Resveratrol_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Resveratrol perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Resveratrol_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.164002
TMSB4X thymosin beta 4, X-linked 0.0939251
TSC22D2 TSC22 domain family, member 2 0.0860552
SAMD4A sterile alpha motif domain containing 4A 0.0807047
FTH1 ferritin, heavy polypeptide 1 0.0791958
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0770594
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0714499
GRB10 growth factor receptor-bound protein 10 0.0708611
FTL ferritin, light polypeptide 0.0686395
LIMCH1 LIM and calponin homology domains 1 0.0607201
PCBP2 poly(rC) binding protein 2 0.0595789
EIF1 eukaryotic translation initiation factor 1 0.0591258
RPL4 ribosomal protein L4 0.0578528
KRT8 keratin 8, type II 0.0575466
ACTG1 actin gamma 1 0.0568563
CD109 CD109 molecule 0.0490286
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0485305
ACBD3 acyl-CoA binding domain containing 3 0.0443109
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0436653
FAM13A family with sequence similarity 13, member A 0.0429982
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0413362
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0413354
RPLP1 ribosomal protein, large, P1 0.040704
RPLP0 ribosomal protein, large, P0 0.0386983
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0383997
TMEM165 transmembrane protein 165 0.0383863
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0383513
KDM5B lysine (K)-specific demethylase 5B 0.0379126
EEF2 eukaryotic translation elongation factor 2 0.0356696
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0355668
BZW1 basic leucine zipper and W2 domains 1 0.0346974
KMT2C lysine (K)-specific methyltransferase 2C 0.0340877
RPL35A ribosomal protein L35a 0.0334022
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0332318
RPS12 ribosomal protein S12 0.0330873
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0329334
TPM4 tropomyosin 4 0.0317234
RPS8 ribosomal protein S8 0.0311652
STRN3 striatin, calmodulin binding protein 3 0.0302996
RPS20 ribosomal protein S20 0.0297656
YBX1 Y box binding protein 1 0.0294457
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.028053
EIF4B eukaryotic translation initiation factor 4B 0.0278407
EFNA5 ephrin-A5 0.0278246
RPL30 ribosomal protein L30 0.0275484
RB1CC1 RB1-inducible coiled-coil 1 0.0273787
CANX calnexin 0.0271879
ITCH itchy E3 ubiquitin protein ligase 0.0267411
DTNA dystrobrevin, alpha 0.0267286
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0266179
HLA-A major histocompatibility complex, class I, A 0.0259438
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0257514
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0257377
CERT1 ceramide transporter 1 0.0254142
RAB1A RAB1A, member RAS oncogene family 0.0253376
RPL37 ribosomal protein L37 0.0253176
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0252945
RPS27 ribosomal protein S27 0.0248574
KDM2A lysine (K)-specific demethylase 2A 0.0246421
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0246171
GNPDA1 glucosamine-6-phosphate deaminase 1 0.024571
SEC31A SEC31 homolog A (S. cerevisiae) 0.0245292
KLHL24 kelch-like family member 24 0.0245241
ZNF207 zinc finger protein 207 0.0243973
VEGFA vascular endothelial growth factor A 0.0243462
RLF rearranged L-myc fusion 0.024223
VIM vimentin 0.0241675
LDHA lactate dehydrogenase A 0.0238194
FBXO11 F-box protein 11 0.023514
RPL27A ribosomal protein L27a 0.0234641
SEC23A Sec23 homolog A (S. cerevisiae) 0.0233185
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.023063
FBXL20 F-box and leucine-rich repeat protein 20 0.022536
FNIP1 folliculin interacting protein 1 0.0225226
RAB6A RAB6A, member RAS oncogene family 0.0225213
NPEPPS aminopeptidase puromycin sensitive 0.022489
MCTP2 multiple C2 domains, transmembrane 2 0.022148
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0220199
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0218622
SRP54 signal recognition particle 54kDa 0.0216849
RACK1 receptor for activated C kinase 1 0.0214248
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0212381
ESYT2 extended synaptotagmin-like protein 2 0.0211372
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0209845
BLZF1 basic leucine zipper nuclear factor 1 0.0206436
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.0204151
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0203717
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0202723
ARF1 ADP-ribosylation factor 1 0.0202699
HBP1 HMG-box transcription factor 1 0.0201459
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0200618
EIF4A2 eukaryotic translation initiation factor 4A2 0.0199333
RIOK3 RIO kinase 3 0.0198784
ARL8B ADP-ribosylation factor-like 8B 0.0198654
ATG14 autophagy related 14 0.0198487
MKRN1 makorin ring finger protein 1 0.0198465
RNASE3 ribonuclease, RNase A family, 3 0.0197886
EEF1G eukaryotic translation elongation factor 1 gamma 0.0197267
RAI14 retinoic acid induced 14 0.0194268
