Resveratrol_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Resveratrol perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Resveratrol_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CAPRIN2 caprin family member 2 0.108211
DST dystonin 0.0934088
FMNL2 formin-like 2 0.0817653
ZDHHC14 zinc finger, DHHC-type containing 14 0.0765615
MT1X metallothionein 1X 0.0753856
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0722207
RPS12 ribosomal protein S12 0.0702885
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0673583
PSD3 pleckstrin and Sec7 domain containing 3 0.0667645
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0648877
TSC22D1 TSC22 domain family, member 1 0.0643025
FTL ferritin, light polypeptide 0.0574066
RPL12 ribosomal protein L12 0.0555386
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0511783
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0509501
ZFP36L1 ZFP36 ring finger protein-like 1 0.0503606
RPS6 ribosomal protein S6 0.0501193
TXNIP thioredoxin interacting protein 0.0489804
KMT2E lysine (K)-specific methyltransferase 2E 0.0464594
POTEF POTE ankyrin domain family, member F 0.0462206
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0449011
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0441031
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.043535
RUNX1 runt-related transcription factor 1 0.0432711
RPL35A ribosomal protein L35a 0.043176
BCAR3 breast cancer anti-estrogen resistance 3 0.0423963
RAB27B RAB27B, member RAS oncogene family 0.040749
OSBPL8 oxysterol binding protein-like 8 0.0395244
DNER delta/notch-like EGF repeat containing 0.038139
VMP1 vacuole membrane protein 1 0.037441
SDK1 sidekick cell adhesion molecule 1 0.0373715
ANGPTL4 angiopoietin-like 4 0.0370378
SRPK2 SRSF protein kinase 2 0.0368161
PCBP2 poly(rC) binding protein 2 0.0366331
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.036243
WSB1 WD repeat and SOCS box containing 1 0.0361736
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.035812
EIF4A2 eukaryotic translation initiation factor 4A2 0.0345586
CADM2 cell adhesion molecule 2 0.0344557
PCDH1 protocadherin 1 0.0340833
RPL36 ribosomal protein L36 0.0336868
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0322402
TPT1 tumor protein, translationally-controlled 1 0.0315913
CCNL1 cyclin L1 0.0315105
RPL27 ribosomal protein L27 0.029194
RBM39 RNA binding motif protein 39 0.0291276
DDIT4 DNA-damage-inducible transcript 4 0.0290837
EEF1G eukaryotic translation elongation factor 1 gamma 0.028957
RPS19 ribosomal protein S19 0.0283612
HMGA1 high mobility group AT-hook 1 0.0280751
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0280502
RPS17 ribosomal protein S17 0.0278101
RPS3 ribosomal protein S3 0.0277287
MARK3 MAP/microtubule affinity-regulating kinase 3 0.027385
RAB7A RAB7A, member RAS oncogene family 0.0273558
VEGFA vascular endothelial growth factor A 0.0265291
RPL23 ribosomal protein L23 0.0263113
RPS27 ribosomal protein S27 0.0261649
RPS23 ribosomal protein S23 0.0256692
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.025529
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0254996
MT2A metallothionein 2A 0.0250204
CCNY cyclin Y 0.0249415
FOSL1 FOS-like antigen 1 0.0248417
PRKCE protein kinase C, epsilon 0.0245836
ZNF292 zinc finger protein 292 0.0245636
AMBRA1 autophagy/beclin-1 regulator 1 0.0243357
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0242836
PIAS2 protein inhibitor of activated STAT, 2 0.0241988
SLK STE20-like kinase 0.0240049
FNBP1L formin binding protein 1-like 0.0239761
SETD5 SET domain containing 5 0.0238783
WDR27 WD repeat domain 27 0.0237316
NPEPPS aminopeptidase puromycin sensitive 0.0237141
KLF6 Kruppel-like factor 6 0.0235712
RNF145 ring finger protein 145 0.0234743
RPL31 ribosomal protein L31 0.0233669
DNAH14 dynein, axonemal, heavy chain 14 0.0230036
RPL3 ribosomal protein L3 0.0230005
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.02295
GARS1 glycyl-tRNA synthetase 1 0.0227208
MATR3 matrin 3 0.0221683
RPL26 ribosomal protein L26 0.0218471
TGM2 transglutaminase 2 0.0215927
QKI QKI, KH domain containing, RNA binding 0.0215385
RPLP1 ribosomal protein, large, P1 0.0210741
HLA-A major histocompatibility complex, class I, A 0.0207293
RPS8 ribosomal protein S8 0.0205787
ERRFI1 ERBB receptor feedback inhibitor 1 0.0202772
EREG epiregulin 0.0201127
ZNF326 zinc finger protein 326 0.0199167
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0197942
RIOK3 RIO kinase 3 0.0196794
AGTPBP1 ATP/GTP binding protein 1 0.0194747
BRD2 bromodomain containing 2 0.019434
CSMD3 CUB and Sushi multiple domains 3 0.0192994
ADAM17 ADAM metallopeptidase domain 17 0.0192843
PACS1 phosphofurin acidic cluster sorting protein 1 0.0190678
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0189671
SRSF11 serine/arginine-rich splicing factor 11 0.0188852

