Resveratrol_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Resveratrol perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Resveratrol_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.222532
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.108706
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0978049
ERRFI1 ERBB receptor feedback inhibitor 1 0.0845522
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0787713
TPM3 tropomyosin 3 0.0625051
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0573838
ZCCHC7 zinc finger, CCHC domain containing 7 0.055101
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.054962
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.054936
MCL1 myeloid cell leukemia 1 0.053242
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0523147
ENO1 enolase 1, (alpha) 0.0511597
KTN1 kinectin 1 (kinesin receptor) 0.0478939
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0448694
PCBP2 poly(rC) binding protein 2 0.0427274
AFF3 AF4/FMR2 family, member 3 0.0416258
FMNL2 formin-like 2 0.0407817
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0406918
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0401948
ATXN1 ataxin 1 0.039213
EEF2 eukaryotic translation elongation factor 2 0.0381809
PRELID2 PRELI domain containing 2 0.0361727
PRKCE protein kinase C, epsilon 0.0341398
PDE4D phosphodiesterase 4D, cAMP-specific 0.033456
MACF1 microtubule-actin crosslinking factor 1 0.0330296
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0327352
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0309784
DSPP dentin sialophosphoprotein 0.0306057
CHD1L chromodomain helicase DNA binding protein 1-like 0.0304761
GOLGB1 golgin B1 0.0298513
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0293915
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0293025
WWOX WW domain containing oxidoreductase 0.0284236
RPL37 ribosomal protein L37 0.028068
MBD5 methyl-CpG binding domain protein 5 0.0271647
RABGAP1L RAB GTPase activating protein 1-like 0.0268082
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.02647
RSF1 remodeling and spacing factor 1 0.0261639
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0257823
DOCK5 dedicator of cytokinesis 5 0.02566
RAB6A RAB6A, member RAS oncogene family 0.0255814
PYGL phosphorylase, glycogen, liver 0.0254768
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.025415
CANX calnexin 0.0253252
PKM pyruvate kinase, muscle 0.0247429
FAM13A family with sequence similarity 13, member A 0.0245684
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0245438
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0244821
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0242302
EEF1G eukaryotic translation elongation factor 1 gamma 0.0239297
THSD4 thrombospondin, type I, domain containing 4 0.0237864
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0235567
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0233717
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0232094
KRT18 keratin 18, type I 0.0231974
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0229064
TRIM9 tripartite motif containing 9 0.0227504
PDIA3 protein disulfide isomerase family A, member 3 0.0226638
KDM4C lysine (K)-specific demethylase 4C 0.0224119
EPAS1 endothelial PAS domain protein 1 0.0220701
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0216602
PDIA6 protein disulfide isomerase family A, member 6 0.021626
DST dystonin 0.021625
PARD3 par-3 family cell polarity regulator 0.0214595
RPL3 ribosomal protein L3 0.0214427
YBX1 Y box binding protein 1 0.0211698
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0210948
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0201725
ERBIN erbb2 interacting protein 0.0201245
DOCK7 dedicator of cytokinesis 7 0.0200221
TLN1 talin 1 0.019966
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0198641
AKAP9 A kinase (PRKA) anchor protein 9 0.019606
COPA coatomer protein complex, subunit alpha 0.0193848
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0193537
KDM5B lysine (K)-specific demethylase 5B 0.0192871
SOS2 son of sevenless homolog 2 (Drosophila) 0.0191068
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0190188
EGFR epidermal growth factor receptor 0.0189673
RPL4 ribosomal protein L4 0.0188553
VMP1 vacuole membrane protein 1 0.0185684
DENND5B DENN/MADD domain containing 5B 0.0185258
ASPH aspartate beta-hydroxylase 0.0182797
FAM168A family with sequence similarity 168, member A 0.0182543
DIAPH2 diaphanous-related formin 2 0.0182475
PFKP phosphofructokinase, platelet 0.018066
TPM2 tropomyosin 2 (beta) 0.0178924
POTEF POTE ankyrin domain family, member F 0.0178192
TLK1 tousled-like kinase 1 0.0177217
FOSL2 FOS-like antigen 2 0.0176607
MXI1 MAX interactor 1, dimerization protein 0.0175763
NDRG1 N-myc downstream regulated 1 0.0175468
KRT8 keratin 8, type II 0.0174316
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0174192
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.0173881
ZNF148 zinc finger protein 148 0.0173606
UBE2H ubiquitin-conjugating enzyme E2H 0.0172857
HYOU1 hypoxia up-regulated 1 0.0171789
