Resveratrol_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Resveratrol perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Resveratrol_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.131859
BACE2 beta-site APP-cleaving enzyme 2 0.101765
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0951895
KYNU kynureninase 0.0907536
AKAP13 A kinase (PRKA) anchor protein 13 0.0850352
RAD51B RAD51 paralog B 0.0814957
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0784445
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0763183
MACC1 metastasis associated in colon cancer 1 0.072459
HSPH1 heat shock 105kDa/110kDa protein 1 0.0720055
ARHGAP21 Rho GTPase activating protein 21 0.0712571
SLTM SAFB-like, transcription modulator 0.0671426
TXNRD1 thioredoxin reductase 1 0.0650611
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0643406
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0642257
MYO5B myosin VB 0.0594435
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0594305
SMOC1 SPARC related modular calcium binding 1 0.0585546
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0562798
DSCAM Down syndrome cell adhesion molecule 0.0543925
TOP1 topoisomerase (DNA) I 0.0533718
AFF1 AF4/FMR2 family, member 1 0.0529795
KRT17 keratin 17, type I 0.05263
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0521981
IGF1R insulin-like growth factor 1 receptor 0.0511136
POTEF POTE ankyrin domain family, member F 0.0503426
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0492427
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0485462
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0479965
TTC3 tetratricopeptide repeat domain 3 0.0479757
RAB7A RAB7A, member RAS oncogene family 0.0470437
PTEN phosphatase and tensin homolog 0.0468322
RPL31 ribosomal protein L31 0.0466811
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0466468
EZR ezrin 0.0466043
GSK3B glycogen synthase kinase 3 beta 0.0461982
MYOF myoferlin 0.045955
NCOA3 nuclear receptor coactivator 3 0.0457522
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0455291
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0454025
RPL23 ribosomal protein L23 0.0452083
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0444523
CLIC4 chloride intracellular channel 4 0.0441587
ATP11A ATPase, class VI, type 11A 0.0437309
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.043322
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0432519
BMAL2 basic helix-loop-helix ARNT like 2 0.0430031
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0429065
DUSP10 dual specificity phosphatase 10 0.0422582
SLK STE20-like kinase 0.0421704
PARD6B par-6 family cell polarity regulator beta 0.0420741
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0418525
NBAS neuroblastoma amplified sequence 0.0414329
SVIL supervillin 0.0406364
QKI QKI, KH domain containing, RNA binding 0.0403059
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 0.0400116
PDE10A phosphodiesterase 10A 0.0392722
NPEPPS aminopeptidase puromycin sensitive 0.0392594
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 0.0389512
DPYD dihydropyrimidine dehydrogenase 0.0389258
ANKRD17 ankyrin repeat domain 17 0.0388859
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0385715
OSBPL3 oxysterol binding protein-like 3 0.0382954
SRPK2 SRSF protein kinase 2 0.0381164
IFIH1 interferon induced with helicase C domain 1 0.0379583
RLF rearranged L-myc fusion 0.0379161
EGFR epidermal growth factor receptor 0.0372004
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0371179
SCAF11 SR-related CTD-associated factor 11 0.0370392
SMC5 structural maintenance of chromosomes 5 0.0369947
ZC3H3 zinc finger CCCH-type containing 3 0.0366432
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0364421
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0361539
THSD4 thrombospondin, type I, domain containing 4 0.0358122
ENO1 enolase 1, (alpha) 0.0351654
ANXA11 annexin A11 0.0351129
RPL26 ribosomal protein L26 0.0348303
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0337315
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.033521
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0333787
FOXO3 forkhead box O3 0.0332671
PRDM1 PR domain containing 1, with ZNF domain 0.0332199
ZMYM5 zinc finger, MYM-type 5 0.0331128
CSNK1A1 casein kinase 1, alpha 1 0.0330586
NACA nascent polypeptide-associated complex alpha subunit 0.0329997
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0327452
EPS8 epidermal growth factor receptor pathway substrate 8 0.0325007
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0324859
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0324779
SQSTM1 sequestosome 1 0.032469
GPHN gephyrin 0.0324052
SOS1 son of sevenless homolog 1 (Drosophila) 0.0323582
B2M beta-2-microglobulin 0.0322751
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0322626
CNOT4 CCR4-NOT transcription complex, subunit 4 0.031889
SLMAP sarcolemma associated protein 0.0316261
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0315742
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0315298
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0312819
KMT2C lysine (K)-specific methyltransferase 2C 0.0312736