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0194205

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.186195
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.136748
NDRG1 N-myc downstream regulated 1 -0.131834
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.122981
ASPH aspartate beta-hydroxylase -0.119375
ALCAM activated leukocyte cell adhesion molecule -0.114435
PTMA prothymosin, alpha -0.0985465
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.098318
FN1 fibronectin 1 -0.0912805
LAMC2 laminin, gamma 2 -0.0841657
NAMPT nicotinamide phosphoribosyltransferase -0.0828556
ZFP36L1 ZFP36 ring finger protein-like 1 -0.076782
HMGA1 high mobility group AT-hook 1 -0.0756531
TMSB10 thymosin beta 10 -0.0746936
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0721524
MT2A metallothionein 2A -0.0666084
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0657994
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0591812
TM4SF1 transmembrane 4 L six family member 1 -0.0571383
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0555412
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0555133
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0535297
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0509482
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.049124
DSG2 desmoglein 2 -0.0486266
MKI67 marker of proliferation Ki-67 -0.0468807
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0459885
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0442438
FNDC3B fibronectin type III domain containing 3B -0.0430817
LAMB3 laminin, beta 3 -0.0423526
EXT1 exostosin glycosyltransferase 1 -0.0412029
IFI27 interferon, alpha-inducible protein 27 -0.0411047
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0395948
FHIT fragile histidine triad -0.0391592
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0376887
ADAR adenosine deaminase, RNA-specific -0.0370907
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0368435
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0361946
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0360103
ARHGAP5 Rho GTPase activating protein 5 -0.0359573
AREG amphiregulin -0.0356402
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0355759
MBNL1 muscleblind-like splicing regulator 1 -0.0354704
LY6E lymphocyte antigen 6 complex, locus E -0.0345661
G0S2 G0/G1 switch 2 -0.0343977
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0337355
RNF213 ring finger protein 213 -0.0332179
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0329913
AHNAK AHNAK nucleoprotein -0.0327746
PRRC2C proline-rich coiled-coil 2C -0.0320626
KLF6 Kruppel-like factor 6 -0.0317815
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0313714
IFI6 interferon, alpha-inducible protein 6 -0.0309271
SP100 SP100 nuclear antigen -0.0306186
GOLGA4 golgin A4 -0.0301091
ELL2 elongation factor, RNA polymerase II, 2 -0.030094
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0297916
CENPF centromere protein F, 350/400kDa -0.0295565
TACSTD2 tumor-associated calcium signal transducer 2 -0.0295399
CD46 CD46 molecule, complement regulatory protein -0.0293454
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0289767
WSB1 WD repeat and SOCS box containing 1 -0.028683
IFI44L interferon-induced protein 44-like -0.0286172
RPL32 ribosomal protein L32 -0.0285248
KRT7 keratin 7, type II -0.0283794
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.028279
SMC4 structural maintenance of chromosomes 4 -0.0277463
ANLN anillin, actin binding protein -0.0274918
HMGB2 high mobility group box 2 -0.0274106
IFI16 interferon, gamma-inducible protein 16 -0.0273677
SETD5 SET domain containing 5 -0.0273436
CD2AP CD2-associated protein -0.0267151
NRIP1 nuclear receptor interacting protein 1 -0.0264319
TNIP1 TNFAIP3 interacting protein 1 -0.0263235
RASA2 RAS p21 protein activator 2 -0.0260662
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0256188
TXNRD1 thioredoxin reductase 1 -0.0255971
PLSCR1 phospholipid scramblase 1 -0.0255888
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0254026
GRAMD2B GRAM domain containing 2B -0.0252451
PLEC plectin -0.0250579
H1-0 H1.0 linker histone -0.0249986
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0249339
RPS2 ribosomal protein S2 -0.0243409
DSPP dentin sialophosphoprotein -0.0243388
SGMS2 sphingomyelin synthase 2 -0.024324
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0242518
ECT2 epithelial cell transforming 2 -0.0241673
NKTR natural killer cell triggering receptor -0.0240262
DST dystonin -0.0239444
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0239189
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0238846
ARHGAP29 Rho GTPase activating protein 29 -0.0236085
MAP4 microtubule-associated protein 4 -0.0234953
KIAA1217 KIAA1217 -0.0234487
CTTN cortactin -0.0234231
AFDN afadin, adherens junction formation factor -0.0233804
IFIH1 interferon induced with helicase C domain 1 -0.023266
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0232627
TJP1 tight junction protein 1 -0.0232461