GIGYF2 GRB10 interacting GYF protein 2 0.0171181

decreased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 -0.215275
TMSB10 thymosin beta 10 -0.110238
TXNRD1 thioredoxin reductase 1 -0.0891719
EGR1 early growth response 1 -0.0747184
PTMA prothymosin, alpha -0.065627
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0656159
YBX3 Y box binding protein 3 -0.0592842
MKI67 marker of proliferation Ki-67 -0.0589982
NABP1 nucleic acid binding protein 1 -0.0548731
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0548608
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0546885
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.054367
ELL2 elongation factor, RNA polymerase II, 2 -0.0539436
SLC38A2 solute carrier family 38, member 2 -0.0534747
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0516032
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0505976
MYL12B myosin, light chain 12B, regulatory -0.0503999
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.050388
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0494842
VCL vinculin -0.0483414
RRM2 ribonucleotide reductase M2 -0.0481726
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0471224
OSMR oncostatin M receptor -0.0465016
KLF6 Kruppel-like factor 6 -0.0446873
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0439844
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0434944
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.04134
MT2A metallothionein 2A -0.0390131
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.038299
NIPBL Nipped-B homolog (Drosophila) -0.0368092
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0366361
KPNB1 karyopherin (importin) beta 1 -0.0363971
SMC4 structural maintenance of chromosomes 4 -0.0359073
ZNFX1 zinc finger, NFX1-type containing 1 -0.0358764
NAP1L1 nucleosome assembly protein 1-like 1 -0.0355709
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0350365
FUS FUS RNA binding protein -0.0341364
TPT1 tumor protein, translationally-controlled 1 -0.0334361
WSB1 WD repeat and SOCS box containing 1 -0.0331383
WNT2B wingless-type MMTV integration site family, member 2B -0.0331287
ATF6 activating transcription factor 6 -0.0330382
PRRC2C proline-rich coiled-coil 2C -0.0325514
MARCHF4 membrane associated ring-CH-type finger 4 -0.0320563
RAB7A RAB7A, member RAS oncogene family -0.0319129
RBM25 RNA binding motif protein 25 -0.0317523
DOCK3 dedicator of cytokinesis 3 -0.031669
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0313062
CDK17 cyclin-dependent kinase 17 -0.031008
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0307669
CALD1 caldesmon 1 -0.0306978
TRIP12 thyroid hormone receptor interactor 12 -0.0306571
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.030635
DIAPH3 diaphanous-related formin 3 -0.0304785
RPL12 ribosomal protein L12 -0.0304616
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0303237
STK4 serine/threonine kinase 4 -0.030249
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0301781
FBXO11 F-box protein 11 -0.0301557
TPX2 TPX2, microtubule-associated -0.0299971
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0299952
TPI1 triosephosphate isomerase 1 -0.0298525
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0298032
RPS21 ribosomal protein S21 -0.0296812
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0291207
ADGRG6 adhesion G protein-coupled receptor G6 -0.0290685
MARCHF6 membrane associated ring-CH-type finger 6 -0.0289904
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0289567
PLSCR1 phospholipid scramblase 1 -0.0279012
TM4SF1 transmembrane 4 L six family member 1 -0.0278027
RPL35A ribosomal protein L35a -0.0277492
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0274791
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0272414
CDK12 cyclin-dependent kinase 12 -0.0271328
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0270269
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0269399
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0265698
ACTG1 actin gamma 1 -0.0264561
CENPF centromere protein F, 350/400kDa -0.0263889
MIS18BP1 MIS18 binding protein 1 -0.0262485
RIGI RNA sensor RIG-I -0.0259513
RPL19 ribosomal protein L19 -0.0259164
EXT1 exostosin glycosyltransferase 1 -0.0258195
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0258172
CLIP1 CAP-GLY domain containing linker protein 1 -0.0257617
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0255845
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0254906
SCLT1 sodium channel and clathrin linker 1 -0.0252742
TAS2R14 taste receptor, type 2, member 14 -0.0251105
PHIP pleckstrin homology domain interacting protein -0.0251087
RBBP6 retinoblastoma binding protein 6 -0.0249508
KIAA1328 KIAA1328 -0.0247348
ANLN anillin, actin binding protein -0.0247118
RAD21 RAD21 homolog (S. pombe) -0.0246054
TUBA1B tubulin, alpha 1b -0.0244665
EIF4A1 eukaryotic translation initiation factor 4A1 -0.024412
E2F3 E2F transcription factor 3 -0.024349
RHEB Ras homolog enriched in brain -0.0243133
RPL23 ribosomal protein L23 -0.0243097
VIM vimentin -0.0241854
SGO2 shugoshin 2 -0.0239813