDM3A lysine (K)-specific demethylase 3A -0.0393769
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0388052
CD44 CD44 molecule (Indian blood group) -0.0377582
RPLP2 ribosomal protein, large, P2 -0.0372659
FTL ferritin, light polypeptide -0.0355878
PNISR PNN-interacting serine/arginine-rich protein -0.0354423
RPL9 ribosomal protein L9 -0.034779
RRBP1 ribosome binding protein 1 -0.034719
GMDS GDP-mannose 4,6-dehydratase -0.0346859
CLTC clathrin, heavy chain (Hc) -0.034409
GOLGA4 golgin A4 -0.0341157
RPL34 ribosomal protein L34 -0.0340406
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0330869
RAB10 RAB10, member RAS oncogene family -0.0330794
IER3 immediate early response 3 -0.0319913
HMGB1 high mobility group box 1 -0.0318605
ARF1 ADP-ribosylation factor 1 -0.0314678
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0311572
EIF1 eukaryotic translation initiation factor 1 -0.0311316
FTH1 ferritin, heavy polypeptide 1 -0.0307827
GARS1 glycyl-tRNA synthetase 1 -0.0304444
RAD21 RAD21 homolog (S. pombe) -0.0302289
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0296039
RPS24 ribosomal protein S24 -0.0295696
RAB1A RAB1A, member RAS oncogene family -0.0292242
ANKRD11 ankyrin repeat domain 11 -0.0290829
OGA O-GlcNAcase -0.028709
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0286379
KLF5 Kruppel-like factor 5 (intestinal) -0.027971
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0273989
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0273603
SENP5 SUMO1/sentrin specific peptidase 5 -0.02632
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0262771
RPS21 ribosomal protein S21 -0.0262276
CANX calnexin -0.0254858
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.0252262
ETNK1 ethanolamine kinase 1 -0.0247423
RPL5 ribosomal protein L5 -0.0245625
ATP5F1B ATP synthase F1 subunit beta -0.0244641
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0243766
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0242165
RPS19 ribosomal protein S19 -0.0240595
HMGB2 high mobility group box 2 -0.0239468
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0239367
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0236601
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0235778
RPL32 ribosomal protein L32 -0.0232186
RPL23 ribosomal protein L23 -0.0231394
MYL12B myosin, light chain 12B, regulatory -0.023021
HDLBP high density lipoprotein binding protein -0.0229737
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0229707
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.02295
TNS4 tensin 4 -0.0227262
RPL11 ribosomal protein L11 -0.0227153
IARS1 isoleucyl-tRNA synthetase 1 -0.0226516
RPL35A ribosomal protein L35a -0.0222979
RPS2 ribosomal protein S2 -0.022276
ABLIM1 actin binding LIM protein 1 -0.0218744
NAP1L1 nucleosome assembly protein 1-like 1 -0.0217675
RPL38 ribosomal protein L38 -0.0214022
JAK1 Janus kinase 1 -0.0211914
RBM25 RNA binding motif protein 25 -0.0211886
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0211672
CCND1 cyclin D1 -0.0211365
RPS8 ribosomal protein S8 -0.0210065
WDR45B WD repeat domain 45B -0.0209334
RPL8 ribosomal protein L8 -0.0209043
UBE2H ubiquitin-conjugating enzyme E2H -0.0208566
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0208094
CENPF centromere protein F, 350/400kDa -0.0205761
TOP1 topoisomerase (DNA) I -0.0205506
TUBB4B tubulin, beta 4B class IVb -0.0205461
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0204674
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0204182
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0203889
RPLP0 ribosomal protein, large, P0 -0.0203794
PRRC2C proline-rich coiled-coil 2C -0.0203397
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0202796
CTBP2 C-terminal binding protein 2 -0.0201721
KIF5B kinesin family member 5B -0.0201526
RESF1 retroelement silencing factor 1 -0.0201414