Resveratrol_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Resveratrol perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Resveratrol_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.134836
AKAP12 A kinase (PRKA) anchor protein 12 0.0781122
IGFBP3 insulin-like growth factor binding protein 3 0.0780071
SAMD4A sterile alpha motif domain containing 4A 0.0652632
KTN1 kinectin 1 (kinesin receptor) 0.0565923
FNDC3B fibronectin type III domain containing 3B 0.0563025
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0549034
ATXN1 ataxin 1 0.0532406
MCL1 myeloid cell leukemia 1 0.0525969
SOD2 superoxide dismutase 2, mitochondrial 0.0524126
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0521463
UBASH3B ubiquitin associated and SH3 domain containing B 0.0518553
ZSWIM6 zinc finger, SWIM-type containing 6 0.0508945
KIAA0319 KIAA0319 0.0455905
DOCK4 dedicator of cytokinesis 4 0.0444369
MYOF myoferlin 0.0433869
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0431352
RICTOR RPTOR independent companion of MTOR, complex 2 0.0427284
EGFR epidermal growth factor receptor 0.0394099
SPIRE1 spire-type actin nucleation factor 1 0.0392714
PCBP2 poly(rC) binding protein 2 0.0386943
BMP6 bone morphogenetic protein 6 0.0383817
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0383231
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0357199
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0346221
MACF1 microtubule-actin crosslinking factor 1 0.0345002
FAM107B family with sequence similarity 107, member B 0.0340926
ELL2 elongation factor, RNA polymerase II, 2 0.0338831
NCEH1 neutral cholesterol ester hydrolase 1 0.0330864
SMAD3 SMAD family member 3 0.0323586
FMNL2 formin-like 2 0.0323569
WAC WW domain containing adaptor with coiled-coil 0.0321977
APLP2 amyloid beta (A4) precursor-like protein 2 0.0320395
RB1CC1 RB1-inducible coiled-coil 1 0.0310097
RUNX1 runt-related transcription factor 1 0.0308911
GLS2 glutaminase 2 (liver, mitochondrial) 0.0305613
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0304786
CYTH1 cytohesin 1 0.0302939
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0299264
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0293974
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0290883
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0290861
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0289659
MYH9 myosin, heavy chain 9, non-muscle 0.028877
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0288287
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0285055
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0285031
BTBD9 BTB (POZ) domain containing 9 0.0282175
LPP LIM domain containing preferred translocation partner in lipoma 0.0279099
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0277767
PDE4D phosphodiesterase 4D, cAMP-specific 0.0273186
TPM3 tropomyosin 3 0.0272401
AGO2 argonaute RISC catalytic component 2 0.0264366
MED13 mediator complex subunit 13 0.0258391
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0258254
DIAPH1 diaphanous-related formin 1 0.0256256
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0255933
TRIO trio Rho guanine nucleotide exchange factor 0.0253711
RPL3 ribosomal protein L3 0.0251761
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0251674
ARHGAP26 Rho GTPase activating protein 26 0.0250781
MYO1E myosin IE 0.0243981
PTPRM protein tyrosine phosphatase, receptor type, M 0.0241879
BIRC6 baculoviral IAP repeat containing 6 0.0241723
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.024162
NUMB numb homolog (Drosophila) 0.0240601
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0239891
KIF13A kinesin family member 13A 0.0238015
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0236204
SNX14 sorting nexin 14 0.0235707
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0235673
FOXO3 forkhead box O3 0.0234835
SMOC1 SPARC related modular calcium binding 1 0.0233964
BIRC3 baculoviral IAP repeat containing 3 0.0233959
PFKP phosphofructokinase, platelet 0.0232239
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0229931
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0229446
CHD1 chromodomain helicase DNA binding protein 1 0.0229173
SCAF8 SR-related CTD-associated factor 8 0.0229088
PHIP pleckstrin homology domain interacting protein 0.0227897
ITGAV integrin, alpha V 0.0227194
COPA coatomer protein complex, subunit alpha 0.0226777
BRWD1 bromodomain and WD repeat domain containing 1 0.022638
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0225081
FBXL20 F-box and leucine-rich repeat protein 20 0.022277
ITGB5 integrin, beta 5 0.0222436
SLMAP sarcolemma associated protein 0.0220505
GRB10 growth factor receptor-bound protein 10 0.0220441
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0219435
GOLGA4 golgin A4 0.0219278
ANKRD12 ankyrin repeat domain 12 0.0217291
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0216996
SNX9 sorting nexin 9 0.0215162
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0214154
AKAP13 A kinase (PRKA) anchor protein 13 0.0212611
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0211456
