Resveratrol_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Resveratrol perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Resveratrol_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.322521
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.152638
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0921625
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0739401
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0553149
THSD4 thrombospondin, type I, domain containing 4 0.0527629
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0496892
FTH1 ferritin, heavy polypeptide 1 0.0426956
S100A10 S100 calcium binding protein A10 0.0426293
CEMIP cell migration inducing protein, hyaluronan binding 0.0420126
SMAD3 SMAD family member 3 0.039464
IGFBP3 insulin-like growth factor binding protein 3 0.0380656
EFNA5 ephrin-A5 0.0376446
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.037149
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0369151
CAV2 caveolin 2 0.0364552
CAV1 caveolin 1, caveolae protein, 22kDa 0.0360866
RNF213 ring finger protein 213 0.0355819
SAMD4A sterile alpha motif domain containing 4A 0.0330674
BACE2 beta-site APP-cleaving enzyme 2 0.0317828
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0303044
CCSER1 coiled-coil serine-rich protein 1 0.0283462
LOC112694756 uncharaterized LOC112694756 0.0270061
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0252693
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0250625
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.024154
EPAS1 endothelial PAS domain protein 1 0.0239991
MX1 MX dynamin-like GTPase 1 0.0236984
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0236218
FNDC3B fibronectin type III domain containing 3B 0.0228367
VEGFC vascular endothelial growth factor C 0.0226943
SOD2 superoxide dismutase 2, mitochondrial 0.0216597
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0208915
AKAP12 A kinase (PRKA) anchor protein 12 0.020883
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0207016
IGFBP5 insulin-like growth factor binding protein 5 0.0203698
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0200165
LDHA lactate dehydrogenase A 0.0199929
ZMYND8 zinc finger, MYND-type containing 8 0.0198331
ACTG1 actin gamma 1 0.019125
PYGL phosphorylase, glycogen, liver 0.0188762
MBNL2 muscleblind-like splicing regulator 2 0.0188619
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.01869
ENO1 enolase 1, (alpha) 0.0185828
RAD51B RAD51 paralog B 0.0184376
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0181467
TRAPPC9 trafficking protein particle complex 9 0.0180032
TMEM45B transmembrane protein 45B 0.0179013
FOXP1 forkhead box P1 0.0174393
PACS1 phosphofurin acidic cluster sorting protein 1 0.0172219
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0168919
PTPRM protein tyrosine phosphatase, receptor type, M 0.0167038
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0165672
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0159652
BABAM2 BRISC and BRCA1 A complex member 2 0.0159444
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0159116
EGR1 early growth response 1 0.01583
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0157253
TRIO trio Rho guanine nucleotide exchange factor 0.0156819
BIRC3 baculoviral IAP repeat containing 3 0.0155392
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0153632
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0151894
GPC5 glypican 5 0.0151157
CCND1 cyclin D1 0.0148845
TPM4 tropomyosin 4 0.0146621
AHNAK AHNAK nucleoprotein 0.0146437
CUX1 cut-like homeobox 1 0.0144484
PARP9 poly (ADP-ribose) polymerase family, member 9 0.0144393
LGALS12 lectin, galactoside-binding, soluble, 12 0.0143953
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0143406
CABLES1 Cdk5 and Abl enzyme substrate 1 0.0139586
DOCK1 dedicator of cytokinesis 1 0.0136036
DISC1 disrupted in schizophrenia 1 0.013602
IGF1R insulin-like growth factor 1 receptor 0.0135301
PKM pyruvate kinase, muscle 0.0135283
EPS8 epidermal growth factor receptor pathway substrate 8 0.0133106
SP100 SP100 nuclear antigen 0.0132987
CCDC91 coiled-coil domain containing 91 0.0132867
KRT18 keratin 18, type I 0.0131639
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0129945
ANAPC16 anaphase promoting complex subunit 16 0.0129715
PSEN1 presenilin 1 0.0127973
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0126442
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0125831
LPP LIM domain containing preferred translocation partner in lipoma 0.0125644
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0125601
USO1 USO1 vesicle transport factor 0.0125224
AFF1 AF4/FMR2 family, member 1 0.0124214
MAML2 mastermind-like 2 (Drosophila) 0.0123911
PMP22 peripheral myelin protein 22 0.0123503
TXNIP thioredoxin interacting protein 0.0123234
PCBP2 poly(rC) binding protein 2 0.0122645
ICA1 islet cell autoantigen 1, 69kDa 0.0122021
IFI44L interferon-induced protein 44-like 0.0121649
NIBAN2 niban apoptosis regulator 2 0.0120668
CRYBG3 beta-gamma crystallin domain containing 3 0.0119838
INTS6 integrator complex subunit 6 0.0119761