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.164504
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.158082
PDE4D phosphodiesterase 4D, cAMP-specific -0.131304
CEMIP cell migration inducing protein, hyaluronan binding -0.129471
GRB10 growth factor receptor-bound protein 10 -0.119093
SAMD4A sterile alpha motif domain containing 4A -0.1047
SHB Src homology 2 domain containing adaptor protein B -0.099277
FNDC3B fibronectin type III domain containing 3B -0.0987889
COL6A3 collagen, type VI, alpha 3 -0.0979579
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0944071
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.094212
MMP1 matrix metallopeptidase 1 -0.093447
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0867183
IGFBP3 insulin-like growth factor binding protein 3 -0.0859008
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0825788
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0822198
NALF1 NALCN channel auxiliary factor 1 -0.0789713
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0788482
AHNAK AHNAK nucleoprotein -0.0769351
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0737847
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0728406
FAM13A family with sequence similarity 13, member A -0.0706842
HOMER1 homer scaffolding protein 1 -0.0678731
LAMB3 laminin, beta 3 -0.0678721
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0676692
ZSWIM6 zinc finger, SWIM-type containing 6 -0.067384
LAMC2 laminin, gamma 2 -0.0669098
ADGRB3 adhesion G protein-coupled receptor B3 -0.0647959
NAMPT nicotinamide phosphoribosyltransferase -0.0637099
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.063141
RORA RAR-related orphan receptor A -0.0619683
MAML3 mastermind-like 3 (Drosophila) -0.06183
SEPTIN10 septin 10 -0.0611508
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0600065
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0590095
ABI3BP ABI family, member 3 (NESH) binding protein -0.0582214
LDHA lactate dehydrogenase A -0.0574269
DOCK5 dedicator of cytokinesis 5 -0.0567368
TRPS1 trichorhinophalangeal syndrome I -0.0561523
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0549844
VMP1 vacuole membrane protein 1 -0.0548471
SOD2 superoxide dismutase 2, mitochondrial -0.0528822
ANTXR2 anthrax toxin receptor 2 -0.0521651
PLAUR plasminogen activator, urokinase receptor -0.0520319
RBM47 RNA binding motif protein 47 -0.0518057
ARHGAP32 Rho GTPase activating protein 32 -0.0517443
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0514272
SACK1A scaffolding CK1 anchoring protein A -0.0511567
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0498514
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0498341
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0494122
MXD1 MAX dimerization protein 1 -0.0490011
ATP13A3 ATPase type 13A3 -0.0475999
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.047574
FTH1 ferritin, heavy polypeptide 1 -0.0471674
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.047146
NDRG1 N-myc downstream regulated 1 -0.0467471
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0464001
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0461233
WARS1 tryptophanyl-tRNA synthetase 1 -0.0441289
HPCAL1 hippocalcin-like 1 -0.0438105
AGFG1 ArfGAP with FG repeats 1 -0.0432534
FLNB filamin B, beta -0.0430425
ZMYND8 zinc finger, MYND-type containing 8 -0.0430047
TC2N tandem C2 domains, nuclear -0.0416443
S100A9 S100 calcium binding protein A9 -0.0415147
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0409125
PARD3 par-3 family cell polarity regulator -0.0408498
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0406566
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0405528
ANKRD11 ankyrin repeat domain 11 -0.0395139
HLA-B major histocompatibility complex, class I, B -0.0393605
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0393513
OXR1 oxidation resistance 1 -0.0392724
AKAP12 A kinase (PRKA) anchor protein 12 -0.0391994
C1D C1D nuclear receptor corepressor -0.038458
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0384232
CDH13 cadherin 13 -0.0382029
DENND4A DENN/MADD domain containing 4A -0.0378724
TMSB10 thymosin beta 10 -0.0378592
MAML2 mastermind-like 2 (Drosophila) -0.0378194
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.037622
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0372378
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0363186
ATF6 activating transcription factor 6 -0.0361496
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0356221
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0353923
CA12 carbonic anhydrase XII -0.035067
DOCK1 dedicator of cytokinesis 1 -0.0347497
SCFD1 sec1 family domain containing 1 -0.0345225
HIPK2 homeodomain interacting protein kinase 2 -0.0341809
ARHGAP12 Rho GTPase activating protein 12 -0.0341605
FRMD5 FERM domain containing 5 -0.0335138
DIAPH2 diaphanous-related formin 2 -0.0333364
EMP1 epithelial membrane protein 1 -0.033214
AK1 adenylate kinase 1 -0.0331503
LPP LIM domain containing preferred translocation partner in lipoma -0.0330552
RTN4 reticulon 4 -0.0328414
ACTG1 actin gamma 1 -0.032613
GRAMD1B GRAM domain containing 1B -0.0321373