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0211
NCOA2 nuclear receptor coactivator 2 0.0210925
HSPA8 heat shock 70kDa protein 8 0.0209782
EPAS1 endothelial PAS domain protein 1 0.0209748

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.160024
TXNRD1 thioredoxin reductase 1 -0.136917
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.12237
PM20D1 peptidase M20 domain containing 1 -0.122101
FTL ferritin, light polypeptide -0.120119
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.113058
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.104027
HDAC9 histone deacetylase 9 -0.0850004
TFPI2 tissue factor pathway inhibitor 2 -0.0778782
PTMA prothymosin, alpha -0.0725484
SLC38A2 solute carrier family 38, member 2 -0.0680197
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0655985
IGF2 insulin-like growth factor 2 -0.0626874
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0615537
GRAMD1B GRAM domain containing 1B -0.0592895
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.053989
RAD21 RAD21 homolog (S. pombe) -0.0488209
BICC1 BicC family RNA binding protein 1 -0.0471424
WDR43 WD repeat domain 43 -0.0450537
FGB fibrinogen beta chain -0.0438
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0429671
ASPH aspartate beta-hydroxylase -0.0429611
CAVIN1 caveolae associated protein 1 -0.042359
ECT2 epithelial cell transforming 2 -0.0422916
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0406984
MYL12B myosin, light chain 12B, regulatory -0.0406774
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0394053
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0391002
S100A6 S100 calcium binding protein A6 -0.038324
BASP1 brain abundant, membrane attached signal protein 1 -0.0379036
YBX3 Y box binding protein 3 -0.0375367
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0374388
RPS21 ribosomal protein S21 -0.0358501
RSL1D1 ribosomal L1 domain containing 1 -0.0357166
RPL19 ribosomal protein L19 -0.0341949
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0340677
AHR aryl hydrocarbon receptor -0.0338959
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0338778
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0337238
MBNL1 muscleblind-like splicing regulator 1 -0.0336109
THBS1 thrombospondin 1 -0.0333925
ACACA acetyl-CoA carboxylase alpha -0.0332363
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0319258
RPL35A ribosomal protein L35a -0.0318725
SERF2 small EDRK-rich factor 2 -0.0318227
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0315174
TM4SF1 transmembrane 4 L six family member 1 -0.0313388
LDHA lactate dehydrogenase A -0.0306845
THSD4 thrombospondin, type I, domain containing 4 -0.0302985
PAWR PRKC, apoptosis, WT1, regulator -0.0301111
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0299154
EIF5B eukaryotic translation initiation factor 5B -0.028951
STC1 stanniocalcin 1 -0.0289105
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0288552
KYNU kynureninase -0.0288172
LAPTM4A lysosomal protein transmembrane 4 alpha -0.0283995
NRG1 neuregulin 1 -0.0282839
TPI1 triosephosphate isomerase 1 -0.0281518
VDAC1 voltage-dependent anion channel 1 -0.0278416
ENO1 enolase 1, (alpha) -0.0277783
ATP5F1B ATP synthase F1 subunit beta -0.0276448
RHEB Ras homolog enriched in brain -0.0276433
NEGR1 neuronal growth regulator 1 -0.0272657
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0272619
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0272336
TPM4 tropomyosin 4 -0.0272233
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0271882
BHLHE40 basic helix-loop-helix family, member e40 -0.0270119
BIRC2 baculoviral IAP repeat containing 2 -0.0269464
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.026695
CYRIB CYFIP related Rac1 interactor B -0.0266931
GARS1 glycyl-tRNA synthetase 1 -0.026053
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0260235
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0258438
RPS24 ribosomal protein S24 -0.0256904
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0255977
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0255675
TPT1 tumor protein, translationally-controlled 1 -0.0255063
RPL23 ribosomal protein L23 -0.0254243
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0253672
FGG fibrinogen gamma chain -0.0253252
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0242601
TUBB tubulin, beta class I -0.0240002
IGFBP4 insulin-like growth factor binding protein 4 -0.0238879
COL4A5 collagen, type IV, alpha 5 -0.0237777
PFDN2 prefoldin subunit 2 -0.0237471
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.0236822
ANKRD28 ankyrin repeat domain 28 -0.023516
HMGA1 high mobility group AT-hook 1 -0.0234397
KLF6 Kruppel-like factor 6 -0.0233346
ZNF804A zinc finger protein 804A -0.0232446
EFNA5 ephrin-A5 -0.0231642
LMNA lamin A/C -0.0231038
ILF2 interleukin enhancer binding factor 2 -0.0230701
RHOA ras homolog family member A -0.0230199
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0227351
AK1 adenylate kinase 1 -0.02262
ANLN anillin, actin binding protein -0.0225909
CHD9 chromodomain helicase DNA binding protein 9 -0.0225102
BABAM2 BRISC and BRCA1 A complex member 2 -0.0224941