ZSWIM6 zinc finger, SWIM-type containing 6 0.0119403
SHB Src homology 2 domain containing adaptor protein B 0.0119071
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.0118906

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.173278
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.111852
LAMC2 laminin, gamma 2 -0.0906578
TOP1 topoisomerase (DNA) I -0.0846014
NDRG1 N-myc downstream regulated 1 -0.0721533
PRRC2C proline-rich coiled-coil 2C -0.0705544
LAMA4 laminin, alpha 4 -0.0704752
NAMPT nicotinamide phosphoribosyltransferase -0.0697316
SPAG9 sperm associated antigen 9 -0.0672955
TMSB10 thymosin beta 10 -0.0596153
FTL ferritin, light polypeptide -0.0585269
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0584197
RBM39 RNA binding motif protein 39 -0.0534911
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.050073
MT2A metallothionein 2A -0.0492524
ELL2 elongation factor, RNA polymerase II, 2 -0.0491449
TES testin LIM domain protein -0.0474947
LRP1B low density lipoprotein receptor-related protein 1B -0.0472265
H1-0 H1.0 linker histone -0.0470543
CAMTA1 calmodulin binding transcription activator 1 -0.0453083
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0450482
MKI67 marker of proliferation Ki-67 -0.0433587
TPT1 tumor protein, translationally-controlled 1 -0.0425253
ZFC3H1 zinc finger, C3H1-type containing -0.042032
RPS3 ribosomal protein S3 -0.040575
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0405469
OSMR oncostatin M receptor -0.038914
SEC61G Sec61 gamma subunit -0.0387684
RTN4 reticulon 4 -0.0387225
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0385065
GSK3B glycogen synthase kinase 3 beta -0.0377442
TMEM165 transmembrane protein 165 -0.0377171
ZC3H11A zinc finger CCCH-type containing 11A -0.0374509
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0373765
PTMA prothymosin, alpha -0.0370231
BRWD3 bromodomain and WD repeat domain containing 3 -0.036409
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0363102
PUM2 pumilio RNA-binding family member 2 -0.0350702
NABP1 nucleic acid binding protein 1 -0.0348308
JMJD1C jumonji domain containing 1C -0.0347253
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0342199
PGK1 phosphoglycerate kinase 1 -0.0334686
LAMB3 laminin, beta 3 -0.0333096
GRAMD1B GRAM domain containing 1B -0.0328468
RUNX1 runt-related transcription factor 1 -0.0326446
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0323184
ANKRD11 ankyrin repeat domain 11 -0.0320997
LMO7 LIM domain 7 -0.031908
BRWD1 bromodomain and WD repeat domain containing 1 -0.0313958
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0309653
ARGLU1 arginine and glutamate rich 1 -0.0301488
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0300869
SON SON DNA binding protein -0.0295827
USP34 ubiquitin specific peptidase 34 -0.0295816
WDR45B WD repeat domain 45B -0.0292402
TSC22D2 TSC22 domain family, member 2 -0.0291039
ZFAND6 zinc finger, AN1-type domain 6 -0.029065
BLZF1 basic leucine zipper nuclear factor 1 -0.0289614
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -0.0285237
CCNL1 cyclin L1 -0.0284127
USP53 ubiquitin specific peptidase 53 -0.0283657
SLC38A1 solute carrier family 38, member 1 -0.0281853
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0280009
ARHGAP32 Rho GTPase activating protein 32 -0.0278682
KMT2E lysine (K)-specific methyltransferase 2E -0.0277112
SYAP1 synapse associated protein 1 -0.0275393
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0271766
ANKRD17 ankyrin repeat domain 17 -0.027066
OGA O-GlcNAcase -0.0270233
UVRAG UV radiation resistance associated -0.0269987
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0268906
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0268229
RAP1B RAP1B, member of RAS oncogene family -0.0267294
NPTN neuroplastin -0.026557
RAB1A RAB1A, member RAS oncogene family -0.0265094
CSNK1A1 casein kinase 1, alpha 1 -0.0264815
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0264397
SETD5 SET domain containing 5 -0.0264046
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0264026
WASF2 WAS protein family, member 2 -0.026359
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0262602
CLTC clathrin, heavy chain (Hc) -0.0261615
PNISR PNN-interacting serine/arginine-rich protein -0.025794
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0257627
CANX calnexin -0.0254973
DSCAM Down syndrome cell adhesion molecule -0.0254166
ZMYM2 zinc finger, MYM-type 2 -0.0253682
RAB7A RAB7A, member RAS oncogene family -0.025123
NIPBL Nipped-B homolog (Drosophila) -0.0251101
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0251065
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0250638
CES1 carboxylesterase 1 -0.0249889
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0248257
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0247277
VCL vinculin -0.0246913
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0245651
SEPTIN10 septin 10 -0.024439
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0241954
STRN3 striatin, calmodulin binding protein 3 -0.0241881
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.0240287