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.189665
TXNRD1 thioredoxin reductase 1 -0.145101
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.124961
TM4SF1 transmembrane 4 L six family member 1 -0.111503
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.101845
LOC112694756 uncharaterized LOC112694756 -0.0881868
WARS1 tryptophanyl-tRNA synthetase 1 -0.0878173
SRGN serglycin -0.0864865
ACTG1 actin gamma 1 -0.0806943
EHBP1 EH domain binding protein 1 -0.0788351
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0643176
PGK1 phosphoglycerate kinase 1 -0.0596598
VIM vimentin -0.0591356
HDLBP high density lipoprotein binding protein -0.0587252
PTMA prothymosin, alpha -0.057513
DLG1 discs, large homolog 1 (Drosophila) -0.0568857
CD44 CD44 molecule (Indian blood group) -0.0566331
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0555353
MKI67 marker of proliferation Ki-67 -0.0552805
CENPF centromere protein F, 350/400kDa -0.0527825
CANX calnexin -0.0527221
RIGI RNA sensor RIG-I -0.0524878
ENO1 enolase 1, (alpha) -0.0522555
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.05095
RAI1 retinoic acid induced 1 -0.050029
SLC38A2 solute carrier family 38, member 2 -0.0496654
AHNAK AHNAK nucleoprotein -0.0476163
TAS2R14 taste receptor, type 2, member 14 -0.046325
KPNB1 karyopherin (importin) beta 1 -0.0443081
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0441086
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0439362
GCLM glutamate-cysteine ligase, modifier subunit -0.0438623
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0433575
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0430654
ZNF217 zinc finger protein 217 -0.0426832
CSNK1A1 casein kinase 1, alpha 1 -0.042322
ZMYND8 zinc finger, MYND-type containing 8 -0.0421881
LDHA lactate dehydrogenase A -0.0406897
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0401669
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0397057
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0386757
TMSB10 thymosin beta 10 -0.0378308
BPTF bromodomain PHD finger transcription factor -0.0377124
SMC4 structural maintenance of chromosomes 4 -0.0373713
HLA-B major histocompatibility complex, class I, B -0.0364987
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0362839
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0362257
IFIH1 interferon induced with helicase C domain 1 -0.0356512
OSMR oncostatin M receptor -0.0356126
CAVIN1 caveolae associated protein 1 -0.0355711
ANLN anillin, actin binding protein -0.0350324
RRBP1 ribosome binding protein 1 -0.034447
SETX senataxin -0.0341591
LOXL2 lysyl oxidase-like 2 -0.0338822
TUBB tubulin, beta class I -0.033611
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0333852
ANKRD11 ankyrin repeat domain 11 -0.0326165
USP34 ubiquitin specific peptidase 34 -0.0323337
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0319778
YEATS2 YEATS domain containing 2 -0.0317862
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0316447
DIAPH3 diaphanous-related formin 3 -0.031382
CAPN2 calpain 2, (m/II) large subunit -0.0312412
SRRM2 serine/arginine repetitive matrix 2 -0.0311712
ARHGAP29 Rho GTPase activating protein 29 -0.0309378
LMAN1 lectin, mannose-binding, 1 -0.0307791
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0304984
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0299586
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0299053
ETNK1 ethanolamine kinase 1 -0.0298718
GOLGB1 golgin B1 -0.0297925
CEP170 centrosomal protein 170kDa -0.0297145
VCL vinculin -0.0294324
ANXA1 annexin A1 -0.0293351
FBXO11 F-box protein 11 -0.0291975
MYO10 myosin X -0.0290952
HJURP Holliday junction recognition protein -0.0290808
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0289032
AFF4 AF4/FMR2 family, member 4 -0.028778
IFI6 interferon, alpha-inducible protein 6 -0.0284532
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0284461
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0282851
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0280065
SCGB1D1 secretoglobin, family 1D, member 1 -0.0279473
ZBTB38 zinc finger and BTB domain containing 38 -0.027888
ANXA2 annexin A2 -0.0278749
ANTXR2 anthrax toxin receptor 2 -0.0274686
NSD2 nuclear receptor binding SET domain protein 2 -0.0274323
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.027413
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0273966
RTN4 reticulon 4 -0.0273596
CALU calumenin -0.0272688
TMSB4X thymosin beta 4, X-linked -0.0272501
BRCA2 breast cancer 2, early onset -0.0266392
ACTN4 actinin, alpha 4 -0.0265599
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0265213
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0260026
MACF1 microtubule-actin crosslinking factor 1 -0.0259124
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0259024
EZR ezrin -0.0257547